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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Supermemory descent methods for unconstrained minimization显示文摘 | Wolfe M A Viazminsky C | 1976 | J Optim Theory and Appl1976，18，4： | 2 |
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| 4 | Dynamic susceptibility contrast perfusion MRI identifies persistent vessel pathology in acute pontine stroke 显示文摘 | Forster A Ottomeyer C Wolf ME | 2010 | Cerebrovasc Dis2010，29，4： | 1 |
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| 8 | Relationships within and among species of the holoparasitic genus Hyobanche (Orobanchaceae) inferred from ISSR banding patterns and nucleotide sequences 显示文摘 | Wolfe A D Randle C P | 2001 | Syst Bot2001，26，： | 1 |
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| 10 | Current estimates of the economic cost of obesity in the United States 显示文摘 | WOLF A M C OLDITZ G A | 1998 | Obesity Research1998，6，2： | 1 |
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| 14 | Artificial insemination in deer and non-domestic bovids 显示文摘 | Morrow C J Penfold L M Wolfe B A | 2009 | Theriogenology2009，71，1： | 1 |
| 15 | Determinants of care costs of patients with dementia or cognitive impairment显示文摘 | Handels R L Wolfs C A Aalten P | 2013 | Alzheimer Dis Assoc Disord2013，27，1： | 1 |
| 16 | Skin island flaps supplied by the vascular axis of the sensitive superficial nerves:anatomic study and clinical experience in the leg显示文摘 | Romana M C Wolf G | 1992 | Plast Reconstr Surg1992，89，6： | 1 |
| 17 | Detection of roads and linear structures in low-resolution aerial imagery using a multi-source knowledge integration tecknique显示文摘 | FISCHLER M A TENENBAUM J M WOLF H C | 1983 | Computer Graphics and Image Processing1983，15，： | 1 |
| 18 | Cardio- vascular mortality in children and young adults with end-stage kidney disease显示文摘 | PAREKH R S CARROLL C E WOLFE R A | 2002 | The Journal of Pediatrics2002，141，2： | 1 |
| 19 | Disintegration of the Scrophulariaceae 显示文摘 | OLMSTEAD R G DEPAMPHILIS C W WOLFE A D | 2001 | American Journal of Botany2001，88，2： | 1 |
| 20 | Bom to run:competition enhances the spread of genes from crops to wild relatives 显示文摘 | Wolfe L M Blair A C | 2007 | New Phytolo- gist2007，173，3： | 1 |
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