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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Laparoscopic and open anterior resection for upper and mid rectal cancer:an evaluation of outcomes显示文摘 | Law WL Lee YM Choi HK | 2006 | Dis Colon Rectum2006，49，8： | 1 |
| 3 | Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications 显示文摘 | Roberts WL Moulton L Law TC | 2001 | Part 2 Clinical Chemistry2001，47，： | 1 |
| 4 | Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision显示文摘 | Law WL Chu KW Ho JW | 2000 | Am J Surg2000，179，2： | 1 |
| 5 | Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival 显示文摘 | Law WL Lee YM Cboi HK | 2007 | Ann Surg2007，245，1： | 1 |
| 6 | Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer:a case-matched study显示文摘 | Ng KC Law WL Lee YM | 2006 | J Gastrointest Surg2006，10，6： | 1 |
| 7 | Emeryeney surgery for obstmc tion colorectal cancers: a comparison between right-sided and left-sided lesiou显示文摘 | Lee YM Law WL Chu KW | 2001 | AM coll surg2001，192，6： | 1 |
| 8 | Self-expanding metallic stent in the treatment of colonic obstruction caused by advanced malignancies显示文摘 | Law WL Chu KW Ho JW | 2000 | Dis Colon Rectum2000，43，11： | 1 |
| 9 | Bowelpreparation for colonoscopy:a randomized controlled trial comparing polyethylene glycol solution,one dose and two doses of oral sodium phosphate solution显示文摘 | Law WL Choi HK Chu KW | 2004 | Asian J Surg2004，27，2： | 1 |
| 10 | Therapeutic value of gastrografin in adhesive small bowel obstruction after unsuccessful concervative treatment: a prospective randomized trial显示文摘 | Choi HK Chu KW Law WL | 2002 | Ann Surg2002，236，： | 1 |
| 11 | Evaluation of nine auto- mated high sensitivity C-reactive protein methods implications for clinical and epidemiological applications显示文摘 | Roberts Wl Moulton L Law TC | 2001 | Clin Chem2001，47，3： | 1 |
| 12 | Laparoscopic colectomy for obstructing sigmoid cancer with prior insertion of an expandable metallic stent显示文摘 | Law WL Choi HK Lee YM | 2004 | Surg Laparosc Endosc Percutan Tech2004，14，1： | 1 |
| 13 | Craniopharyngioma显示文摘 | Laws ER Weiss MH White WL | 2003 | Skull Base2003，13，1： | 1 |
| 14 | Emergency surgery for obstructing colorectal cancer:a comparison between right-sided and left-sided lesions显示文摘 | Lee YM Law WL Chu KW | 2001 | J Am Coll Surg2001，192，6： | 1 |
| 15 | Enhanced localization of osteoid osteoma with radiolabeling and intraoperative gamma counter guidance:a case report显示文摘 | Tse WL Hung LK Law B | 2003 | J Hand Surg(Am)2003，28，4： | 1 |
| 16 | Triple rubber band ligation for hen,- orrhoids: prospective, randomized trial of use of local anesthetic injection显示文摘 | Law WL Chu KW | 1999 | Dis Colon Rectum1999，42，3： | 1 |
| 17 | Prognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal cancer显示文摘 | Chok KS Law WL | 2007 | World J Surg2007，31，7： | 1 |
| 18 | Evluation of nine animated high sensitivity C-reactive protein methods:im-plications for clinical and epidemiological applications 显示文摘 | Rberts WL Mouton L Law TC | 2001 | Clin Chem2001，47，： | 1 |
| 19 | Emorgency resection and primary anastomosis for left-sided obstructing colorectal carcinoma in the e|derly显示文摘 | Poon RT Law WL Chu KW | 1998 | Br J Surg1998，85，： | 1 |
| 20 | Impact of total mesorectal excision on the results of surgery of distal rectal cancer显示文摘 | Chu KW | 2001 | Br J Sury2001，88，12： | 1 |
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