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| 1 | Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years. | Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya | 2014 | World Journal of Gastroenterology2014，20，5： | 21 |
| 2 | Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction:A review of clinical evidence and guidelines显示文摘Acute ST segment elevation myocardial infarction(STEMI) is characterized by complete thrombotic occlusion of a major coronary artery. Early recanalization of the infarct-related artery is most efficiently delivered by primary percutaneous coronary intervention(PPCI),however this does not always restore normal myocardial perfusion,mainly due to distal embolization of the thrombus and microvascular obstruction. Early evidence for manual thrombus aspiration during PPCI was promising and this was once considered an important aspect of the procedure,especially in patients with a high thrombus burden. However,a large body of evidence from recent major randomized controlled trials(notably TASTE and TOTAL) does not support the routine use of manual thrombus aspiration in patients with STEMI undergoing PPCI. | Muhammad Muzaffar Mahmood Jonathan Watt Javed M Ahmed | 2015 | World Journal of Cardiology2015，7，12： | 7 |
| 3 | 原发性低密度脂蛋白胆固醇≥4.94mmol/L的男性降低低密度脂蛋白胆固醇对心血管病的影响显示文摘原发性低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)≥4.94mmol/L(190mg/dL)的患者由于长期暴露在显著升高的LDL-C下,心血管动脉粥样硬化的风险更高。因此,对于这些患者通常建议采用他汀类药物治疗,但是缺少随机试验证据支持。在该研究中,研究者提供了一些降低LDL-C对心血管病影响的初级预防资料。 | Vallejo-Vaz AJ Robertson M Catapano AL Watts GF Kastelein JJ Packard CJ Ford I Ray KK 黄洁 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 5 |
| 4 | Anaerobic Ammonia - oxidizing Bacteria and Related Activity in Baltimore Inner Harbor Sedi2ment 显示文摘 | Tal Y Watts J E M Schreier H J | 2005 | Applied and Environmental Microbiology2005，71，4： | 1 |
| 5 | 显示文摘 | Kinloch A J Little M S G Watts J F | 2000 | Aeta Mater2000，48，： | 1 |
| 6 | Characterisation of airbome particles in London by computer-controlled scanning electron microscopy 显示文摘 | Sitzmann B Kendall M Watt J | 1999 | Science of the Total Environment1999，241，13： | 1 |
| 7 | Effect of additives and refrigeration on reducing activity, metmyoglobiin and malonaldehyde of raw ground beef显示文摘 | Hutchins B K Liu T H P Watts B M | 1967 | J Food Sci1967，32，： | 1 |
| 8 | Toxicity of ammonia and nitrite to juvenile Anstralian crayfish,Cherax quadricarinatus显示文摘 | MEADE M E WATTS S A | 1995 | Sheltfish Reseach1995，，14： | 1 |
| 9 | Identity and search in social networks显示文摘 | Watts D J Dodds P S Newman M E J | 2002 | Science2002，296，： | 1 |
| 10 | Effects of dynamic exer- cise intensity on the activation of hormone-sensitive lipase in human skeletal muscle 显示文摘 | Watt M J George JF Lawrence L | 2003 | J Physiol2003，547，1： | 1 |
| 11 | Renormalization group analysis of the small-world network model显示文摘 | Newman M E J Watts D J | 1999 | Physics Letters A1999，263，4： | 1 |
| 12 | Fundamental- mode basin oscillations in the Japan/East Sea显示文摘 | Xu Yongsheng Watts D R Wimbush M | 2007 | Geophysical Research Letters2007，34，4： | 1 |
| 13 | The use of reflectance spectrophotometery for the assay of raw meat pigments 显示文摘 | Stewart M R Zipser M W Watts B M | 1965 | Journal of Food Science1965，30，： | 1 |
| 14 | The Relation between Earnings and Cash Flows显示文摘 | DECHOW P M KOTHARI S P WATTS R L | 1998 | Journal of Accounting and Economics1998，25，2： | 1 |
| 15 | Clinical stem cell therapies for se- vere autoimmune diseases显示文摘 | Snowden J A Martin R E Watt S M | 2009 | Transfus Med2009，19，： | 1 |
| 16 | Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection显示文摘 | Bertram E M Lau P Watts T H | 2002 | J Immunol2002，168，8： | 1 |
| 17 | Chronic exposure to 17α-ethinylestradiol and bisphenol A-effects on development and reproduction in the freshwater invertebrate Chironomus riparius (Diptera: Chironomidae) 显示文摘 | Watts M M Rascoe D Carroll K | 2001 | Aquatic Toxicology2001，55，12： | 1 |
| 18 | Use of the freshwater macroinvertebrate Chironomus riparius in the assessment of sediment toxicity显示文摘 | Watts M M Pascoe D | 1996 | Water Science and Technology1996，34，7： | 1 |
| 19 | Effect of the plasma density scale length on the direction of fast electrons in relativistic laser-solid interactions显示文摘 | Santala M I K Zepf M Watts I | 2000 | Phys Rev Lett2000，84，： | 1 |
| 20 | Nasal delivery of Insuline using noval chitosan based formulations:A comparative study in two animal models between simple chitosan formulationand chitosan nanopartieles显示文摘 | DYER A M HINCHCLIFFE M WATTS P | 2002 | Pharm Res2002，19，7： | 1 |
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