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| 1 | Immunopathology of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)results from a complex series of interactions between susceptibility genes,the environment,and the immune system.The host microbiome,as well as viruses and fungi,play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.New technologies have allowed researchers to be able to quantify the various components of the microbiome,which will allow for future developments in the etiology of IBD.Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells,innate lymphoid cells,cells of the innate(macrophages/monocytes,neutrophils,and dendritic cells)and adaptive(T-cells and B-cells)immune system,and their secreted mediators(cytokines and chemokines).Either a mucosal susceptibility or defect in sampling of gut luminal antigen,possibly through the process of autophagy,leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity.The antigen presenting cells then mediate the differentiation of na?ve T-cells into effector T helper(Th)cells,including Th1,Th2,and Th17,which alter gut homeostasis and lead to IBD.In this review,the effects of these components in the immunopathogenesis of IBD will be discussed. | Kori L Wallace Li-Bo Zheng Yoshitake Kanazawa David Q Shih | 2014 | World Journal of Gastroenterology2014，20，1： | 45 |
| 2 | Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy显示文摘This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvements in the detection of NSAID-induced damage in the small intestine, it is now clear that this injury and the associated bleeding occurs more frequently than that occurring in the stomach and duodenum, and can also be regarded as more dangerous. However, there are no proven-effective therapies for NSAID-enteropathy, and detection remains a challenge, particularly because of the poor correlation between tissue injury and symptoms. Moreover, recent studies suggest that commonly used drugs for protecting the upper gastrointestinal tract (i.e., proton pump inhibitors) can significantly worsen NSAID-induced damage in the small intestine. The pathogenesis of NSAID-enteropathy is complex, but studies in animal models are shedding light on the key factors that contribute to ulceration and bleeding, and are providing clues to the development of effective therapies and prevention strategies. Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs. | John L Wallace | 2013 | World Journal of Gastroenterology2013，19，12： | 15 |
| 3 | Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa显示文摘 | Fiorucci S Santucci L Wallace JL | 2003 | PNAS2003，100，10： | 2 |
| 4 | Broadband magnetic microwave abso-rbers:fundamental limitations显示文摘 | Wallace J L | 1993 | IEEE Trans Magn1993，29，6： | 2 |
| 5 | Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review显示文摘AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword 'liver transplantation' was used in combination with the free term 'machine perfusion'. Clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically analysed.RESULTS Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be validated.CONCLUSION MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation. | Yuri L Boteon Amanda PCS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal Simon C Afford | 2018 | World Journal of Transplantation2018，8，6： | 2 |
| 6 | Endothelial nitric oxide synthase modulates gastric ulcer healing in rats显示文摘 | Wallace JL | 2000 | Am J Physiol Gastrointest Liver Physiol2000，279，： | 1 |
| 7 | Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascutarisation 显示文摘 | Nijjar SS Crosby HA Wallace L | 2001 | Hepatology2001，34，6： | 1 |
| 8 | The international at-sea intercomparison of f CO2 systems during the R/V Meteor cruise 36/1 in the North Atlantic Ocean 显示文摘 | Kortzinger A Mintrop L Wallace D W R | 2000 | Marine Chemistry2000，72，24： | 1 |
| 9 | New Generation NSAIDs: The Benefit Without the Risk显示文摘 | WALLACE J L CHIN B C | 1997 | Drugs Today1997，33，： | 1 |
| 10 | Role of angiography following aneurysm surgery显示文摘 | MACDONALD R L WALLACE M C KESTLE J R | 1993 | J Neurosurg1993，79，： | 1 |
| 11 | Endogenous andexogenous hydrogen, sulfide promotes resolution of colitisin rats 显示文摘 | Wallace JL Vong L McKnight W | 2009 | Gastroenterology2009，2009，2： | 1 |
| 12 | Tests of a precision tiltmeter system for measuring telescope posi- tion显示文摘 | KIBRICK R ROBINSON L WALLACE V | 1998 | SPIE1998，，： | 1 |
| 13 | The cellular and molecular basis of gastric mucosal defense显示文摘 | WALLACE J L GRANGER D N | 1996 | FASEB J1996，10，7： | 1 |
| 14 | Coadsorption of CO and 02 generation显示文摘 | Wallace W T Whetten R L | 2002 | J Am Chem Soc2002，124，25： | 1 |
| 15 | How software project risk affects project performance: An investigation of the di- mensions of risk and an exploratory model显示文摘 | Wallace L Keil M Rai A | 2004 | Decision Sciences2004，35，2： | 1 |
| 16 | Hydrogen sulfide-based therapeutics and gastrointestinal diseases : translating physiology to treatments显示文摘 | Chan M V Wallace J L | 2013 | Am J Physial Gastrointest Liver Physiol2013，305，7： | 1 |
| 17 | Understanding Software Project Risk:A Cluster Analysis显示文摘 | KEIL M RAI A | 2004 | Information and Management2004，42，1： | 1 |
| 18 | A randomized,controlled pilot study of a home-based exercise program for individuals with mild and moderate stroke显示文摘 | Duncan PW Richards L Wallace D | 1998 | Stroke1998，29，10： | 1 |
| 19 | Prolonged exposure of naive CD8+T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length 显示文摘 | Wallace D L B~rard M Soares M V | 2006 | Immunology2006，119，2： | 1 |
| 20 | Specific allergy immunotherapy for allergic rhini- tis:subcutaneous and sublingual 显示文摘 | Cox L Wallace D | 2011 | Immunol Allergy Clin North Am2011，31，3： | 1 |
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