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| 1 | Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study显示文摘It is well known that the safety and efficacy profile of an inhaled cortocosteroid(ICS) is influenced by the pharmacokinetic properties and associated pharmacodynamic effects of the drug. Freely circulating,protein unbound, and active ICS can cause systemic adverse effects. Therefore, a detailed investigation of drug-protein interaction could be of great interest to understand the pharmacokinetic behaviour of corticosteroids and for the design of new analogues with effective pharmacological properties. In the present work, the interaction between some corticosteroids and human serum albumin(HSA) has been studied by spectroscopic approaches. UV–Vis spectroscopy confirmed that all the investigated corticosteroids can bind to HSA forming a protein-drug complex. The intrinsic fluorescence of HSA was quenched by all the investigated drugs, which was rationalized in terms of a static quenching mechanism. The thermodynamic parameters determined by the Van't Hoff analysis of the binding constants(negative ΔH and ΔS values) clearly indicate thathydrogen bonds and van der Waals forces play a major role in the binding process between albumin and betamethasone, flunisolide and prednisolone, while hydrophobic forces may play a major role in stabilizing albumin-triamcinolone complexes. | Carlotta Pontremoli Nadia Barbero Guido Viscardi Sonja Visentin | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 2 |
| 2 | Zinc salt catalyzed rearrangement of acetals of optically active aryl 1-chloroethyl ketones:synthesis of optically active 2-arylpropionic acids and esters显示文摘 | Piccolo O Sfreafico F Visentin G | 1987 | J Org Chem1987，52，： | 1 |
| 3 | Selected materials issues associated with space station显示文摘 | Leger L Visentine J Santos-Mason B | 1987 | SAMPE Quarterly1987，18，2： | 1 |
| 4 | Validation of an antbsphingosine-l-phos- phate antibody as a potential therapeutic in reducing growth, invasion,and angiogenesis in multiple tumor lineages显示文摘 | Visentin B Vekich J A Sibbald B J Cavalli A L Moreno K M Matteo R G | 2006 | Canc- er Cell2006，9，： | 1 |
| 5 | Structural abnormalities and not diastolic dysfunction are the earliest left ventricular changes in hypertension显示文摘 | Palatini P Visentin P Mormino P | 1998 | Am J Hypertens1998，11，2： | 1 |
| 6 | Early primary cytomegalovirus infection in pregnancy:maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age显示文摘 | Visentin S Manara R Milanese L | 2012 | Clin Infect Dis2012，55，： | 1 |
| 7 | Treatment of 139 pregnancies in antiphospholipid-positive women not fulfilling criteria for antiphospholipid syndrome :a retrospective study显示文摘 | Del Ross T Ruffatti A Visentin MS | 2013 | J Rheumatol2013，40，4： | 1 |
| 8 | Pituitary adenomas in childhood and adolescence显示文摘 | De Menis E Visentin A Billeci D | 2001 | J Endocrinol Invest2001，24，2： | 1 |
| 9 | Inflammation and pruritus in haemodialysis patients显示文摘 | Virga G Visentin I La Milia V | 2002 | Nephrol Dial Transplant2002，17，12： | 1 |
| 10 | Pattern and determinants of hospitalization during heat waves: an ecologic study显示文摘 | Mastrangelo G Fedeli U Visentin C | 2007 | BMC Public Health2007，7，： | 1 |
| 11 | Selective intrauterine growth restriction in monochorionic twin pregnancies:markers of endothelial damage and metabolomic profile显示文摘 | COSMI E VISENTIN S FAVRETTO D | 2013 | Twin Research and Human Genetics:the Official Journal of the International Society for Twin Studies2013，16，4： | 1 |
| 12 | Hydrodynamic pressure sensing with an artificial lateral line in steady and unsteady flows显示文摘 | VENTURELLI R AKANYETI O VISENTIN F | 2012 | Bioinspir Biomim2012，7，03： | 1 |
| 13 | New 1,4-dihydropyridines conjugated to furoxanyl moiety,endowed with nitric oxide-like and calcium channel antagonist vasodilator activities显示文摘 | Stilo A D Visentin S Cena C | 1998 | J Med Chem1998，41，27： | 1 |
| 14 | Gallstone disease and related risk factors in patients with Crohn disease:analysis of 330 consecutive cases显示文摘 | Fraquelli M Losco A Visentin S | 2001 | Arch Intern Med2001，161，： | 1 |
| 15 | Drug interactions among the epidermal growth factor receptor inhibitors,other biologics and cytotoxic agents显示文摘 | Visentin M Biason P Toffoli G | 2010 | Pharmacol Ther2010，128，1： | 1 |
| 16 | Nitric oxide synthase in tissues around failed hip prosthese显示文摘 | Stea S Visentin M Donati ME | 2002 | Biomaterials2002，23，17： | 1 |
| 17 | Transabdominal sonography of the eavum septum pellueidum in normal fetuses in the second and third trimesters of pregnaney显示文摘 | Falco P Gabrielli S Visentin A | 2000 | Ultrasound Obstet Gyneeol2000，16，6： | 1 |
| 18 | Evidence-based policy on road safety : the effect of the demerit points system on seat belt use and health outcomes 显示文摘 | Zambon F Fedeli U Visentin C | 2007 | J Epidemiol Community Health2007，61，10： | 1 |
| 19 | Orbital life extension vehicle显示文摘 | CASWELL D VISENTIN G de KAM J | 2006 | ESA Bulletin2006，35，8： | 1 |
| 20 | Zinc salt catalyzed rearrangement of acetals of opticauy active aryl l-chloroethyl ketohes:Synthesis of Optically Active 2-Arylpropionic Acids显示文摘 | Piccolo O Spreafico F Visentin G | 1987 | J Ory Chem1987，5210，： | 1 |
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