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| 1 | Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment显示文摘Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options. | Tim CMA Schreuder Bart J Verwer Carin MJ van Nieuwkerk Chris JJ Mulder | 2008 | World Journal of Gastroenterology2008，14，16： | 35 |
| 2 | Positron emission tomography to assess hypoxia and perfusion in lung cancer显示文摘In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. | Eline E Verwer Ronald Boellaard Astrid AM van der Veldt | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 3 | Differential regulation and function of the Fas/Fas ligand system in human trophoblast cells显示文摘 | Straszewski S Verwer K M | 2002 | Biol Reprod2002，66，6： | 1 |
| 4 | Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one - generation reproduction study 显示文摘 | Lilienthal H Verwer C M Van der Ven T M | 2008 | Toxicology2008，246，1： | 1 |
| 5 | Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoim- mune hepatitis in remission显示文摘 | Van Gerven NM Verwer BJ Witte BI | 2013 | J Hepatol2013，58，1： | 1 |
| 6 | Discrimination ofAspergiUus len- tulus from Aspergillus fumigatus by Raman spectroscopy and MALDI-TOF MS 显示文摘 | Verwer P E van Leeuwen W B Girard V Monnin V van Belkum A Staab J F | 2014 | European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology2014，33，2： | 1 |
| 7 | Effect of carbonate pore structure on dynamic shear moduli显示文摘 | Verwer K Eberli G P Baechle G T | 2010 | Geophysics2010，75，1： | 1 |
| 8 | Effect of pore structure on electrical resistivity in carbonates显示文摘 | Verwer K Eberli G P Weger R J | 2011 | AAPG Bull2011，95，2： | 1 |
| 9 | Timing of surgical intervention in necrotizing pancreatitis显示文摘 | BessIink MG Verwer TJ Schoenmaeckers EJ | 2007 | Arch Surg2007，142，11： | 1 |
| 10 | Exposureto tetrabromobisphenol A(TBBPA)in Wistar rats:neurobehavioral effects inoffspring from a one-generation reproduction study显示文摘 | LILIENTHAL H VERWER C M VAN Der VEN L T | 2008 | Toxicology2008，246，1： | 1 |
| 11 | Cells in human postmortem brain tissue slices remain alive for several weeks in culture显示文摘 | Verwer R W Hermens W T Dijkhuizen P | 2002 | FASEB J2002，16，1： | 1 |
| 12 | Model study detecting breast cancer cells in peripheral blood mononuclear cells at frequencies as low as 10-7显示文摘 | Gross HJ Verwer B Houck D | 1995 | Proc Natl Acad Sci USA1995，92，2： | 1 |
| 13 | Boundary Value techniques for initial value problems in ordinary differential e-quations显示文摘 | Axelsson A O H and Verwer J G | 1985 | Math Comp1985，45，： | 1 |
| 14 | Timing of surgical intervention in necrotizing pancreatitis 显示文摘 | Besselink MG Verwer TJ Schoenmaeckers | 2007 | Arch Surg2007，142，12： | 1 |
| 15 | Risk assessment of posthepatectomy liver failure using hepatobiliary scintigraphy and CT volumetry 显示文摘 | Dinant S De GW Verwer B J | 2007 | J Nucl Med2007，48，5： | 1 |
| 16 | On the stability of implicit-explicit linear multistep methods显示文摘 | Frank J Hundsdorfer W and Verwer J G | 1997 | Applied Numerical Mathematics1997，25，23： | 1 |
| 17 | A numerical study of axon growth in the nervous system显示文摘 | Verwer JG Sommeijer BP | 2001 | Comput Appl Math2001，132，： | 1 |
| 18 | ROS3P-An accurate third-order Rosenbrock solver designed for parabolic problems 显示文摘 | Lang J Verwer J G | 2001 | BIT (S0006-3835)2001，41，4： | 1 |
| 19 | Timing of surgical intervention in necrotizing pancreatitis 显示文摘 | Besselink MG Verwer TJ Schoenmaeckers EJ | 2007 | Arch Surg2007，142，12： | 1 |
| 20 | Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remis- sion显示文摘 | van GERVEN NM VERWER B J WITTE BI | 2013 | J Hepatol2013，58，1： | 1 |
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