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| 1 | Skin bioprinting:the future of burn wound reconstruction?显示文摘Burns are a significant cause of trauma,and over the years,the focus of patient care has shifted from just survival to facilitation of improved functional outcomes.Typically,burn treatment,especially in the case of extensive burn injuries,involves surgical excision of injured skin and reconstruction of the burn injury with the aid of skin substitutes.Conventional skin substitutes do not contain all skin cell types and do not facilitate recapitulation of native skin physiology.Three-dimensional(3D)bioprinting for reconstruction of burn injuries involves layer-by-layer deposition of cells along with scaffolding materials over the injured areas.Skin bioprinting can be done either in situ or in vitro.Both these approaches are similar except for the site of printing and tissue maturation.There are technological and regulatory challenges that need to be overcome for clinical translation of bioprinted skin for burn reconstruction.However,the use of bioprinting for skin reconstruction following burns is promising;bioprinting will enable accurate placement of cell types and precise and reproducible fabrication of constructs to replace the injured or damaged sites.Overall,3D bioprinting is a very transformative technology,and its use for wound reconstruction will lead to a paradigm shift in patient outcomes.In this review,we aim to introduce bioprinting,the different stages involved,in vitro and in vivo skin bioprinting,and the various clinical and regulatory challenges in adoption of this technology. | Mathew Varkey Dafydd O.Visscher Paul P.Mvan Zuijlen Anthony Atala James J.Yoo | 2019 | Burns & Trauma2019，7，1： | 8 |
| 2 | Spontaneous gallbladder perforation,pericholecystic abscess and cholecystoduodenal fistula as the first manifestations of gallstone disease显示文摘BACKGROUND:Gallstone disease is common,and complications that are frequently encountered include acute cholecystitis and acute pancreatitis,but rarely gallbladder perforation. METHOD:Data were retrospectively collected from clinical case notes and a literature review is presented. RESULTS:A 72-year-old lady presented with spontaneous gallbladder perforation,pericholecystic abscess and cholecystoduodenal fistula as the first manifestations of gallstone disease.She was previously well and had no abdominal complaints.Her condition was successfully managed with initial antibiotic therapy followed by interval cholecystectomy and fistula repair. CONCLUSIONS:Our case highlighted some uncommon but severe complications which occurred simultaneously as the first manifestations of previously asymptomatic gallstone disease.Such complications need to be considered in patients suspected of intra-abdominal sepsis,even when there are no characteristic symptoms. | Vui Heng Chong Kian Soon Lim Varkey Vallickad Mathew | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 4 |
| 3 | Counting CD4^(+) and CD8^(+) T cells in the spleen: a novel in vivo method for assessing biomaterial immunotoxicity显示文摘As immunotoxicity assessments of newly developed biomaterials are often restricted to use in assessment of local tissue response at the implantation site,they do not always show an immune response acceptable to qualify them for clinical use.We tested a new method to assess systemic toxicity:counting the CD4^(+) and CD8^(+) cells in the spleen.Three different biomaterials were subcutaneously implanted in three groups of rats for the same time period.After 31 days,their spleens were harvested,and CD4^(+) and CD8^(+) cells were counted.The mean CD4^(+)/CD8^(+) cell counts were 24.563.6/19.864.0(porous collagen matrix group),25.567.1/21.663.8[synthetic collagen matrix(DuragenVR)group]and 28.164.1/19.663.7(porcine dermis group).Differences in cell counts were not significant.The immunotoxic response generated against porous collagen matrix was comparable to that produced by a similar biomaterial already used clinically.This is,to the best of our knowledge,the first study on cytotoxic lymphocytes in the spleen to quantify systemic immune response to a biomaterial;however,such studies have been conducted with bacterial and viral antigens,and with vaccines.We believe that the present study provides a viable method for larger studies to confirm our current findings. | Shyh-Jou Shieh Prashanth Varkey Po-Yang Chen Su-Ya Chang Lynn L.H.Huang | 2014 | Regenerative Biomaterials2014，1，1： | 3 |
| 4 | NEJM:埃博拉病毒可在康复者精液与眼睛中存活长达6个月显示文摘一个国际研究小组最新发现,埃博拉病毒不仅可在康复者精液里长时间存活,还能在康复者的眼睛里存活。研究人员说,这一发现凸显了对康复者进行眼部检查的必要性。 | Varkey JB Shantha JG Crozier I | 2015 | 疾病监测2015，30，5： | 2 |
| 5 | In vitro osteogenic response of rat bone marrow cells to bFGF and BMP-2 treatments显示文摘 | Varkey M Kucharski C Haque T | 2006 | Clin Orthop Relat Res2006，443，2： | 1 |
| 6 | 老年人急性心肌梗死的循证治疗方案:目前的观点 | Nanette Kass Wenger Tarek Helmy Bobby Varkey Khan Amar D.Patel | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 1 |
| 7 | Doulas as childbirth paraprofessionals:results from a national survey 显示文摘 | Lantz P M Low L K Varkey S | 2005 | Womens Health Issues2005，15，3： | 1 |
| 8 | Identification of anti- alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureusdermonecrosis and exhibit a correlation between affinity and potency 显示文摘 | Tkaczyk C Hua L Varkey R | 2012 | Clin Vaccine Immunol2012，19，3： | 1 |
| 9 | Differential collagene- glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts:Potential therapeutic targets for hypertrophic scar 显示文摘 | Varkey M Ding J Tredget EE | 2011 | Biomaterials2011，32，30： | 1 |
| 10 | Chronic obstructive pulmonary discase inwomen:exploring gender differences显示文摘 | Varkey AB | 2004 | Curr Opin Pulm Med2004，10，2： | 1 |
| 11 | Fuel regressionrate in hydroxyl-terminated-polybutadiene/gaseous-oxygenhybrid rocket motors显示文摘 | George P Krishnan S Varkey P M | 2001 | Journal of Propulsion and Pow-er2001，17，1： | 1 |
| 12 | In vitro osteogenic response af rat bone marrow cells to bFGF and BMP-2 treatments显示文摘 | Varkey M Kucharski C Haque T | 2006 | Clin Orthop Relat Res2006，443，2： | 1 |
| 13 | Laparoseopic diag- nosis and repair of asymptomatic bilateral inguinal hernias 显示文摘 | O'Rourke A Zell JA Varkey -Zell TY et at | 2002 | Am J Surg2002，183，1： | 1 |
| 14 | Phase study of oral eapecitabine in patients with advanced of metastatic pancreatic cancer 显示文摘 | Cartwright TH Cohn A Varkey JA | 2003 | J Clin Onco12003，20，： | 1 |
| 15 | 显示文摘 | Varkey A J Int | 1990 | J Mater Prod Technol1990，5，： | 1 |
| 16 | Physical oceanography of the Bay of Bengal and Andaman Sea显示文摘 | VARKEY M J MURTY V S N SURYANARAYANA A | 1996 | Oceanography and Marine Biology:an Annual Review1996，34，： | 1 |
| 17 | Using quality- improvement techniques to enhance patient education and counseling of diagnosis and management 显示文摘 | Varkey P Sathananthan A Scheifer A | 2009 | Qual Prim Care2009，17，3： | 1 |
| 18 | Spray pyrolised thin film CdS homojunction solar cell with improved performance显示文摘 | Varkey K P Vijayakumar K P Yoshida T | 1999 | Renewable Energy1999，18，： | 1 |
| 19 | In vitro osteogenic response of Rat bone marrow cells to bFGF and BMP-2 treatments 显示文摘 | Varkey M Kucharski C Haque T | 2006 | Clin Orthop Relat Res2006，443，： | 1 |
| 20 | A new synthetic route for the preparation of a new series of 14-22 membered tetraoxomacrocyclic tetraamines and their transition metal complexes 显示文摘 | SHAKIR M VARKEY S P | 1995 | Polyhedron1995，14，9： | 1 |
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