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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | A quantitative histochemical procedure for the demonstration of purine nucleoside phosphorylase activity in rat and human liver using Teranitro BT and xantheine oxidase as auxillary enzyme显示文摘 | Frederiks WM Bosch KS Gulik TM van | 1993 | Histochem J1993，25，1： | 2 |
| 4 | Photodynamic therapeutics:basic principles and clinical applications显示文摘 | Allen CM Van Lier JE | 1999 | Drug Discovery Today1999，4，： | 1 |
| 5 | Small Vessel Disease and General Cognitive Function in Non disabled Elderly the LADIS Study显示文摘 | vander Flier WM van Straaten EC Barkhof F | 2005 | Stroke2005，3，10： | 1 |
| 6 | Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis显示文摘 | Wegkamp A van Oorschot W de Vos WM | 2007 | Applied Environmental Microbiology2007，73，8： | 1 |
| 7 | Risk factors for ectopic pregnancy:a mata-analysis显示文摘 | Ankum WM Mol BW Van der Veen | 1996 | Fertil Steril1996，66，6： | 1 |
| 8 | The role of macrophages in Acanthamoeba keratitis显示文摘 | van Klink F Taylor WM Alizadeh H Jager MJ van Rooijen N Niederkorn JY | 1996 | Invest Ophthalmol Vis Sci1996，37，： | 1 |
| 9 | The role of gelatinases in colorectal cancer progression and metastasis 显示文摘 | Mook OR Frederiks WM Van Noorden CJ | 2004 | Biochim Biophys Acta2004，1705，2： | 1 |
| 10 | Progression of white matter hyperintensities and incedence of new lacunes over a 3-year period : the leukeariosisi and disabilty study 显示文摘 | Gouw AA van der Flier WM Fazekas F | 2008 | Stroke2008，39，： | 1 |
| 11 | Postprandial chylomicron clearance rate in late teenagers with diabetes mellitus type 1显示文摘 | van Waarde WM Odink RJ Rouwe C | 2001 | Pediatr Res2001，50，5： | 1 |
| 12 | TheWnt/frizzled/GSK-3p pathway : a novel therapeutic target forcardiac hypertrophy 显示文摘 | Blankesteijn WM van de Schans VA ter Horst P | 2008 | Trends Pharmacol Sci2008，29，4： | 1 |
| 13 | Does sleep depriva-tion alter functional EEG networks in children with focal epilep sy? 显示文摘 | van Diessen E Otte WM Braun KP | 2014 | Front Syst Neurosci2014，29，5： | 1 |
| 14 | Incidence and short-term outcome of acute lung injury in mechanically ventilated children显示文摘 | Dahlem P van Aalderen WM Hamaker ME | 2003 | Eur Respir J2003，22，： | 1 |
| 15 | The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania 显示文摘 | Ferwerda B Kibiki GS Netea MG Dolmans WM van der Ven AJ | 2007 | AIDS2007，21，10： | 1 |
| 16 | Incidence of opportunistic and other in-fections in HIV-infected children in the HAART era显示文摘 | Gona P Van Dyke RB Williams PL Dankner WM Chemcff MC Nachman SA | 2006 | JAMA2006，296，3： | 1 |
| 17 | Effects of lowdose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopansal women: a randomized placebo-controlled study显示文摘 | Post MS van der Mooren M J van Baal WM | 2003 | Am J Obstet Gyneco12003，189，5： | 1 |
| 18 | Photodynamic therapeutics: basic principles and clinical applications 显示文摘 | SHARMAN WM ALLEN CM VAN LIER JE | 1999 | Drug Discovery Today1999，4，11： | 1 |
| 19 | Human xenografi mod- els as useful tools to assess the potential of novel therapeutics in prostate cancer显示文摘 | Van Weerden WM Bangma C De Wit R | 2009 | Bri J Cancer2009，100，1： | 1 |
| 20 | The role of gelatinases in colorectal progression and metastasis显示文摘 | Mook OR Frederiks WM Van Noorden CJ | 2004 | Biochim Biophys Acta2004，1705，2： | 1 |
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