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| 1 | 欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南显示文摘恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。 | A. Scherpereel P. Astoul P. Baas T. Berghmans H. Clayson P. de Vuyst H. Dienemann F. Galateau-Salle C. Hennequin G. Hillerdal C. Le Pe'choux L. Mutti J-C. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆 徐萧洪 | 2010 | 中国肺癌杂志2010，，10： | 56 |
| 2 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 3 | The role of electrical stimulation in voiding dys- function 显示文摘 | Van Kerrebroeck PE | 1998 | Eur Urol1998，，： | 1 |
| 4 | Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact显示文摘 | Van den Steen PE Proost P Wuyts A | 2000 | Blood2000，96，： | 1 |
| 5 | A retro- spective comparison of the effects of propofol and etomidate on stimulus variables and efficacy ofelectroconvulsive therapy in de- pressed inpatients 显示文摘 | Graveland PE Wierdsma AI van den Brock WW | 2013 | Prog Neuropsychopharmacol Biol Psychia- try2013，45，1： | 1 |
| 6 | Bioche~nistry and molec- ular biology of gelatinase B or matrix mmetalloproteninase-9 (MMP-9) : The next decade 显示文摘 | Vandooren J Van den Steen PE Opdenakker G | 2013 | Crit Rev Biochem Mol Bid2013，48，3： | 1 |
| 7 | Retreatment withthe induction regimen in small cell lung cancer relapeing after initial response to short term chemotherapy 显示文摘 | Berendsen HH Van zandwijk N | 1987 | Eur J Cancer clin Oncol1987，23，9： | 1 |
| 8 | Using time-resolved fluorescence to measure serum venom-specific IgE and IgG显示文摘 | van Eeden PE Wiese MD Aulfrey S | | 0，，01： | 1 |
| 9 | Intrathecal ropivacaine for ambulatory sursery显示文摘 | Gantier PE De Kock M Van Steenberge A | 1999 | Anesthesiology1999，91，5： | 1 |
| 10 | Intrathecal ropivacaine for ambulatory surgery显示文摘 | Gautier PE de Kock M van Steenberge A | 1999 | Anesthesiology1999，91，5： | 1 |
| 11 | Gelatinase B functions as regulator and effector in leukocyte biology 显示文摘 | Opdenakker G Van den steen PE Duhois B | 2001 | J Leukoo Biol2001，69，6： | 1 |
| 12 | Peg - interferon im- proves liver histology in patients with HBeAg - positive chronic hepatitis B : no additional benefit of combination with lamivudine 显示文摘 | Van Zonneveld M Zondervan PE | 2006 | Liver Int2006，26，： | 1 |
| 13 | Targeting neutrophil collagenase/Matrix metalloproteinase-8 and gelatinase B/Matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock 显示文摘 | Hu J Van den Steen PE Dillen C | 2005 | Biochem Pharmacol2005，70，4： | 1 |
| 14 | Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock 显示文摘 | Hu J Van den Steen PE Dillen C | 2005 | Biochem Pharmacol2005，70，： | 1 |
| 15 | Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis显示文摘 | van Soolingen D Hermans PW de Haas PE | 1991 | J Clin Microbiol1991，29，11： | 1 |
| 16 | Early hemodynamic resuscitation in septic shock: understanding and modifying oxygen delivery显示文摘 | van Beest PA Spronk PE | 2014 | Crit Care2014，18，1： | 1 |
| 17 | Intrathecal ropivacaine for ambulatory surgery显示文摘 | Gautier PE De Kock M Van Steenberge A | 1999 | Anesthesiology1999，91，5： | 1 |
| 18 | Clinical applicatiom of nonculture based methods for the diagnosis and management of opportunistic and endemic mycoses显示文摘 | Verweij PE Figueroa J Van Burik J | 2000 | Med Mycol2000，38，1： | 1 |
| 19 | Endoscopic calcaneoplasty显示文摘 | Van Dijk CN Van Dyk CE Scholten PE | | 0，，02： | 1 |
| 20 | Bladder pressure sensors in an animal model 显示文摘 | Koldewijn EL Van Kerrebroeck PE Schaafsma E | 1994 | J Urol1994，151，5： | 1 |
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