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| 1 | How to(Easily)Extend the FAIRness of Existing Repositories显示文摘Data repository infrastructures for academics have appeared in waves since the dawn of Web technology.These waves are driven by changes in societal needs,archiving needs and the development of cloud computing resources.As such,the data repository landscape has many flavors when it comes to sustainability models,target audiences and feature sets.One thing that links all data repositories is a desire to make the content they host reusable,building on the core principles of cataloging content for economical and research speed efficiency.The FAIR principles are a common goal for all repository infrastructures to aim for.No matter what discipline or infrastructure,the goal of reusable content,for both humans and machines,is a common one.This is the first time that repositories can work toward a common goal that ultimately lends itself to interoperability.The idea that research can move further and faster as we un-silo these fantastic resources is an achievable one.This paper investigates the steps that existing repositories need to take in order to remain useful and relevant in a FAIR research world. | Mark Hahnel Dan Valen | 2020 | Data Intelligence2020，2，1： | 6 |
| 2 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 3 | 中国壁画颜料成分组成的探讨(英文)显示文摘中国壁画颜料的成分很复杂,应用历史也很长,唐代乾陵壁画是中国壁画技术应用的里程碑。本文研究源于三个公元8世纪的壁画,比较了中国古文中有关矿物颜料与植物染料的描述。当我致力于搞清各种颜料名称及成分时,我遇到了很大的困难,大量的颜料名称混杂不易辩别矿物颜料和有机颜料。壁画中大量应用的是本地产的矿物颜料,如:朱砂、赤土、孔雀石、蓝铜矿、雄黄、雌黄、高岭土、白垩土等。除了已知的矿物颜料和名称外,还有一些未确定的成分,如云母,很少在艺术史书籍中提及。壁画研究中最少涉入的领域是植物染料的应用,我认为植物染料是一种真正的壁画颜料,公元五世纪的书籍'起名要素'就是一个佐证。最重要的是,我从几种例子中发现了证据,就是植物成分与其它植物染料或矿物颜料混合应用在壁画中。本文希望能促进人们对不同物质在各种环境中习性的认识和了解,以期对保护实践活动有所帮助。我希望对壁画材料提一点自己的看法。 | Lucien van Valen | 2009 | 文博2009，，6： | 3 |
| 4 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 5 | Anthropology and tourism 显示文摘 | Dennison Nash Valene L Smith | 1991 | Annals of Tourism Research1991，18，1： | 1 |
| 6 | Nuclear factor kappa-B and the heart显示文摘 | Valen G Yan ZQ Hansson GK | 2001 | J Am Coil Cardial2001，38，： | 1 |
| 7 | Mind the gap: Impact of computational fluid dynamics solution strategy on prediction of intracranial aneurysm hemodynamics and rupture status indicators显示文摘 | VALEN S K STEINMAN D A | 2014 | American Journal of Neuro- radiology2014，35，3： | 1 |
| 8 | Saponins from the roots of Chiococca alba and their in vitro anti-inflammatory activity显示文摘 | Borges RM Valen?a SS Lopes AA | 2013 | Phytochemistry Letters2013，6，1： | 1 |
| 9 | Anthropology and tourism 显示文摘 | Dennison Nash Valene L Smith | 1991 | Annals of Tourism Research1991，18，1： | 1 |
| 10 | Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis 显示文摘 | Pauli A Valen E Lin MF | 2012 | Genome Res2012，22，3： | 1 |
| 11 | Nucler Factor Kappa- B and the heart显示文摘 | Valen G Yah Z Hansson GK | 2001 | JACC2001，38，2： | 1 |
| 12 | induction of inflammatory media- tors During reperfusion of the human heart显示文摘 | Valen G Paulsson G Vange J | 2001 | Ann Thorac surg2001，71，1： | 1 |
| 13 | Nuclear factor kappa-B and the heart 显示文摘 | Valen G Yan ZQ Hansson GK | 2001 | J Am Coll Cardiol2001，38，2： | 1 |
| 14 | Induction of inflammatory mediators during reperfusion of the human heart显示文摘 | Valen G Paulsson G Veage J | 2001 | Ann Yhorac Surg2001，71，1： | 1 |
| 15 | Nuclear factor kappa-B and the heart 显示文摘 | Valen G Yan Z Q Hansson G K | 2001 | J Am Coll Cardial2001，38，2： | 1 |
| 16 | Morphological variation and width of ecological niche显示文摘 | van Valen L M | 1965 | American Naturalist1965，99，3： | 1 |
| 17 | Signal transduetion through nuclear factor kappa B in ischemia - reperfusion and heart failure显示文摘 | Valen G | 2004 | Basic Research in Cardiology2004，99，1： | 1 |
| 18 | Cluster headache and intracranial aneurysm显示文摘 | Valen?a MM Andrade-Valen?a LP Martins C etal | 2007 | JHeadache Pain2007，8，： | 1 |
| 19 | HTERT expression in sporadic renal ceil carcinomas 显示文摘 | Valene Paradis Ivan Bieche Delphine Dargere | 2001 | J Pathol2001，195，： | 1 |
| 20 | Signal transduction through nuclear factor kappa B in ischemia reperfusion and heart failure显示文摘 | Valen G | 2004 | Basic Res Cardiol2004，99，1： | 1 |
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