|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predicting(side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics显示文摘Inflammatory bowel disease (IBD) is a chronic and heterogeneous intestinal inflammatory disorder. The medical management of IBD aims for long-lasting disease remission to prevent complications and disease progression. Early introduction of immunosuppression forms the mainstay of medical IBD management. Large inter-individual variability in drug responses, in terms of both efficacy and toxicity, leads to high rates of therapeutic failure in the management of IBD. Better patient stratification is needed to maximize patient benefit and minimize the harm caused by adverse events. Pre-treatment pharmacogenetic testing has the potential to optimize drug selection and dose, and to minimize harm caused by adverse drug reactions. In addition, optimizing the use of cheap conventional drugs, and avoiding expensive ineffective drugs, will lead to a significant reduction in costs. Genetic variation in both TPMT and NUDT15, genes involved in thiopurine metabolism, is associated to an increased risk of thiopurine-induced myelosuppression. Moreover, specific HLA haplotypes confer risk to thiopurine-induced pancreatitis and to immunogenicity to tumor necrosis factor-antagonists, respectively. Falling costs and increased availability of genetic tests allow for the incorporation of pre-treatment genetic tests into clinical IBD management guidelines. In this paper, we review clinically useful pharmacogenetic associations for individualized treatment of patients with IBD and discuss the path from identification of a predictive pharmacogenetic marker to implementation into IBD clinical care. | Michiel Dirk Voskuil Amber Bangma Rinse Karel Weersma Eleonora Anna Margaretha Festen | 2019 | World Journal of Gastroenterology2019，25，21： | 2 |
| 2 | 血压难以控制的高血压患者临时停用降压药的安全性分析显示文摘血压控制成功依赖于有效鉴别出继发性病因和发现高血压的发病因素。由于抗高血压药物可能会干扰诊断调查,在一些研究中可能会要求患者临时停药。然而,对于血压难以控制的高血压患者,临时停用抗高血压药物的安全性令人担忧。 | 刘莉 叶鹏 Beeftink MM van der Sande NG Bots ML Doevendans PA Blankestijn PJ Visseren FL Voskuil M Spiering W | 2017 | 中华高血压杂志2017，25，4： | 2 |
| 3 | A gene-expression signature as a predictor of survival in breast cancer 显示文摘 | van de Vijver MJ He YD van't Veer LJ Dai H Hart AA Voskuil DW | 2002 | N Engl J Med2002，347，25： | 1 |
| 4 | The - 16 region of Bacillus subtilis and other gram- positive bacterial promoters显示文摘 | Voskuil M Chambliss G | 1998 | Nucleic Acids Research1998，26，15： | 1 |
| 5 | Physical Activity and Endometrial Cancer Risk, a Systematic Review of Current Evidence 显示文摘 | Dorien Voskuil Evelyn M Monninkhof Sjoerd G | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，4： | 1 |
| 6 | The Mycobac-terium tuberculosis ECF sigma factor σE: role in global gene ex- pression and survival in macrophages显示文摘 | Manganelli R Voskuil MI Schoolnik GK | 2001 | Mol Microbiol2001，41，： | 1 |
| 7 | IdeR, an essential gene in Myeobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response 显示文摘 | Rodriguez GM Voskuil MI Gold B | 2002 | Infect Immun2002，70，7： | 1 |
| 8 | Percutaneous renal denervation for the treatment of resistant essential hypertension;the first Dutch experience显示文摘 | Voskuil M Verloop WL Blankestijn PJ | | 0，，： | 1 |
| 9 | Percutaneous renal denervation for the treatment of resistant essential hypertension; the first Dutch experience显示文摘 | Voskuil M Verloop WL Blankestijn PI | 2011 | Neth Heart J2011，19，78： | 1 |
| 10 | Postsurgical course of patients with congenitally corrected transposition of the great arteries 显示文摘 | Voskuil M Hazekamp MG Kroft IAM | 1999 | Am J Cardiol1999，83，4： | 1 |
| 11 | Invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease显示文摘 | Buschmann IR Voskuil M van Royen N | | 0，，： | 1 |
| 12 | Transcriptional adaptation of Mycobacterium tuberculosis within macrophages, insights into the phagosomal environment 显示文摘 | Schnappinger D Ehrt S Voskuil MI | 2003 | J Exp Med2003，198，5： | 1 |
| 13 | Comparative expression studies of a complex phenotype: cord formation in Mycobacterium tuberculosis 显示文摘 | Gao Q Kripke K Arinc Z Voskuil M Small P | 2004 | Tuberculosis (Edinb)2004，84，34： | 1 |
| 14 | Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program 显示文摘 | VOSKUIL MI SCHNAPPINGER D VISCONTI KC | 2003 | J Exp ned2003，198，5： | 1 |
| 15 | Percutaneous renaldenervation for the treatment of resistant essential hypertension;thefirst Dutch experience显示文摘 | Voskuil M Verloop W L Blankestijn P J | 2011 | Neth Heart J2011，19，78： | 1 |
| 16 | Percutaneous renal denervation for the treatment of resistant essential hypertension; the first Dutch experience显示文摘 | Voskuil M Verloop WL Blankestijn PJ | 2011 | Neth Heart J2011，19，： | 1 |
| 17 | Regulation of the mycobacterium tuberculosis显示文摘 | Voskuil MI Schnappinger D Rutherford R | 2004 | Tuberculosis2004，84，： | 1 |
| 18 | Modulation of collateral artery growth in a porcine hindlimb ligation model usingMCP-1 显示文摘 | Voskuil M Van Royen N Hoefer IE | 2003 | AmJPhysiol Heart Circ Physiol2003，284，4： | 1 |
| 19 | Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program显示文摘 | Voskuil MI Schnappinger D Visconti KC | 2003 | J Exp Med2003，198，5： | 1 |
| 20 | 显示文摘 | Arens J F | 1963 | Rec Trav Chim1963，82，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员