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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | CDKN2A promoter methylation in gastric adenocarcinomas:clinical variables显示文摘 | Vo Q N Geradts J Boudreau D A | 2002 | Hum Pathol2002，33，12： | 1 |
| 3 | Blade tip clearanceflow and compressor nonsynchronous vibrations : the jetcore feedback theory as the coupling mechanism显示文摘 | Thomassin J Vo H D Mureithi N W | 2009 | Jour-nal of Turbomachinery2009，131，01： | 1 |
| 4 | Platelet wash-ing to prevent recurrent febrile reactions to leucocyte-reduced transfusion 显示文摘 | VO T D COWLES J HEAL J M | 2001 | Transfusion2001，11，： | 1 |
| 5 | The tip clearanceflow resonance behind axial compressor monsynchronousvibration显示文摘 | Thomassin J Vo H D Mureithi N W | 2011 | Journal of Turbomachinery2011，133，04： | 1 |
| 6 | Crystal growth of LiO2as a cathode material for high-performance lithium ion batteries显示文摘 | Zhu J Vo T Li D | 2012 | Crystal Growth&Design2012，12，3： | 1 |
| 7 | Surfactant-en- hanced removal of Cu( II ) and Zn( H ) from a contaminated sandy soil显示文摘 | RAMAMURTHY A S VO D LI X J | 2008 | Water Air and Soil Pollution2008，190，1234： | 1 |
| 8 | A random-finite-set approach to Bayesian SLAM 显示文摘 | Mullane J Vo Ba-Ngu Adams M D Vo Ba- Tuong | 2011 | IEEE Transactions on Robotics2011，27，2： | 1 |
| 9 | Performance Predictions for Gas-condensate Reservoirs显示文摘 | Vo D T Jones J R Raghavan R | 1989 | SPEFE1989，，： | 1 |
| 10 | Surfactant-enhanced removal of Cu(Ⅱ) and Zn(Ⅱ)from a contaminated sandy soil显示文摘 | Ramamurthy A S Vo D Li X J | 2008 | Water Air Soil Pollut2008，190，： | 1 |
| 11 | A random-finite-set approach to bayesian SLAM显示文摘 | MULLANE J VO B N MARTIN D | 2011 | IEEE Transactions on Robotics2011，27，2： | 1 |
| 12 | Palladium-catalyzed coupling ofammonia with aryl chlorides, bromides, iodides, and sulfon- ates:a general method for the preparation of primary aryl- amines显示文摘 | Vo G D Hartwig J F | 2009 | J Am Chem Soc2009，131，11： | 1 |
| 13 | Identifying inflammatory targets for bio- logic therapies for spine pain 显示文摘 | Jacobs L J Vo N Kang J D | 2011 | PM R2011，3，6： | 1 |
| 14 | Soil water content and organic carbon availability are major determinants of soil microbial community composition显示文摘 | Drenovsky R E Vo D Graham K J | 2004 | Microb Ecol2004，48，： | 1 |
| 15 | CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables 显示文摘 | Vo Q N Geradts J Boudreau D A | 2002 | Hum Pathol2002，33，12： | 1 |
| 16 | Numerical and experimental study of dividing open-channel flows显示文摘 | Ramamurthy A S Qu J Vo D | 2007 | Journal Hydraulic Engineering2007，133，10： | 1 |
| 17 | Numerical and experimental study of dividing open-channel flows显示文摘 | RAMAMURTHY A S QU J Y VO D | 2007 | Journal of Hydraulic Engineering ASCE2007，133，10： | 1 |
| 18 | Surfactant-enhanced removal of Cu( II ) and Zn( II ) from a contaminated sandy soil 显示文摘 | Ramamurthy A S Vo D Li X J | 2008 | Water Air & Soil Pollution2008，190，14： | 1 |
| 19 | Surfactant-enhanced re- moval of Cu and Zn from a contaminated sandy soil 显示文摘 | Ramamurthy A S Vo D Li X J | 2008 | Water Air Soil Pollut2008，190，： | 1 |
| 20 | Simultaneous multi-impairment monitoring of 640 Gbit/s signals using photonic chip based RF spectrum analyzer 显示文摘 | VO T D PELUSI M D SCHRODER J | 2010 | Optics Express2010，18，4： | 1 |
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