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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Acute diarrhea in west african children: diverse enteric viruses and a novel parvovirus ge- nus显示文摘 | Phan TG Vo NP Bonkoungou I J | 2012 | J Virol2012，86，11： | 1 |
| 3 | High level of ciprofloxacin resistance and its molecular background among Campylobacter jejuni strains isolated in the United Arab Emirates 显示文摘 | Sonnevend A Rotimi VO Kolodziejek J | 2006 | J Med Microbiol2006，15，： | 1 |
| 4 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
| 5 | CDKN2A promoter methylation in gastric adenocarcinomas:clinical variables显示文摘 | Vo Q N Geradts J Boudreau D A | 2002 | Hum Pathol2002，33，12： | 1 |
| 6 | Platelet washing to prevent recurrent febrile reactions to leukocyte-reduced transfusions显示文摘 | Vo TD Cowles J Heal JM | 2001 | Transfusion Med2001，11，1： | 1 |
| 7 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 8 | Blade tip clearanceflow and compressor nonsynchronous vibrations : the jetcore feedback theory as the coupling mechanism显示文摘 | Thomassin J Vo H D Mureithi N W | 2009 | Jour-nal of Turbomachinery2009，131，01： | 1 |
| 9 | Platelet wash-ing to prevent recurrent febrile reactions to leucocyte-reduced transfusion 显示文摘 | VO T D COWLES J HEAL J M | 2001 | Transfusion2001，11，： | 1 |
| 10 | The tip clearanceflow resonance behind axial compressor monsynchronousvibration显示文摘 | Thomassin J Vo H D Mureithi N W | 2011 | Journal of Turbomachinery2011，133，04： | 1 |
| 11 | Polyelonal rabbit antithymo- cyte globulin triggers B - celland plasma cell apoptosis by multiple pathways显示文摘 | Zand MS Vo T Huggins J | 2005 | Transplantation2005，79，11： | 1 |
| 12 | Crystal growth of LiO2as a cathode material for high-performance lithium ion batteries显示文摘 | Zhu J Vo T Li D | 2012 | Crystal Growth&Design2012，12，3： | 1 |
| 13 | Intramuscular injections into the b'attocks: are they truly intramuscular 显示文摘 | Chan VO Colville J Persaud T | 2006 | Eur J Radiol2006，58，3： | 1 |
| 14 | Favorable long-term results of prosthetic arthroplasty of the knee for distal femur neoplasms显示文摘 | Frink SJ Rutledge J Lewis VO | 2005 | Clin Orthop Relat Res2005，438，9： | 1 |
| 15 | Cyclooxygenase-2 regulates survival,migration,and invasion of human endometriotic cells through multiple mechanisms显示文摘 | Banu SK Lee J Speights VO Jr | 2008 | Endocrinology2008，149，3： | 1 |
| 16 | Platelet washing to pre- vent febrile reactions to leucoeyle-redueed transfusion 显示文摘 | Vo TD Cowles J Heal JM | 2001 | Transfus Med2001，11，： | 1 |
| 17 | Protein kinase C- fdeltaf regulates the subcellular localization of Shc in H202-treated cardiomyocytes显示文摘 | Guo J Cong L Rybin VO | 2010 | Am J Physiol Cell Physiol2010，299，77： | 1 |
| 18 | Impact Severity of Local Recurrence in Giant Cell Tumor of Bone显示文摘 | McGough RL Rutledge J Lewis VO | 2005 | Clin Orthop Relat Res2005，438，： | 1 |
| 19 | Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms显示文摘 | Banu SK Lee J Speights VO Jr | 2008 | Endocrinology2008，149，3： | 1 |
| 20 | Z- microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy显示文摘 | Shan VO Seavini M Nilolie J | 2006 | J Clin Endocrional Metab2006，83，： | 1 |
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