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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Cross sections calculations for electron oxygen scattering using the polarized orbital close coupling theory 显示文摘 | Vo Ky Lan Feautrier N Le Dourneuf M Regemorter H Van | 1972 | J Phys B1972，5，： | 1 |
| 3 | Massel Experiments on wavemotion and suspended sediment concentration at Nang Hai,Can Gio mangrove forest, Southern Viet- nam显示文摘 | Vo Luong H P | 2006 | Oeeanologia2006，48，1： | 1 |
| 4 | Magnetic resonance cerebral metabolic rate of oxygen utilization in hyperacute stroke patients显示文摘 | Lee JM Vo KD An H | 2003 | Ann Neurol2003，53，2： | 1 |
| 5 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
| 6 | Calbindin-D9k as a sensitive mo- lecular biomarker for evaluating the synergistic impact of estrogenic chemicals on GH3 rat pituitary cells显示文摘 | Vo TT An BS Yang H | 2012 | Int J Mol Med2012，30，5： | 1 |
| 7 | Blade tip clearanceflow and compressor nonsynchronous vibrations : the jetcore feedback theory as the coupling mechanism显示文摘 | Thomassin J Vo H D Mureithi N W | 2009 | Jour-nal of Turbomachinery2009，131，01： | 1 |
| 8 | Role of blade pas sage flow structures in axial compressor rotating stall in ception显示文摘 | Hoying D A Tan C S Vo H D | 1999 | Journal of Turbomachinery1999，121，4： | 1 |
| 9 | The tip clearanceflow resonance behind axial compressor monsynchronousvibration显示文摘 | Thomassin J Vo H D Mureithi N W | 2011 | Journal of Turbomachinery2011，133，04： | 1 |
| 10 | Chronic hepatitis B infection: long term comparison of children receiving interferon alpha and untreated controls显示文摘 | Vo Thi Diem H Bourgois A Bontems P | 2005 | J Pediatr Gastroenterol Nutr2005，40，2： | 1 |
| 11 | Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in pichia pastoris 显示文摘 | Rydberg E H Sidhu G Vo H C | 1999 | Protein Science1999，8，3： | 1 |
| 12 | Marine food-derived functional ingredients as potential antioxidants in the food industry: An overview显示文摘 | Ngo D H Wijesekara I Vo T S | 2011 | Food Research International2011，44，2： | 1 |
| 13 | Enhancements of Authenticated Multiple Key Exchange Protocol Based on Bilinear Pairings显示文摘 | Vo D L Lee H Yeun C Y | 2010 | Computers and Electrical Engineering2010，36，1： | 1 |
| 14 | Biological activities and potential health benefits of bioactive peptides derived from marine organisms 显示文摘 | NGO D H VO T S NGO D N | 2012 | Int J Biol Maeromol2012，51，4： | 1 |
| 15 | A Gaussian mixture PHD filter for jump markov system models 显示文摘 | PANSHA S A BA-VGU Vo TUAN H D | 2009 | IEEE Trans on Aerospace and Electronic Systems2009，45，3： | 1 |
| 16 | Role of Blade Pas- sage Flow Structures in Axial Compressor Rotating Stall Inception 显示文摘 | Hoying D A Tan C S Vo H D | 1999 | ASME Journal of :rbomachinery1999，121，4： | 1 |
| 17 | Criteria for Spike Initi- ated Rotating Stall 显示文摘 | Vo H D Tan C S Greitzer E M | 2008 | Journal of Turbomachinery2008，130，： | 1 |
| 18 | Cytotoxic coumarinsfrom the bark of mammeasiamensis显示文摘 | Ngo N T Nguyen V T Vo H V | 2010 | Chem Pharm Bull(Tokyo)2010，58，11： | 1 |
| 19 | Criteria for Spike Ini- tiated Stall 显示文摘 | Vo H D Tan C S Greitzer E M | 2008 | ASME Journal of Turbomachinery2008，130，1： | 1 |
| 20 | Calbindin-D9k as a sensitive molecular biomarker for evaluating the synergistic impact of estrogenic chemicals on GH3 rat pituitary cells显示文摘 | VO T T B AN B S YANG H | 2012 | International Journal of Molecular Medicine2012，30，5： | 1 |
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