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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 3 | Sequential monte carlomethods for multi-target filtering with random finite sets显示文摘 | Vo B N Sumeetpal S S Arnaud D | 2005 | IEEE Transactions on Aerospace and Electronic Systems2005，41，4： | 1 |
| 4 | CDKN2A promoter methylation in gastric adenocarcinomas:clinical variables显示文摘 | Vo Q N Geradts J Boudreau D A | 2002 | Hum Pathol2002，33，12： | 1 |
| 5 | The incidence of unsuspected metastases from clinically benign prostate glands with latent prostate carcinoma显示文摘 | Brawn PN Kuhl D Speights VO | 1995 | Arch Pathol Lab Med1995，119，： | 1 |
| 6 | A consistent metric for performance evaluation of multi-object filters 显示文摘 | Schuhmacher D Vo B-T Vo B-N | 2008 | IEEE Transactions on Signal Processing2008，56，8： | 1 |
| 7 | Data association and track management for the Gaussian mixture probability hypothesis density filter显示文摘 | Panta K Clark D E and Vo B N | 2009 | IEEE Transactions on Aerospace andElectronic Systems2009，45，3： | 1 |
| 8 | Container terminal operation and operations research : A classification and literature review 显示文摘 | Steenken D Voβ S Stahlbock R | 2004 | OR Spectrum2004，26，1： | 1 |
| 9 | Investigation of the effects of peppermint oil and valerian on rat liver and cultured human liver cells显示文摘 | Vo L T Chan D King R G | 2003 | Clin Exp Pharmacol Physiol2003，30，10： | 1 |
| 10 | Bayesian multi-object filtering with amplitude feature likelihood for unknown object SNR 显示文摘 | Clark D E Ristic B Vo Ba-Ngu | 2010 | IEEE Transactions on Signal Processing2010，58，1： | 1 |
| 11 | A consistent metric forperformance evaluation of multi-object filters显示文摘 | Schuhmacher D Vo B T and Vo B N | 2008 | IEEE Transactions on Signal Processing2008，56，8： | 1 |
| 12 | Inflammatory and catabolic signalling in intervertebral discs:the roles of NF-κB and MAP kinases显示文摘 | Wuertz K Vo N Kletsas D | | 0，，： | 1 |
| 13 | Blade tip clearanceflow and compressor nonsynchronous vibrations : the jetcore feedback theory as the coupling mechanism显示文摘 | Thomassin J Vo H D Mureithi N W | 2009 | Jour-nal of Turbomachinery2009，131，01： | 1 |
| 14 | A metric for performance evaluation of multi-target tracking algorithms显示文摘 | RISTIC B VO B N CLARK D | 2011 | IEEE Transactions on Signal Processing2011，59，7： | 1 |
| 15 | Role of blade pas sage flow structures in axial compressor rotating stall in ception显示文摘 | Hoying D A Tan C S Vo H D | 1999 | Journal of Turbomachinery1999，121，4： | 1 |
| 16 | A consistent metric forperformance evaluation of multi-object filters显示文摘 | Schuhmacher D Vo B T Vo B N | 2008 | IEEETransactions on Signal Processing2008，56，8： | 1 |
| 17 | Platelet wash-ing to prevent recurrent febrile reactions to leucocyte-reduced transfusion 显示文摘 | VO T D COWLES J HEAL J M | 2001 | Transfusion2001，11，： | 1 |
| 18 | Advances in the management of coronary chronic total occlusions 显示文摘 | Brilakis ES Karmpaliotis D Vo MN | 2014 | J Cardiovasc Transl Res2014，7，4： | 1 |
| 19 | The tip clearanceflow resonance behind axial compressor monsynchronousvibration显示文摘 | Thomassin J Vo H D Mureithi N W | 2011 | Journal of Turbomachinery2011，133，04： | 1 |
| 20 | Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosus显示文摘 | Puntmann VO D'Cruz D Smith Z | 2013 | Circ Cardiovasc Imaging2013，6，2： | 1 |
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