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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 3 | High-efficiency Agrobacterium-mediated transformation of Brachypodium distachyon inbred line Bd21-3 显示文摘 | Vogel J Hill T | 2008 | Plant Cell Report2008，27，： | 1 |
| 4 | Abiotic and Biotic Trans-formations of 1,1,1-Trichloroethane under MethanogenicConditions显示文摘 | VOGEL T M MCCARTY P L | 1987 | Environmental Science and Technology1987，21，12： | 1 |
| 5 | 10Be profiles in sea water显示文摘 | KUSAKABE M KU T L VOGEL J | 1982 | Nature1982，299，： | 1 |
| 6 | Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabldopsis 显示文摘 | Vogel J T Zarka D G Van Buskirk H A | 2005 | Plant J2005，41，： | 1 |
| 7 | RNomics in Escherichia coil detects new sRNA species and indicates parallel transcriptional output in bacteria显示文摘 | Vogel J Bartels V Tang T H | 2003 | Nucleic Acids Res2003，31，22： | 1 |
| 8 | Carbon distribution and aboveground net primary production in aspen,jack pine,and black spruce stands in Saskatchewan and Manitoba,Canada显示文摘 | Gower S T Vogel J G Norman J M | 1997 | J Geophys Res1997，102，29： | 1 |
| 9 | Roles of the CBF2 and ZAT 12 transcription factors in configuring the 10w temperature transcriptome of Arabidopsis显示文摘 | Vogel J T Zarka D G Van Buskirk H A | 2005 | Plant J2005，41，： | 1 |
| 10 | Monocyte Chemoat- tractant Protein--1 Induces Proliferation and Interleukin--6 Production in Human Smooth Muscle Cells by Differential Activation of Nuclear Factor-- nB and Activator Protein-- 1 显示文摘 | Viedt C Vogel J Athanasiou T | 2002 | Arterioscler Thromb Vasc Biol2002，22，6： | 1 |
| 11 | A systematic review of psychologic factors as predictors of chronicity/disability in prospective cohorts of low back pain显示文摘 | Pincus T Burton A K Vogel S | 2002 | Spine2002，27，5： | 1 |
| 12 | Percutaneous treatment of displaced intra-articular calcaneal fractures显示文摘 | Schepers T Schipper IB Vogels LM | 2007 | J Orthop Sci2007，12，1： | 1 |
| 13 | Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1显示文摘 | VIEDT C VOGEL J ATHANASIOU T | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 14 | Enhancement of antimicrobial effects by glucoeorticoids 显示文摘 | TtirckJ Oberdfirfer C Vogel T | 2005 | Med Mierobiol Immuno12005，194，12： | 1 |
| 15 | Use of the Voigt function in a single-line method for the analysis of X-ray diffraction line broadening 显示文摘 | de KEUSER T H LANGFORD J I MITTEMEUER E J VOGELS A B P | 1982 | Journal of Applied Crystallography1982，15，： | 1 |
| 16 | The heart and pediatric rheumatology显示文摘 | Vogel T Kitcharoensakkul M Fotis L | 2014 | Rheum Dis Clin Noah Am2014，40，1： | 1 |
| 17 | Applying spatially resolved concentration and temper- ature measurements in a catalytic plate reactor for the ki- netic study of CO methanation 显示文摘 | KOPYSCINSKI J SCHILDHAUER T J VOGEL F | 2010 | Journal of Catalysis2010，271，2： | 1 |
| 18 | Acoustic emission for monitoring a reinforced concrete beam subject to four-point-bending 显示文摘 | Schechinger B Vogel T | 2007 | Construction and Building Materials2007，21，： | 1 |
| 19 | PMR6 a pectate lyase-like gene required for powdery mildew susceptibility in Arabidopsis 显示文摘 | Vogel J P Raab T K Schiff C | 2002 | Plant cell2002，14，： | 1 |
| 20 | Fast al- gorithms for phase diversity-based blind deconvolu- tion 显示文摘 | VOGEL C R CHAN T PLEMMONS R | 1998 | SPIE1998，3353，： | 1 |
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