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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Low kickback noise techniques for CMOS latched comparators显示文摘 | FIGUEIREDO P M VITAL J C | 2004 | IEEE ISCAS2004，1，： | 1 |
| 3 | Biochemical approach to di- agnosis and differentiation of primary hyperoxalurias: an update 显示文摘 | Petrarulo M Vitale C Facchini P | 1998 | J Nephrol1998，1，1： | 1 |
| 4 | Venous thromboembo- lism and lung cancer: a review显示文摘 | Vitale C D'Amato M Calabrb P | 2015 | Muhidiscip Respir Med2015，10，1： | 1 |
| 5 | Novel synthesis of 3, 4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal显示文摘 | Di N L Vitale P Scilimati A | 2004 | JMed Chem2004，47，20： | 1 |
| 6 | Aliasing effects mitigation by optimized sampling grids and impact on image acquisition chains 显示文摘 | VITALLI R BELLO U D ARMBRUSTER P | 2002 | IEEE2002，，： | 1 |
| 7 | Familial prion disease with a novel 144-bp insertion in the prion protein gene in a Basque family显示文摘 | Capellari S Vital C Parchi P | 1997 | Neurology1997，49，： | 1 |
| 8 | Selective Cyclooxygenase-1 inhibition by P6 and gastrotoxicity: preliminary investigation显示文摘 | Perrone M G Lofrumento D D Vitale P | 2015 | Pharmacology2015，95，12： | 1 |
| 9 | Body position changes redistribute lung computed tomographic density in patients with acute respiratory failure显示文摘 | GATTINONI L PELOSI P VITALE G | 1991 | Anesthesiology1991，74，1： | 1 |
| 10 | The development of targeted thera- pies in rheumatoid arthritis显示文摘 | Vital EM Emery P | 2008 | J Autoimmun2008，31，3： | 1 |
| 11 | CD34~ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells 显示文摘 | Vacca P Vitale C Montaldo E | 2011 | Proc Natl Acad Sci USA2011，108，： | 1 |
| 12 | The coagulopathy in sepsis:significance and implications for treatment显示文摘 | Saracco P Vitale P Scolfaco C | 2011 | Pediatr Rep2011，3，： | 1 |
| 13 | Olfactory mucosa auto grafts in human spinal cord injury: a pilot clinical study 显示文摘 | Lima C Pratas -Vital J Escada P | 2006 | J Spinal Cord Med2006，29，3： | 1 |
| 14 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 15 | The STEP mission:prin-ciples and baseline design显示文摘 | Mester J Torii R Worden P Lockerbie N Vitale S Everitt C W F | 2001 | Classical and Quantum Gravity2001，18，： | 1 |
| 16 | What IT infrastructure capabilities are needed to implement e - business models? 显示文摘 | P WEILL M VITALE | 2002 | MIS Quarterly Executive2002，1，1： | 1 |
| 17 | Negative resistance induced by avalanche injection in bulk semiconductors 显示文摘 | Caruso A Spirito P Vitale G | 1974 | IEEE Trans Electron Device1974，21，： | 1 |
| 18 | Applications of hybrid reachability analysis to robotic aerial vehicles显示文摘 | Gillula J H Hoffmann G M Huang H Vitals M P Tomlin C J | 2011 | International Journal of Robotics Research2011，30，3： | 1 |
| 19 | Assessment of OCT measurements as prognostic factors in my- opic macular hole surgery without foveoschisis 显示文摘 | Alkabes M Padilla L Salinas C Nucci P Vitale L Pichi F | 2013 | Graefes Arch Clin Exp Ophthalmo12013，251，11： | 1 |
| 20 | MSC andinnate immune cell interactions:A lesson from humandecidua显示文摘 | Vacca P Montaldo E Vitale C | 2015 | Immunol Lett2015，，： | 1 |
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