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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer显示文摘AIM: To investigate the antineoplastic potency of the novel insulin-like growth factor 1 receptor (IGF-1R) tyro- sine kinase inhibitor (TKI) NVP-AEW541 in cell lines and primary cell cultures of human colorectal cancer (CRC). METHODS: Cells of primary colorectal carcinomas were from 8 patients. Immunostaining and crystal violet stain- ing were used for analysis of growth factor receptor pro- tein expression and detection of cell number changes, respectively. Cytotoxicity was determined by measuring the release of the cytoplasmic enzyme lactate dehydro- genase (LDH). The proportion of apoptotic cells was determined by quantifying the percentage of sub-G1 (hypodiploid) cells. Cell cycle status reflected by the DNA content of the nuclei was detected by flow cytometry. RESULTS: NVP-AEW541 dose-dependently inhibited the proliferation of colorectal carcinoma cell lines and primary cell cultures by inducing apoptosis and cell cycle arrest. Apoptosis was characterized by caspase-3 activa- tion and nuclear degradation. Cell cycle was arrested at the G1/S checkpoint. The NVP-AEW541-mediated cell cycle-related signaling involved the inactivation of Akt and extracellular signal-regulated kinase (ERK) 1/2, the upregulation of the cyclin-dependent kinase inhibitors p21Waf1/CIP1 and p27Kip1, and the downregulation of the cell cycle promoter cyclin D1. Moreover, BAX was upregu- lated during NVP-AEW541-induced apoptosis, whereas Bcl-2 was downregulated. Measurement of LDH release showed that the antineoplastic effect of NVP-AEW541 was not due to general cytotoxicity of the compound. However, augmented antineoplastic effects were ob-served in combination treatments of NVP-AEW541 with either 5-FU, or the EGFR-antibody cetuximab, or the HMG-CoA-reductase inhibitor fluvastatin. CONCLUSION: IGF-1R-TK inhibition is a promising novel approach for either mono- or combination treatment strategies of colorectal carcinoma and even for CRC che- moprevention. | Michael Hpfner Andreas P Sutter Alexander Huether Viola Baradari Hans Scherübl | 2006 | World Journal of Gastroenterology2006，12，35： | 10 |
| 3 | Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer显示文摘瞄准:在肝细胞癌(HCC ) 检验导致 erlotinib 的生长抑制的内在的机制。方法:在基因表示的导致 Erlotinib 的改变用 cDNA 数组技术被评估;在蛋白质表示或蛋白质激活的变化用西方的弄污由于象 IGF-1-induced EGFR transactivation 一样的 erlotinib 治疗被调查。结果:Erlotinib 治疗禁止了 mitogen 激活和抄写(STAT ) 的激活的蛋白质(地图)-kinase 小径和信号变换器调停了表明哪个导致了调整由 cDNA 数组技术示威了的基因的 apoptosis 和房间周期的一个改变的表达式。象与象 Bcl-2, Bcl-X (L) 或 jun D 一样的 antiapoptotic 因素的一条下面规定联系的 caspases 和 gadds 一样的 proapoptotic 因素的 Overexpression 说明了让 erlotinib 的力量导致 apoptosis。支持 G1/S-transition 的房间周期管理者并且在 cyclin 依赖的激酶禁止者和 gadds 的表示上的 Downregulation 响应 erlotinib 贡献了 G1/G0-arrest 的正式就职。而且,我们显示了由 IGF-1-receptor 的调停 EGFR 的发信号的 transactivation 并且在受体受体十字谈话显示出 erlotinib 的禁止的效果。结论:我们的学习在 HCC 房间和 thus 使 EGFR-TK-inhibition 的行动的机制的理解清楚些可能便于 additively 或 synergistically 行动的联合治疗的设计。而且,我们对 erlotinib 处理作出回应的小径上的数据能在以后预言肿瘤的应答的海角到 EGFR-TKIs 是有用的。 | Alexander Huether Michael Hpfner Andreas P Sutter Viola Baradari Detlef Schuppan Hans Scherübl | 2006 | World Journal of Gastroenterology2006，12，32： | 7 |
| 4 | Robust real-time face detection 显示文摘 | Viola P Jones M | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 5 | Multiple instance boos- ting for object detection显示文摘 | Viola P Platt J Zhang Cha | 2007 | Neural Information Pro- cessing Systems2007，18，1： | 1 |
| 6 | HCV core immunodominant region analysis using mouse monoclonal antibodies and human sera: characterization of major epitopes useful for antigen detection显示文摘 | Jolivet-Reynaud C Dalbon P Viola F | 1998 | J Med Virol1998，56，4： | 1 |
| 7 | Robust real time face detection 显示文摘 | VIOLA P JONES M J | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 8 | Fast and Robust Classification using Asymmetric AdaBoost and a Detector Cascade 显示文摘 | Viola P Jones M | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，18，3： | 1 |
| 9 | Multi-modal volume registration by maximization of mutual infcrmation显示文摘 | Wells W M Ⅲ Viola P Atsumi H | 1996 | Med Image Anal1996，3，1： | 1 |
| 10 | Robust real-time face detection显示文摘 | Viola P Jones M | 2004 | International Journal of ComputerVision2004，57，2： | 1 |
| 11 | Alignment by maximization of mutual information显示文摘 | P A Viola W M Wells III | 1997 | International Journal of Computer Vision1997，24，2： | 1 |
| 12 | Alignment by maximization of mutual information显示文摘 | VIOLA P WELLS W | 1997 | International Journal of Computer Vision1997，24，2： | 1 |
| 13 | Multi-modal Volume Registration by Maximization of Mutual Information显示文摘 | Well W M Viola P Atsumi H | 1996 | Medical Image Analysis1996，1，1： | 1 |
| 14 | Robust real-time face detection显示文摘 | VIOLA P JONES M J | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 15 | Robust Real-Time Face Detection 显示文摘 | VIOLA P JONES M | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 16 | Robust real-time object detection显示文摘 | VIOLA P JONES M | 2001 | International Journal of Computer Vision2001，4，： | 1 |
| 17 | Alighment by maximization of mutual information显示文摘 | Viola P William M Wells Ⅲ | 1997 | International Journal of Computer Vision Computer Vision1997，24，2： | 1 |
| 18 | Robust real-time face detection显示文摘 | Viola P Michael J | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 19 | Robust real-time face detection 显示文摘 | Viola P Jones M | 2004 | Int Journal of Computer Vision2004，57，2： | 1 |
| 20 | Robust Real-Time Face Detection显示文摘 | Viola P Jones M | 2004 | Inter- national Journal of Computer Vision2004，57，2： | 1 |
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