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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 4 | Neutron Irradiation Effects on Optical Absorption of KU1 and KS-4V Quartz Glasses and Infrasi1301显示文摘 | Leon M Marti n P Vila R | 2009 | Fusion Engineering and Design2009，84，71819110111： | 1 |
| 5 | Sevoflurane in airway management using fibrobronchoscopy:apropos of 2 difficult orotracheal intubation cases显示文摘 | FERRA M VILA P ESCUDERO A | 1999 | Rev Esp Anestesiol Reanim1999，46，6： | 1 |
| 6 | Design of biodegradable particles for protein delivery显示文摘 | Vila A Sánchez A Tobio M | 2002 | J Control Release2002，78，： | 1 |
| 7 | Increased glyceraldehyde-3-phosphate dehydrogenase expression in renal cell carcinoma identified by RNA-based,arbitrarily primed polymerase chain reaction显示文摘 | Vila M R Nicolas A Morote J | 2000 | Cancer2000，89，1： | 1 |
| 8 | Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cell:Relationship with electronegative LDL显示文摘 | Benitez S Camacho M Arcelus R Vila L Bancell C Ordonez-Llanos J | 2004 | Atherosclerosis2004，177，2： | 1 |
| 9 | Relationship of age-related myocardial infarction risk and Gln/Arg 192 variants of the human paraoxonasel gene:the REGICOR study显示文摘 | SENTI M TOMAS M VILA J | 2001 | Atherosclerosis2001，156，： | 1 |
| 10 | Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus :efficacy and risk of ftmgal over - infection显示文摘 | Gonzalez - Garcia A Diniz - Freitas M Gandara - Vila P | 2006 | Oral Dis2006，12，6： | 1 |
| 11 | Impairment of hepatic stat-3 activation and reduction of PPAR alpha activity in fructose-fed rats显示文摘 | Roglans N Vila L Farre M | 2007 | Hepatology2007，45，： | 1 |
| 12 | Land-use and socio-economic correlates of plant invasions in European and North African countries显示文摘 | Vila M Pujadas J | 2001 | Biological Conservation2001，100，： | 1 |
| 13 | Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population显示文摘 | G6mez M Vila J Elosua R | 2014 | Atherosclerosis2014，232，1： | 1 |
| 14 | Equilibrium constants for methyl tert-butyl ether liquid-phase synthesis显示文摘 | Izquierdo J F Cunill F Vila M | 1992 | Chem Eng Data1992，37，3： | 1 |
| 15 | On aggregation operations of linguistic label显示文摘 | Delgado M Verdegay J L Vila M A | 1993 | International Journal of Intelligent Systems1993，8，： | 1 |
| 16 | The role of PEG on the stability in digestive fluids and in vivo fate of PLA-PEG nanopartieles following oral administration 显示文摘 | Tobio M Sanchez A Vila A | 2000 | Colloids Surfaces B: Biointerfaces2000，18，： | 1 |
| 17 | Design of biodegradable particles for protein delivery显示文摘 | Vila A Sanchez A Tobio M | 2000 | Control Rel2000，78，： | 1 |
| 18 | Linguistic decision making models显示文摘 | Delgado M Verdegay J L Vila M A | 1992 | International Journal of Intelligent Systems1992，7，5： | 1 |
| 19 | A general model forfuzzy linear programming显示文摘 | M Delgado J L Verdegay M A Vila | 1989 | Fuzzy Sets and Systems1989，29，： | 1 |
| 20 | Mitochondria and programmed ceil death in Parkinson' s disease: apoptosis and beyond显示文摘 | Perier C Bove J Vila M | 2012 | Antioxid Redox Signal2012，16，9： | 1 |
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