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| 1 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 2 | Cultivation-Independent Analysis of the Development of the Lactobacillus spp.Community in the Intestinal Tract of Newborn Piglets显示文摘Molecular diversity and development of the Lactobacillus community in the intestinal tract, as influenced by age and intestinal compartment, were studied in one litter of 12 conventionally raised piglets. Piglets were euthanized at each week (3 animals per time). Digesta and tissue samples from stomach, duodenum, jejunum, ileum, caecum, colon, and rectum were collected and analysed by using 16S ribosomal RNA-based methods. DGGE (denaturing gradient gel electrophoresis) profiles revealed that the Lactobacillus communities throughout the GI tract from duodenum to rectum showed good stability at same age. This indicates that fecal Lactobacillus communities can effectively represent the intestinal community. Two dominant bands were found in tissue samples of the small intestine, suggesting that the lactobacilli can adhere to the small intestinal wall. The Lactobacillus communities in different GI tract compartments developed over time. A successional change of Lactobacillus communities was observed from birth, through creep feeding to one week after weaning, showing a trend from simple to complex and back to simple. Furthermore, a clone library of Lactobacillus spp. 16S rRNA gene sequences were generated from jejunal and colonic chymes. Six dominant DGGE bands generated from jejunal chymes were matched with sequences that show 94-98% similarity to the bands derived from L. reuteri, L. delbrueckii, and L. crispatus. Seven dominant DGGE bands generated from colon chymes were matched with sequences that show 88-99% similarity to those derived from L. reuteri, L. delbrueckii, L. amylovorus/L. sobrius, and L. acidophilus. Amplicons related to L. reuteri were found in all DGGE fingerprints from jejunal digesta of age of weeks 1, 3, and 4. Amplicons related to L. amylovorus/L. sobrius were present in all DGGE fingerprints from colonic digesta of age of week 1, 3, and 4. Amplicons related to L. delbrueckii were found before weaning, L. crispatus after creep feeding before weaning and L. acidophilus after weaning. This indicates that L. reuteri and L. amylovorus/L. sobrius probably belong to the permanent composition, while L. delbruckii, L. acidophilus, and L. crispatus probably belong to the temporal groups of Lactobacillus communities in the GI tract of piglets. | YAO Wen ZHU Wei-yun Hauke Smidt Martin W A Verstegen | 2011 | Agricultural Sciences in China2011，10，3： | 7 |
| 3 | 多糖和寡糖的体外发酵特性及其对鸡盲肠微生物菌群的影响显示文摘本研究采用体外累积发酵产气法和16SrDNA指纹图谱鉴定技术研究了来自香菇、银耳和黄芪的天然免疫活性多糖(LenE,TreE和AstE)及酵母胞壁甘露寡糖(MOS)对鸡肠道微生物菌群及其发酵特性的影响。结果表明,三种多糖提取物的总糖含量均占干物质的60%以上,而MOS总糖含量在90%以上。多糖和寡糖具有不同的发酵模式;MOS、AstE和LenE三种糖的发酵模式相似,呈一阶段发酵模式;TreE呈两阶段的发酵模式。三种糖中,MOS和AstE发酵速度较TreE快。MOS和AstE在发酵后总VFA产量最高,pH最低;黄芪多糖发酵后产生较多的直链脂肪酸和较低的氨。这些多糖和寡糖提取物影响肠道微生物的活性和组成成分,体现在发酵模式和发酵终产物的显著改变上。以上研究结果表明,来自香菇、银耳和黄芪的天然免疫活性多糖(LenE,TreE和AstE)及酵母胞壁甘露寡糖(MOS)在体外发酵后,均具有显著改变鸡盲肠微生物发酵终产物的含量和盲肠微生物活性的作用。 | 李万坤 郭福存 赵兴绪 Williams B A Kwakkel R P Verstegen M W A | 2007 | 动物营养学报2007，19，3： | 5 |
| 4 | Effects of dietary oligosaccharides on the growth performance feacal characteristics of young growing pigs 显示文摘 | Houdijk J G M: Bosch M W Verstegen H J | 1998 | Animal Feed Science Technology1998，71，： | 2 |
| 5 | Proliferation-and apoptosis-related proteins in intracranial ependymomas:an immunohistochemical analysis显示文摘 | Verstegen M J Leenstra DT Ijlst-Keizers H | 2002 | J Neurooncol2002，56，1： | 2 |
| 6 | The effect of site of starch digestion on performance of broiler chickens显示文摘 | WEURDING R E ENTING H VERSTEGEN M W A | 2003 | Animal Feed Science and Technology2003，110，14： | 1 |
| 7 | Potentialfor reduction of odorous compounds in seine manure through diet modification 显示文摘 | A L K B Kephart M W A Verstegen | 1998 | J Anim Sci (Submitted)1998，，： | 1 |
| 8 | A recombinant Newcastle disease virus with low-level Vprotein expression is immunogenic and lacks pathogenicity for chicken embryos显示文摘 | Mebatsion T Verstegen S de Vaan L T C | 2001 | J Virol2001，75，： | 1 |
| 9 | Potential for reduction of odorous compounds in swine manure through diet modification显示文摘 | Sutton A L Kephart K B Verstegen M W A | 1999 | Journal of Animal Science1999，77，： | 1 |
| 10 | Identifying a land use change cellular automaton by Bayesian data assimilation 显示文摘 | Verstegen J A Karssenberg D Hilst F V D | 2014 | Environmental Modelling & Software2014，53，1： | 1 |
| 11 | Effect of wheat cultivar and enzyme addition to broiler chicken diets on nutrient digestibility,performance,and apparent metabolizable energy content显示文摘 | Gutierrez del Alamo A Verstegen M W Den Hartog L A | 2008 | Poult Sci2008，87，4： | 1 |
| 12 | Effects of dietary oligosaccharides on the growth performance and faecal characteristics of young growing pigs 显示文摘 | Houdijk J G M Bosch M W Verstegen M W A | 1998 | Animal Feed Science and Technology1998，71，： | 1 |
| 13 | Effects of recombinant porcine somatotropin on metabolic rate in growing pigs 显示文摘 | Verstegen M W van der Hel W Brandsma H A | 1991 | Animal Science1991，69，7： | 1 |
| 14 | Influence of dietary factors on nitrogen partitioning and composition in urine and feces of fatting pigs显示文摘 | Canh TT Aamink AJA Verstegen MW | 1997 | Anim Sci1997，75，： | 1 |
| 15 | Effect of processing plant on pork quality显示文摘 | HAMBRECHT E EISSEN J I VERSTEGEN M W A | 2003 | Meat Science2003，64，： | 1 |
| 16 | Digestible lysine requirement of gilts with high genetic potential for lean gain, in relation to the level of energy intake显示文摘 | Bikker P Verstegen M W A Campbell R G | 1994 | J Anita Sci1994，72，： | 1 |
| 17 | The role of the commensal gut microbial community in broiler chickens显示文摘 | Lan Y Verstegen M W A Tamminga S | 2005 | World''s Poultry Science Journal2005，61，1： | 1 |
| 18 | Are extreme returns priced in the stock market? European evidence 显示文摘 | Annaert J Ceuster M D Verstegen K | 2013 | Journal of Banking & Finance2013，37，9： | 1 |
| 19 | Nitrogen balance of pigs as affected by feedstuffscausing different endogenous nitrogen flow at the terminal ileum 显示文摘 | GRALA W VERSTEGEN M W A LEEUWEN P V | 1997 | Livestock Production Science1997，48，： | 1 |
| 20 | Dietary fructooligosaccharides and transgalactooligosaccharides can affect fermentation characteristics in gut contents and portal plasma of growing pigs显示文摘 | Houdijk J G M Verstegen M W A Bosch M W | 2002 | Livestock Production Science2002，73，： | 1 |
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