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| 1 | Isoplot R: A free and open toolbox for geochronology显示文摘This paper reviews the basic principles of radiometric geochronology as implemented in a new software package called Isoplot R, which was designed to be free, flexible and future-proof. Isoplot R is free because it is written in non-proprietary languages(R, Javascript and HTML) and is released under the GPL license. The program is flexible because its graphical user interface(GUI) is separated from the command line functionality, and because its code is completely open for inspection and modification. To increase future-proofness, the software is built on free and platform-independent foundations that adhere to international standards, have existed for several decades, and continue to grow in popularity.Isoplot R currently includes functions for U-Pb, Pb-Pb,40 Ar/39 Ar, Rb-Sr, Sm-Nd, Lu-Hf, Re-Os, U-Th-He,fission track and U-series disequilibrium dating. It implements isochron regression in two and three dimensions, visualises multi-aliquot datasets as cumulative age distributions, kernel density estimates and radial plots, and calculates weighted mean ages using a modified Chauvenet outlier detection criterion that accounts for the analytical uncertainties in heteroscedastic datasets. Overdispersion of geochronological data with respect to these analytical uncertainties can be attributed to either a proportional underestimation of the analytical uncertainties, or to an additive geological scatter term.Isoplot R keeps track of error correlations of the isotopic ratio measurements within aliquots of the same samples. It uses a statistical framework that will allow it to handle error correlations between aliquots in the future. Other ongoing developments include the implementation of alternative user interfaces and the integration of Isoplot R with other data reduction software. | Pieter Vermeesch | 2018 | Geoscience Frontiers2018，9，5： | 56 |
| 2 | Maximum depositional age estimation revisited显示文摘In a recent review published in this journal,Coutts et al.(2019)compared nine different ways to estimate the maximum depositional age(MDA)of siliclastic rocks by means of detrital geochronology.Their results show that among these methods three are positively and six negatively biased.This paper investigates the cause of these biases and proposes a solution to it.A simple toy example shows that it is theoretically impossible for the reviewed methods to find the correct depositional age in even a best case scenario:the MDA estimates drift to ever smaller values with increasing sample size.The issue can be solved using a maximum likelihood model that was originally developed for fission track thermochronology by Galbraith and Laslett(1993).This approach parameterises the MDA estimation problem with a binary mixture of discrete and continuous distributions.The‘Maximum Likelihood Age’(MLA)algorithm converges to a unique MDA value,unlike the ad hoc methods reviewed by Coutts et al.(2019).It successfully recovers the depositional age for the toy example,and produces sensible results for realistic distributions.This is illustrated with an application to a published dataset of 13 sandstone samples that were analysed by both LA-ICPMS and CA-TIMS U–Pb geochronology.The ad hoc algorithms produce unrealistic MDA estimates that are systematically younger for the LA-ICPMS data than for the CA-TIMS data.The MLA algorithm does not suffer from this negative bias.The MLA method is a purely statistical approach to MDA estimation.Like the ad hoc methods,it does not readily accommodate geological complications such as post-depositional Pb-loss,or analytical issues causing erroneously young outliers.The best approach in such complex cases is to re-analyse the youngest grains using more accurate dating techniques.The results of the MLA method are best visualised on radial plots.Both the model and the plots have applications outside detrital geochronology,for example to determine volcanic eruption ages. | Pieter Vermeesch | 2021 | Geoscience Frontiers2021，12，2： | 3 |
| 3 | The causality of de novo copy number variants is overestimated显示文摘 | Vermeesch JR Balikova I Schrander-Stumpel C | | 0，，： | 1 |
| 4 | Ring syndrome caused by ring chromosome 7 without loss d subtelomeric sequences显示文摘 | Vermeesch JR Baten E Fryns JP | 2002 | Clin Genet2002，62，： | 1 |
| 5 | The IL-9 receptor gene,located in the Xq/Yq pseudoautosomal region,has an autosomal origin,escapes X inactivation and is expressed from the Y显示文摘 | Vermeesch JR Petit P Kermouni A | 1997 | Hum Mol Genet1997，6，1： | 1 |
| 6 | Guidelines for molecular karyotyping in constitutional genetic diagnosis 显示文摘 | Vermeesch J R Fiegler H de-Leeuw N | 2007 | Eur J Hum Genet2007，15，11： | 1 |
| 7 | Nucleocapsid protein VP15 is the basic DNA binding protein of white spot syndrome virus of shrimp显示文摘 | Witteveldt J Vermeesch A M Langenhof M | 2005 | Arch Virol2005，150，6： | 1 |
| 8 | Characterization of glypican-5 and chromosomal localization of human GPC5,a new member of the glypican gene family显示文摘 | Veugelers M Vermeesch J Reekmans G | 1997 | J Genomics1997，40，1： | 1 |
| 9 | PPP2R2C,a gene disrupted in autosomal dominant intellectual disability显示文摘 | Backx L Vermeesch J Pijkels E | | 0，，05： | 1 |
| 10 | Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family 显示文摘 | Veugelers M Vermeesch J Reekmans G | 1997 | Genomics1997，40，1： | 1 |
| 11 | Duplication of the Wolf Hirschhorn syndrome critical region causes neurodevelopmental delay显示文摘 | Hannes F Drozniewska M Vermeesch JR | 2010 | Eur J Med Genet2010，53，3： | 1 |
| 12 | Identification of VP19 and VPl5 of white spot syndrome virus (WSSV) and glycosylation status of the WSSV major structural proteins显示文摘 | van Hulten M C Reijns M Vermeesch A M | 2002 | J Gen Virol2002，83，： | 1 |
| 13 | Expression of Escherichia coli branching enzyme in tubers of amylose-free transgenic potato leads to an increased branching degree of the amylopectin显示文摘 | Vermeesch A M de Vries B J Jacobsen E Visser RGF De Vries B J | 1996 | Plant J1996，10，1： | 1 |
| 14 | Corrigendum to “IsoplotR: A free and open toolbox for geochronology” [Geosci. Front. 9 (2018), 1479-1493]显示文摘Whilst writing a detailed manual for the IsoplotR package(which is now available via the built-in documentation),I found two mistakes in the accompanying paper(Vermeesch,2018).Fortunately,neither of these errors was ever incorporated in the actual computer code,so IsoplotR users need not worry about their results. | Pieter Vermeesch | 2021 | Geoscience Frontiers2021，12，5： | 1 |
| 15 | The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y显示文摘 | Vermeesch J R Petit P Kermouni A | 1997 | Hum Mol Genet1997，6，1： | 1 |
| 16 | Molecular karyotyping: Array CGH quality criteria for constitutional genetic diagnosis 显示文摘 | Vermeesch JR Melotte C Froyen G | 2005 | J Histochem Cytochem2005，53，3： | 1 |
| 17 | Molecular katyotyping: array CGH quality criteria for constitutional genetic diagnosis 显示文摘 | Vermeesch JR Melotte C Froyen G | 2005 | J Histochem Cytochem2005，53，3： | 1 |
| 18 | Early myoclonic encephalopathy caused by a disruption of the neuregulin- 1 re-ceptor ErbB4 显示文摘 | Backx L Ceulemans B Vermeesch JR | 2009 | Eur J Hum Genet2009，17，3： | 1 |
| 19 | Guide lines for molecular karytyping in constitutional genetic diagnosis 显示文摘 | Vermeesch JB FieglerH L eeuw N | 2007 | Eur J Hum Genet2007，15，： | 1 |
| 20 | Mosaic Copy Number Variation in Human Neurons显示文摘 | Michael J. McConnell Michael R. Lindberg Kristen J. Brennand Julia C. Piper Thierry Voet Chris Cowing-Zitron Svetlana Shumilina Roger S. Lasken Joris R. Vermeesch Ira M. Hall Fred H. Gage | 2013 | Science . 2013 (6158)2013，，6158： | 1 |
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