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| 1 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 2 | The Role of Vanadia for the Selective Oxidation of Benzyl Alcohol over Heteropolymolybdate Supported on Alumina显示文摘A series of 12-molybdophosphoric acid (MPA) supported on V2O5 dispersed γ-Al2O3 catalysts with different vanadia loadings were prepared by impregnation and characterized by N2 adsorption-desorption, X-ray diffraction, temperature-programmed reduction, in situ laser Raman spectroscopy, UV-Vis diffused reflectance spectroscopy, scanning electron microscopy, and temperature-programmed desorption of NH3 techniques. Their catalytic activities were evaluated for the vapor phase aerobic oxidation of benzyl alcohol. The catalysts exhibited high catalytic activity and the conversion of benzyl alcohol depended on the vanadia content while the catalyst with 15 wt% V2O5 content showed optimum activity. The characterization results suggest the presence of well-dispersed V2O5 and partially disintegrated Keggin ions of MPA on the support. In situ Raman studies showed a reduced Mo(IV) species when the catalysts were calcined at high temperatures. The high oxidation activity of the catalysts is related to the synergistic effect between MPA and V2O5. | Pasupulet Siva Nageswara RAO Kasanneni Tirumala Venkateswara RAO Potharaju S. SAI PRASAD Nakka LINGAIAH | 2011 | 催化学报2011，32，11： | 3 |
| 3 | Acute and subacute oral toxicity evaluation of Tephrosia purpurea extract in rodents显示文摘 | Talib Hussain Sheeba Fareed HH Siddiqui M Vijaykumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Disease2012，，2： | 3 |
| 4 | Hepatoprotective activity of Amaranthus spinosus in experimental animals显示文摘 | Hussain Zeashan G. Amresh Satyawan Singh Chandana Venkateswara Rao | 2008 | Food and Chemical Toxicology2008，，11： | 2 |
| 5 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 6 | Hydrophobic and physical properties of the ambient pressure dried silica aerogels with sodium silicate precursor using various surface modification agents显示文摘 | A. Parvathy Rao A. Venkateswara Rao G.M. Pajonk | 2007 | Applied Surface Science2007，，14： | 2 |
| 7 | Superhydrophobic silica aerogels based on methyltrimethoxysilane precursor显示文摘 | Venkateswara R Kulkarni M M Amalnerkar D P | 2003 | J Non-crystalline Solids2003，330，： | 1 |
| 8 | Hydrophobic and physical properties of the ambient pressure dried silica aerogels with sodium silicate precursor using various surface modification agents 显示文摘 | PARVATHY R A VENKATESWARA R A PAJONK G M | 2007 | Applied Surface Science2007，253，14： | 1 |
| 9 | A method of non - linear viscoelastic analysis of solid propellant grains for pressure load显示文摘 | JANA M K RENGATHAN K VENKATESWARA R G | 1994 | Computers and Structures1994，52，1： | 1 |
| 10 | Post-critical behavior of a tapered cantilever column under the tip-concentrated follower force with small damping 显示文摘 | B Nageswara Rao G Venkateswara Rao | 1992 | Journal of Sound and Vibration1992，154，2： | 1 |
| 11 | Toxicity of azodrin on the morphology and acetylcholinesterase activity of the earthworm Eisenia foetida显示文摘 | Venkateswara R J Kavitha P | 2004 | Environmental Research2004，96，： | 1 |
| 12 | Effect of methyltrimethoxysilane as a co-precursor on the optical properties of silica aerogels显示文摘 | Venkateswara R Pajonk G M | 2001 | J Non-Crystalline Solids2001，285，： | 1 |
| 13 | Hydrophobic and physical properties of the ambient pressure dried silica aerogels with sodium silicate precursor using various surface modification agents显示文摘 | RAO A Parvathy RAO A Venkateswara PAJONK G M | 2007 | Applied Surface Science2007，253，14： | 1 |
| 14 | The effect of nonlinearities on the strain concentration factors in solid propellant grains显示文摘 | JANA M K RENGATHAN K VENKATESWARA R G | 1996 | Computers and Structures1996，58，2： | 1 |
| 15 | Fatigue-crack growth and fracture resistance of a two-phase (γ+α2) TiAl alloy in duplex and lamellar microstructures显示文摘 | VENKATESWARA RAO K T KIM Y W MUHLSTEIN C L | 1995 | Materials Science and Engineering (A)1995，，： | 1 |
| 16 | A method of non-linear viscoelastic analysis of solid propellant grains for pressure load显示文摘 | Jana M K Rengathan K and Venkateswara R G | 1994 | Computers and Structures1994，52，1： | 1 |
| 17 | Agenetic algorithmic approach for optimization of surface roughness prediction model显示文摘 | Suresh P V S Venkateswara R P Deshmukh S G | | 0，，06： | 1 |
| 18 | Effect of methyltrimethoxysilane as a co-precursor on the optical properties of silica aerogels 显示文摘 | Venkateswara Rao A Pajonk G M | 2001 | Journal of NonCrystalline Solids2001，285，13： | 1 |
| 19 | Comments on 'uses of ohydroxybenzoylacetone in the synthesis of some substituted 2-methylchromones,chelating agents,and related materials'显示文摘 | Venkateswara Rao K | | 0，，13： | 1 |
| 20 | Absorption and desorption of organic liquids in elastic superhydrophobic silica aerogels 显示文摘 | Venkateswara R A Hegde N D Hirashima H | 2007 | Journal of Colloid and Interface Science2007，305，1： | 1 |
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