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| 1 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 3 | Biosorption of nickel (Ⅱ) ions on Baker's yeast 显示文摘 | Padmavathy V Vasudevan P Dhingra S C | 2003 | Process Biochemistry2003，38，10： | 1 |
| 4 | Kinetics of biosorption of cadmium on Baker's yeast显示文摘 | Vasudevan P Padmavathy V Dhingra S C | 2003 | Bioresour Technol2003，89，： | 1 |
| 5 | Synthesis of GAP - PB - GAP triblock copolymer and application as modifier in AP/HTPB composite propellant 显示文摘 | Vasudevan V Sundararajan G | 1999 | Propellants Explosives Pyrotechnics1999，24，5： | 1 |
| 6 | Corrosion resistance of zinc electrodeposits in an ultrasonically agitated bath显示文摘 | PRASAD P B S N V AHILA A VASUDEVAN R | 1993 | Journal of materials science letters1993，22，12： | 1 |
| 7 | Cyclic plastic strain response and fracture behavior of 2009 aluminum alloy metal-matrix composite显示文摘 | SRIVATSAN T S MESLET A H VASUDEVAN V K | 2005 | International Journal of Fatigue2005，27，4： | 1 |
| 8 | Biosorption of nickel (Ⅱ) ions on Baker's yeast显示文摘 | Padmavathy V Vasudevan P Dhingra S C | 2003 | Process Biochem2003，38，10： | 1 |
| 9 | Anti-HHV-6 antibodies in normal population and in cancer patients in India显示文摘 | Shanavas KR Kala V Vasudevan DM | 1992 | J Exp Pathol1992，6，12： | 1 |
| 10 | The microstructure of rapidly solidifled and heat-treated Al-8Fe-V-Si alloys 显示文摘 | Vasudevan V K Fraser H L | 1998 | Material Science and Engineering1998，88，： | 1 |
| 11 | Utilization of spent agroresidues from mushroom cultivation for biogas production显示文摘 | BISARIA R VASUDEVAN P BISARIA V S | 1990 | Appl Microbiol Biotcchnol1990，33，： | 1 |
| 12 | 显示文摘 | P Wang G B Viswanathan V K Vasudevan Metall Trans | 1992 | 23A :6901992，23，： | 1 |
| 13 | Biosorption of nickel ( Ⅱ )ions on Baker's yeast 显示文摘 | Padmavathy V Vasudevan P Dhingra S C | 2003 | Process Biochemistry2003，38，10： | 1 |
| 14 | Color and texture descriptors 显示文摘 | Manjunath B S Ohm Jens-Rainer Vasudevan Vinod V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 15 | The synthesis of water-soluble prodrugs analogs of echinocandin B显示文摘 | Rodriguez M J Vasudevan V Jamison J A | 1999 | Bioorg & Med Chem Lett1999，9，13： | 1 |
| 16 | Biosorption of nickel(Ⅱ)ions on Baker's yeast显示文摘 | Padmavathy V Vasudevan P Dhingra S C | 2003 | Process Biochemistry2003，38，10： | 1 |
| 17 | Cognitive maps for mobile robots - An object based approach显示文摘 | Vasudevan S Gachter S Nguyen V T | 2007 | Robotics and Au- tonomous Systems2007，55，5： | 1 |
| 18 | Color and texture descriptors显示文摘 | MANJUNATH B S VASUDEVAN V V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 19 | Color and text descriptors显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | IEEE Circuit and System for Video Technology2001，11，6： | 1 |
| 20 | Color and texture de- scriptors显示文摘 | Manjunath B S Ohm J R Vasudevan V V | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
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