|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 3 | META-R:A software to analyze data from multi-environment plant breeding trials显示文摘META-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java language.The objective of META-R is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice designs.META-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense heritability.These parameters are very important in the selection of top performing genotypes in plant breeding.META-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical significance.The genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated traits.META-R performs multi-environment analyses by using the residual maximum likelihood(REML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability. | Gregorio Alvarado Francisco M.Rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-Rodríguez Marco A.Lopez-Cruz | 2020 | The Crop Journal2020，8，5： | 4 |
| 4 | A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease显示文摘 | C. Fernández-Miranda M. Pérez-Carreras F. Colina G. López-Alonso C. Vargas J.A. Solís-Herruzo | 2007 | Digestive and Liver Disease2007，，3： | 2 |
| 5 | Activating killer cell immunoglobulin-tike receptor genes' association with recurrent miscarriage显示文摘 | Vargas R G Bompeixe E P Franca P P | 2009 | Am J Reprod Immunol2009，62，1： | 1 |
| 6 | An antitumor promoter from Moringa oleifera Lam显示文摘 | Guevara A P Vargas C Sakurai H | 1999 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis1999，440，2： | 1 |
| 7 | A novel viscosity reducer for kraft process black liquors with a high dry solids content显示文摘 | Llamas P Domingu6z T Vargas J M | 2007 | Engineering and Processing2007，46，3： | 1 |
| 8 | Controlof superficial scald on‘d′Anjou’pears byethoxyquin:Effect of ethoxyquin concentration,timeand method of application,and a combined effect withcontrolled atmosphere storage显示文摘 | Chen P M Varga D M Mielke E A | 1990 | Journal of FoodScience1990，55，1： | 1 |
| 9 | T cells from human allergen-induced late asthmatic responses express IL-12receptor beta2subunit mRNA and respond to IL-12in vitro显示文摘 | Varga E M Wachholz P Nouri-Aria K T | 2000 | J Immunol2000，165，5： | 1 |
| 10 | Characterization of a common precursor population for dendritic cells显示文摘 | del Hoyo GM Martin P Vargas HH | 2002 | Nature2002，415，6875： | 1 |
| 11 | Diet and nutrient factors in colorectal cancer risk 显示文摘 | Vargas A J Thompson P A | 2012 | Nutr Clin Pract2012，27，5： | 1 |
| 12 | T cells from human allergen -induced late asthmatic responses express IL - 12 receptor beta 2 subunit mRNA and respond to IL- 12 in vitro显示文摘 | Varga EM Wachholz P Nouri AK | 2000 | J Immunol2000，165，5： | 1 |
| 13 | CFD study of a variable area ratio ejector using R600a and R152a refrigerants显示文摘 | Varga S Lebre P M S Oliveira A C | 2013 | International Journal of Refrigeration2013，36，1： | 1 |
| 14 | Predictive control of a three-phase neutral-point-clamped inverter显示文摘 | Vargas R Cortes P Ammarm U | 2007 | IEEE Transactions on Industrial Electronics2007，54，5： | 1 |
| 15 | Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor surival显示文摘 | Varga M Obrist P Schneeberger S | 2004 | Clini Cancer Res2004，10，9： | 1 |
| 16 | Suppressors of cytokine signalin regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells显示文摘 | HEMANDEZ VARGAS P LOPEZ FRANCO O SANJUAN G | 2005 | J Am Soc Nephrol2005，16，6： | 1 |
| 17 | Outcomes of clinical and surgical assessment of women with pathological nipple discharge显示文摘 | Vargas H I Vargas M P Eldrageely K | 2006 | AmSurg2006，72，2： | 1 |
| 18 | D, et al, Evaluation of bioventing on a gasoline-ethanol contaminated undisturbed residual soil显示文摘 | Osterreicher-Cunha P Vargas E A J Guimariles J H | 2004 | Journal of Hazardous Materials2004，110，13： | 1 |
| 19 | control of a three-phase neutral-point- inverter 显示文摘 | VARGAS Predictive clamped Electronic R CORTES P AMMANN U | 2007 | IEEE Trans on Industrial s2007，54，5： | 1 |
| 20 | Effects of feeding forage soybean silage on milk production, nutrient digestion, and ruminal fermentation of lactating dairy cows显示文摘 | Vargas Bello-Perez E Mustafa AF Seguin P | 2008 | J Dairy Sci2008，91，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员