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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | 土壤中的生物多样性与生态系统功能显示文摘我们回顾了目前关于土壤生物多样性及其在生态系统过程中的作用、对于人类目标的重要性及对胁迫和扰动的恢复能力等的研究进展。现存物种的数量远远大于人们已经描述的数量,即使是对于肉眼可见的分类群也是如此。而且也普遍缺乏在生物地理学上的综合描述。迫切需要在分类学和对新一代系统科学家培训上做更大努力。尤其是应当集中致力于就我们所知。对生态系统功能起关键作用的土壤生物类群方面。为了确定这种类群,需要对土壤生物区系的影响圈(sphere of Influence,SOI),如根的生物区系、有机物质破碎者(shredder)和土壤生物扰动者(bioturbator)加以识别,这些影响圈比如可能通过与植物的相互作用而控制着生态系统的过程。在这些SOI中,我们分析出了土壤有机体的功能类群。最迫切需要研究的问题是将物种按功能类群进行区分,并确定功能类群中的物种冗余。这种迫切性是根据为阐述与集约化农业、森林扰动、环境污染和全球环境变化有关的土壤功能丧失程度的需要而确定的。目前认为最处于危险的土壤生物区系是那些大型动物群的有机物破碎者、土壤生物扰动者、某些专门的细菌(如硝化细菌和固氮菌)以及形成真菌的菌根中贫乏物种的功能类群。在开展这些优先性研究时,需要使用长期的和大尺度的田间试验,以及地理统计学和地理信息系统等现代方法进行试验研究。 | Lijbert Brussaard Val M.Behan-Pelletier David E.Bignell Valerie K.Brown Wim Didden Patrica Folgarait Carlos Fragoso Diana Wall Freckman Vadakattu V.S.R.Gupta Tsutomu Hattori's David L.Hawkworth Carole Klopatek Patric Lavelle David W.Malloch Josef Rusek Bengt Sderstrom James M.Tiedje Ross A.Virginia 闵庆文 | 1997 | 人类环境杂志1997，26，8： | 6 |
| 3 | Incidence and management of ZIv-aflibercept related toxicities in colorectal cancer显示文摘Ziv-afilbercept(Zaltrap, Ziv) is a humanized fusion protein constructed by joining the vascular endothelial growth factor(VEGF) binding portions of human VEGF receptors 1 and 2 to the Fc portion of human immunoglobulin IgG 1. Recently, a randomized, open-label, phase Ⅲ study compared 5-fluorouracil, leucovorin, irinotecan(FOLFIRI)/Ziv with FOLFIRI/placebo in patients who had been previously treated with oxaliplatin based chemotherapy for metastatic colon cancer(mC RC). Patients who had received prior bevacizumab therapy were also eligible. This study showed that the addition of Ziv improved overall survival with median survival time of 13.5 mo vs 12.06 mo in ziv vs placebo arm. Ziv also improved progression free survival from 4.67 mo to 6.9 mo with a response rate of 19.8% in the Ziv/FOLFIRI group vs 11.1% in FOLFIRI alone group. This led to the approval of Ziv in combination with FOLFIRI in metastatic colon cancer patients treated with prior oxaliplatin regimens. The mostcommon side effects were diarrhea, stomatitis, fatigue, hypertension, weight loss, loss of appetite, abdominal pain, and headache. As the use of Ziv has become more widespread in oncology practices, familiarity with the toxicity profile of the drug and the use of practice guidelines for their treatment has become increasing important. This review will address the toxicities noted in trials using Ziv for the treatment of mC RC, and will provide recommendations for toxicity management. | Muhammad Wasif Saif Valerie Relias Kostas Syrigos Krishna S Gunturu | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 4 | Papillary thyroid cancer and inflammatory bowel disease:Is there a relationship?显示文摘AIM:To formally study age of diagnosis of papillary thyroid cancer(PTC) in inflammatory bowel disease(IBD) patients and evaluate the prevalence of PTC in IBD patients compared to a control population.pothesis that patients with IBD are more likely to be diagnosed with PTC than a control population.A retrospective cohort analysis was performed using the University of Pennsylvania Health System's electronic database.Outpatients from 1998-2009 were included in the search,and patients in the cohort were selected based on ICD-9 codes.Inclusion criteria included the diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) and the concurrent diagnosis of thyroid cancer in comparison to a control population.Using these methods 912 patients with CD and 1774 with UC were compared to 1638 diverticulitis and 19 447 asthma controls.Statistics were performed using corrected chisquare analysis.The primary outcome for this study was the diagnosis of PTC.Approval to conduct this study was obtained by the Institutional Review Board at the University of Pennsylvania.RESULTS:The mean age was 47.5 years(range:18-102 years) and 66% patients were female.An analysis of variance model was used to compare the age of PTC diagnosis between the CD,UC,asthma and diverticulitis groups,and a statistically significant difference in age at PTC diagnosis was noted across all groups(F = 6.35,df = 3,P = 0.0006).The age of PTC diagnosis in CD patients was statistically significantly lower than UC,asthma,and diverticulitis patients(average PTC diagnosis age for CD 25,UC 49,asthma 45,diverticulitis 63).After covarying for sex and age in 2009,the difference in age at PTC diagnosis remained statistically significant(F = 4.13,df = 3,P = 0.0089).A total of 86 patients were diagnosed with PTC.Nine patients(0.5%) with UC were diagnosed with PTC.Patients with UC were not shown to be more likely to develop PTC [odds ratio(OR):1.544,95%CI 0.767-3.108] compared to asthma controls.Four patients(0.4%) with CD were diagnosed with PTC.Patients with CD were not shown to be more likely to develop PTC(OR:1.334,95%CI 0.485-3.672) compared to a control population with asthma.Nine patients(0.5%) with a history of diverticulitis were diagnosed with PTC.Patients with diverticulitis were not shown to be more likely to develop PTC(OR:1.673,95%CI 0.831-3.368) compared to asthma controls.Patients with CD or UC were not less likely to develop PTC compared to those with diverticulitis(CD OR:0.80,95%CI 0.25-2.60;UC OR:0.92,95%CI 0.37-2.33).None of the patients used immunosuppressant medications prior to the diagnosis of PTC(azathioprine,6-mercaptopurine,and methotrexate).CONCLUSION:There is a significant difference in age of diagnosis of PTC in patients with CD compared to patients with UC and the control populations studied. | Irene S Sonu Wojciech Blonski Ming Valerie Lin James Lewis Faten Aberra Gary R Lichtenstein | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 5 | Experimen- tal therapeutics, preclinical pharmacology experimental therapeu- tics with a new 10-deazaaminopterin in human mesothelioma: Fur- ther improving efficacy through structural design, pharmacologic modulation at the Level of MRP ATPases, and combined therapy with Platinums显示文摘 | NUSHMIA Z K YUHONG S VALERIE W R | 2001 | Clin Cancer Res2001，7，10： | 1 |
| 6 | Immunostimulation in crustaceans:does it really protect against infection显示文摘 | VALERI J S JANET H B CHRIS HAUTON | 2003 | Fish & Shellfish Immunology2003，，15： | 1 |
| 7 | New target therapies in advanced pancreatic cancer显示文摘 | Cascinu S Verdecchia L Valeri N | 2006 | Ann Oncol2006，17，5： | 1 |
| 8 | Postinfectious glomerulone- phritis in the elderly显示文摘 | Nasr S H Fidler M E Valeri A M | 2011 | J Am Soc Nephrol2011，22，1： | 1 |
| 9 | Hypothermiainduced reversible platelet dysfunction 显示文摘 | Valeri CE Eduard S Siewers RD | 1987 | Ann Thorac Surg1987，205，： | 1 |
| 10 | Lomaivitieins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis 显示文摘 | He H Ding W W Valerie S B | 2001 | J Am Chem Soc2001，123，22： | 1 |
| 11 | Country-of-Origin Effects on Consumers' Attributions and Word-of-Mouth Communications about Services 显示文摘 | Kachat Andrew Wong Valerie S Folkes | 2008 | Advances in Consumer Research2008，35，1： | 1 |
| 12 | Phage display 显示文摘 | GEORGE P S VALERY A P | 1997 | Chem Rev1997，97，： | 1 |
| 13 | Aerobic and Anaerobic Capacities of DifferentAge and Performance Female Fencers 显示文摘 | Anna S Valery S | 2006 | Medsportpress2006，12，2： | 1 |
| 14 | COMT Val158Met gen- otype as a risk factor for problem behaviors in youth显示文摘 | Matthew D Albaugh BA Valerie S | 2010 | J Am Acad Child Adolesc Psychiatry2010，49，8： | 1 |
| 15 | Brocaenols A-C: novel polyketides from a marine-derived Penicillium brocae显示文摘 | TIM S B VALERIE S B MICHAEL G | 2003 | J Org Chem2003，68，： | 1 |
| 16 | Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the P38 mitogen-activated protein kinase family 显示文摘 | Wang Y H Huang S Valerie P S | 1998 | J Biol Chem1998，273，： | 1 |
| 17 | X-ray Diffraction Investigations of Microstructure of Calcium Hydroxide Crystallites in the Interfacial Transition Zone of Concrete显示文摘 | Harutyunyan Valeri S Abovyan Eduward S Monteiro Paulo J M | 2003 | Journal of the American Ceramic Society2003，86，12： | 1 |
| 18 | Internet Us- age by Low- literacy Adults Seeking Health Information: an observational analysis 显示文摘 | Mehret S B Valerie M M Lonelyss C | 2004 | Journal of Medical Internet Re- search2004，6，3： | 1 |
| 19 | Dense deposit disease:clinicopathologic study of 32 pediatric and adult patients显示文摘 | Nasr S H Valeri A M Appel G B | 2009 | Clin J Am Soc Nephrol2009，4，1： | 1 |
| 20 | An efficient synthesis of 3′-azido-3′-deoxythymidine(AZT)显示文摘 | Czernecki S Valery J M | 1991 | Synthesis1991，，： | 1 |
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