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| 1 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 2 | The maximum reservoir capacity of soils for persistent organic pollutants: implications for global cycling 显示文摘 | Valle M D Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 3 | The maximum reservoir capacity of soils for persistent organic pollutants: implication for global cycling 显示文摘 | Dalla Valle M Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 4 | Cyclodextrins and their uses: a review显示文摘 | E M Martin Del Valle | 2004 | Process Biochemistry2004，39，： | 1 |
| 5 | Carboxylamidase activity in the fall armyworm (Lepidoptera:Noctuidae) and other lepidoptera,orthoptera and dictyoptera显示文摘 | YU S J VALLES S M | 1997 | J Econ Entomol1997，90，6： | 1 |
| 6 | Extraction-atomic absorption method for the determination of arsenic,antimony,selenium and tellurium in geologic samples显示文摘 | Togov V G Vall G A Demidova M G | 1995 | Chem Geol1995，124，： | 1 |
| 7 | Dental infections and coronary atherosclerosis 显示文摘 | Mattila K J Valle M S Nieminen M S | 1993 | Athemsclerosis1993，103，2： | 1 |
| 8 | Pop- ulation genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis 显示文摘 | Hazban MH Brimacombe M Bobadilla del Valle M | 2006 | Antimicrob Agents Chemother2006，50，8： | 1 |
| 9 | Bowel dysfunction in patients with motor complete spinal cord injury: clinical, neurological, and pathophysiological associations显示文摘 | Valles M Vidal J Clave P | 2006 | Am J Gastroenterol2006，101，10： | 1 |
| 10 | Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality:the effect of low-dose is less than optimal in patients with vascular disease due to prothrombotic effects of erythrocytes on platelet reactivity显示文摘 | Santos M Aznar J | 1998 | Circulation1998，97，3： | 1 |
| 11 | Mierostructural evolution during large strain hot rolling of an AM60 alloy 显示文摘 | PEREZ - PRADO M T VALLE J A CONTRERAS J M RUANOO A | 2004 | Scripta Mater2004，50，5： | 1 |
| 12 | Partial characterization of banana starches oxidized by different levels of sodium hypoehlorite显示文摘 | Sanchez-Rivera M M Garcla-Suarez F J L Velazquez del Valle M | 2005 | Carbohydrate Poly mers2005，62，1： | 1 |
| 13 | Cytogenetics of six natural and introduced genotypes of Hemarthria altissima (Poiret) Stapf & Hubbard (Gramineae)显示文摘 | Tedesco S B Battistin A Valls J F M | 1998 | Ciencia Rural1998，28，2： | 1 |
| 14 | Cytology and reproductive behavior of diploid, tetraploid and hexaploid germplasm accessions of a wild forage grass Paspalum compressifolium 显示文摘 | Quarin C L Pozzobon M T Valls J F M | 1996 | Euphytica1996，90，： | 1 |
| 15 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 16 | Cinacalcet reduces the set point of the PTH calcium curve显示文摘 | Valle C Rodriguez M Santamaria R | 2008 | J Am Soc Nephrol2008，19，： | 1 |
| 17 | The relationship between homocysteine and genes of folate-related enzymes in migraine patients显示文摘 | Oterino A Toriello M Valle N | 2010 | Headache2010，50，1： | 1 |
| 18 | Storage and recall capabilities of fuzzy morphological associative memories with adjunction-based learning显示文摘 | Valle M E Sussner P | 2011 | Neural Network2011，24，1： | 1 |
| 19 | Resistance switching in HfO2 metal-insulator-metal devices显示文摘 | Gonon P Mougenot M Vallée C | 2010 | J Appl Phys2010，107，07： | 1 |
| 20 | Chitosan as a potential natural compound to control pre and post - harvest diseases of horticultural commodities显示文摘 | Bautista - Banos S Hemandez - Lauzardo A N Velazquez - del Valle M G | 2006 | Crop Pro- tection2006，25，2： | 1 |
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