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| 1 | Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral recurrence after LT. | Maria J Citores Jose L Lucena Sara de la Fuente Valentin Cuervas-Mons | 2019 | World Journal of Hepatology2019，11，1： | 12 |
| 2 | Role of oxygen and ammonium ions in silver leaching with thiosulfate–ammonia–cupric ions显示文摘The dissolution of silver with thiosulfate and copper ions was studied in a batch-stirred reactor at 25 °C in the absence and presence of various ammonium ions and oxygen concentrations in the aqueous solution. Leaching silver with 4 mg L-1oxygen in the aqueous solution requires high concentration of ammonium and thiosulfate ions. High silver dissolution is achieved at pH of high cupric tetraamine concentration, around pH 9.8, but a high degradation of thiosulfate ions is resulted from their oxidation by the presence of oxygen. When the oxygen concentration is below 1 mg L-1, dissolved silver thiosulfate species are fairly stable and the degradation of thiosulfate ions in the aqueous solution is low. Under these conditions,high silver dissolution is attained using low thiosulfate concentration. At the oxygen concentration of 4 mg L-1,dissolved silver thiosulfate species precipitate out of the aqueous solution significantly affecting silver dissolution.Precipitation of dissolved silver thiosulfate species occurs because of oxidation of the thiosulfate bonding to the silver. | Valentin Ibarra-Galvan Alejandro López-Valdivieso Xiong Tong Yi-Qi Cui | 2014 | Rare Metals2014，33，2： | 3 |
| 3 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 4 | Magnetic resonance imaging changes in Fabry disease 显示文摘 | Ginsberg L Manara R Valentine AR | 2006 | Acta Paediatr Supp12006，95，451： | 1 |
| 5 | Residents' Perceptions of Community Tourism Impacts 显示文摘 | ANDERECK K L VALENTINE K M KNOPF R C | 2005 | Annals of Tourism Research2005，32，4： | 1 |
| 6 | Transvaginal doppler examination of uteri with myomas显示文摘 | Valentin L Marsal K | 1996 | J Clin Ultrasound1996，24，3： | 1 |
| 7 | The specific diversity indices for analysing phytoplankton succession: application to the Cabo Frio (RJ, Brazil)upwelling ecosystem显示文摘 | VALENTIN J L MACEDO - SAIDAH F E TENENBAUM D R | 1991 | Neritica1991，6，： | 1 |
| 8 | A kinetic model of N-nitrosodimethylamine(NDMA) formation during water chlorination /chloramination显示文摘 | Choi J Valentine R L | 2002 | Water Science and Technology2002，46，3： | 1 |
| 9 | Improving strate- gies for diagnosing ovarian cancer:a summary of the In- ternational Ovarian Tumor Analysis (IOTA)studies 显示文摘 | Kaijser J Bourne T Valentin L | 2013 | Ultrasound Obstct Gynecol2013，41，1： | 1 |
| 10 | Clinical importance of appearance of cesarean hysterotomy scar at transvaginal ultrasonography in nonpregnant women显示文摘 | Vikhareva Osser O Valentin L | 2011 | Obstet Gynecol2011，117，3： | 1 |
| 11 | Highresolution three- dimensional micro - computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis 显示文摘 | Barou O Valentin D Vico L | 2002 | Invest Radiol2002，37，1： | 1 |
| 12 | High prevalence of de fects in Cesarean section scars at transvaginal ultrasound ex amination显示文摘 | Osser OV Jokubkiene L Valentin L | 2009 | Ultrasound Obstet Gynecol2009，34，1： | 1 |
| 13 | Modeling the formation of N- nitrosodimethylamine (NDMA) from the reaction of natural organic matter (NOM) with monochloramine 显示文摘 | Chen Z Valentine R L | 2006 | Environ Sci Technol2006，40，23： | 1 |
| 14 | Carbon monoxide poisoning:risk factors for cognitive sequelae and the role of hyperbaric oxygen显示文摘 | Weaver L K Valentine K J Hopkins R O | | 0，，05： | 1 |
| 15 | Natural rubber/clay nanocomposites: Influence of poly(ethylene glycol) on the silicate dispersion and local chain order of rubber network显示文摘 | Carretero-Gonzalez J Valentin J L Arroyo M | 2008 | European Polymer Journal2008，44，11： | 1 |
| 16 | Femtosecond Yb:YCOB laser pumped by narrow-stripe diode and passively mode locked using ion implanted saturable-absorber mirror 显示文摘 | VALENTINE G J KEMP A J B1RK1N D J L | 2000 | Electron Left2000，36，19： | 1 |
| 17 | Isotopic evidence for the incorporation of methane-derived carbon intoforaminifera from modern methane seeps, Hydrate Ridge, Northeast Paeific 显示文摘 | Hill T M Kenett J P Valentine D L | 2004 | Geochimica et Cosmochimica Acta2004，68，22： | 1 |
| 18 | Gray-scale ultrasound morphology in the presence or absence of intrauterine fluid and vascularity as assessed by color Doppler for discrimination between benign and malignant endometrium in women with postmenopausal bleeding 显示文摘 | Epstein E Valentin L | 2006 | Ultrasound Obstet Gynecol2006，28，1： | 1 |
| 19 | High prevalence of defects in Cesarean section scars at transvaginal ultrasound ex- amination显示文摘 | Vikharevaosser O Jokubkiene L Valentin L | 2009 | Ultrasound Obstet Gynecol2009，34，： | 1 |
| 20 | High prevalence of defects in caesarean section scars at transvaginal ultrasound examination 显示文摘 | Osser OV Jokubkiene L Valentin L | 2009 | Ultrasound Obstet Gynecol2009，34，： | 1 |
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