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| 1 | Bax protein may influence the invasion of colorectal cancer显示文摘AIM: To evaluate the expression of Bcl-xL, Bak, and Bax proteins in correlation with particular clinico-histopathological parameters, including tumor invasion front, in patients with colorectal cancer. METHODS: The expression of these proteins was evaluated with the use of the immunohistochemical method in 50 primary tumors. RESULTS: According to observations, a low expression of Bax and Bak proteins is related to the localization of the tumor in the rectum(P < 0.05 and P < 0.05 respectively), which may explain an increased incidence of colorectal cancer in this area. A positive expression of Bax protein also correlates with the presence of cancer cell infiltration to lymph and blood vessels(P < 0.05), which may suggest the participation of this protein in the early stages of colorectal cancer progression. Moreover, a positive expression of Bcl-xL protein correlated with a positive expression of Bak protein. This may suggest a greater participation of Bcl-xL protein in the inhibition of the proapoptotic Bak protein, but not the Bax protein. CONCLUSION: Bax protein is probably very significant in the cancerogenesis mechanism in the large intestine. | Anna Pryczynicz Mariusz Gryko Katarzyna Niewiarowska Dariusz Cepowicz Marek Ustymowicz Andrzej Kemona Katarzyna Guzińska-Ustymowicz | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 2 | Immunohisto-chemical diagnosis of gastrointestinal stromal tumors - an analysisof 80 cases from 2004 to 2010显示文摘 | Kisluk J Gryko M Guzifiska - Ustymowicz K | 2013 | Adv Clin Exp Med2013，22，1： | 1 |
| 3 | MCM - 2, Ki67 and PCNA protein expressions in p33G2 colorectal cancer indicated lymph node involvement显示文摘 | Guzinska - Ustymowicz K Stepien E Kemona A | 2008 | Anticancer Res2008，28，1： | 1 |
| 4 | Evaluation of proliferating markers Ki - 67, PCNA in gastric cancers 显示文摘 | Czyzewska J Guzifiska - Ustymowicz K Lebelt A | 2004 | Rocz Akad Med Bialymst2004，49，1： | 1 |
| 5 | Assessment of blood flow in the ocular circulation in type 2 diabetes patients with Color Doppler imaging显示文摘 | Krasnicki P Mariak Z Ustymowicz A | 2006 | Klin Oczna2006，108，79： | 1 |
| 6 | Immunohistochemical diagnosis of gastrointestinal stromal tumors - an analysis of 80 cases from 2004 to 2010 显示文摘 | KISLUK J GRYKO M GUZINSKA - USTYMOWICZ K | 2013 | Adv Clin Exp Med2013，22，1： | 1 |
| 7 | Expres- sion of the E - cadherin - cateninin patients with pan- creatic ductal adenocarcinoma 显示文摘 | Pryczynicz A Guzinska - Ustymowicz K Kemona A | 2010 | Folia Histochem Cytobiol2010，48，1： | 1 |
| 8 | The role of vascular factors in the development of traumatic optic neuropathy in course of closed head injury显示文摘 | Obucborwska I Ustymowicz A | 2002 | Klin Oczna2002，104，56： | 1 |
| 9 | The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis显示文摘 | Czyzewska J Guzinska-Ustymowicz K Ustymowicz M | 2010 | Folia Histochem Cytobiol2010，1，48： | 1 |
| 10 | Expression of Ki - 67 and PC- NA as proliferating markers in prostate cancer显示文摘 | Sulik M Guzinska - Ustymowicz K | 2002 | Rocz Akad Med Bialymst2002，47，： | 1 |
| 11 | Immunohisto- chemical evaluation of Ki - 67, PCNA and MCM2 proteins pro- liferation index (PI) in advanced gastric cancer显示文摘 | Czyzcwska J Guzifiska - Ustymowicz K | 2009 | Folia His-tochem Cytobiol2009，47，2： | 1 |
| 12 | Assessment of blood flow in the ocular circulation in type 2 diabetes patients with color doppler imaging显示文摘 | Krasnicki P Mariak Z Ustymowicz A | 2006 | Klin Oczna2006，108，79： | 1 |
| 13 | The expression of E- cadherin- catenin complex in patients with advanced gastric cancer: role in formation of metastasis显示文摘 | CzyzewskaJ Cuziriska- Ustymowicz K Ustymowicz M | 2010 | Folia Histochem Cytobiol2010，48，1： | 1 |
| 14 | Evaluation of proliferating markers IG -67, PCNA in gastric cancers显示文摘 | Czyzewska J Guzinska - Ustymowicz K Lebeh A | 2004 | Rocz Akad Med Bialymst2004，49，1： | 1 |
| 15 | Expression of matrix metaUoproteinase - 9 in pancreatic ductal carcinoma is associated with tumormetastasis formation 显示文摘 | Pryczynicz A Guzihska Ustymowicz K Dymicka Piekarska V | 2007 | Folia Histochem Cytobio2007，45，1： | 1 |
| 16 | The expres-sion of E-cadherin-catenin complex in patient with advanced gastriccancer:role in formation of metastasis显示文摘 | Czyzewska J Guzinska- Ustymowicz K Ustymowicz M | 2010 | Folia Histochem Cytobiol2010，480，： | 1 |
| 17 | Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation显示文摘 | Pryczynicz A Guzinska Ustymowicz K Dymicka Piekarska V | 2007 | Folia Histochem Cytobiol2007，45，1： | 1 |
| 18 | Activity of cathepsin B and D in colorectal cancer: relationships with turnout budding 显示文摘 | Guzifiska Ustymowicz K Zalewski B Kasacka I | 2004 | Anticancer Res2004，24，5： | 1 |
| 19 | PTP4A3 (PRL- 3 ) expression correlate with lymphatic metastases in gastric cancer显示文摘 | Pryczynicz A Guzihska - Ustymowicz K Chang XJ | 2010 | Folia Histochem Cytobiol2010，48，4： | 1 |
| 20 | Expression of the E- cadherin - catenin complex in patients with pancreatic ductal adenocarcinoma显示文摘 | Pryczynicz A Guzifiska- Ustymowicz K Kemona A | 2010 | Folia Histochem Cytobiol2010，48，1： | 1 |
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