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| 1 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 2 | Oscillation of Solutions of Nonlinear Partial Differential Equations of Neutral Type | Yu Yuanhong Liu Bin Liu Zhengrong Institute of Applied Mathematics, Academia Sinica, Beijing 100080, China Department of Mathematics, Hubei Normal College, Huangshi 435002. China Department of Mathematics, Yunnan University. Kunming 650091. China Institute of Applied Mathematics of Yunnan Province, Kunming 650091, China | 1997 | Acta Mathematica Sinica,English Series1997，13，4： | 39 |
| 3 | The Constrained Solutions of Two Matrix Equations | An Ping LIAO Zhong Zhi BAI Department of Mathematics. Hunan University. Changshu, 410082. P. R. China Department of Mathematics and Information Science, Changsha University, Changsha 410003. P. R. China Academy of Mathematics and System. Sciences. Chinese Academy of Sciences. Beijing 100080. P. R. China State Key Laboratory of Scientific/Engineering Computing. Chinese Academy of Sciences. Institute of Computational Mathematics and Scientific/Engineering Computing. Academy of Mathematics and System Sciences. Chinese Academy of Sciences. P. O. Box 2719. Beijing 100080. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，4： | 40 |
| 4 | Problems in Homoclinic Bifurcation with Higher Dimensions | Zhu Deming Department of Mathematics, East China Normal University. Shanghai 200062. China | 1998 | Acta Mathematica Sinica,English Series1998，14，3： | 30 |
| 5 | Central Limit Theorems for Asymptotically Negatively Associated Random Fields | Lixin Zhang Department of Mathematics, Zhejiang University. Xixi Campus. Hangzhou 310028. P. R. China | 2000 | Acta Mathematica Sinica,English Series2000，16，4： | 25 |
| 6 | On the Hyper-Order of Solutions of Some Second-Order Linear Differential Equations | CHEN Zong Xuan Department of Mathematics. Jiangxi Normal University. Nanchang 330027. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 24 |
| 7 | Multipliers on Dirichlet Type Spaces | Peng Yan HU Department of Mathematics. Normal College of Shenzhen University. Shenzhen. Guangdong 518060. P. R. China Ji Huai SHI Department of Mathematics. University of Science and Technology of China. Hefei. Anhui 230026, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，2： | 23 |
| 8 | Preparation and activity of conjugate of monoclonal antibody HAb18 against hepatoma F( ab′ )_2 fragment and staphylococcal enterotoxin A显示文摘AIM To prepare the conjugate of staphylococcal enterotoxin A (SEA) protein which is a bacterial SAg and the F(ab')2 fragment of mAb HAbl8 against human hepatocellular carcinoma (HCC), and identify its activity in order to use SAg in the targeting therapy of HCC.METHODS MAb HAbl8 was extracted from the abdominal dropsy of Balb/ c mice, and was purified through chromatography column SP-40HR with Fast protein liquid chromatography (FPLC) system. The F(ab')2 fragment of mAb HAb18 was prepared by papainic digestion method. The conjugate of mAb HAb18 F(ab')2fragment and SEA was prepared with chemical conjugating reagent N-succinimidyl-3-( 2-pyridyldithio) propionate (SPDP) and purified through chromatography column Superose 12with FPLC system. The molecular mass and purity of each collected peak were identified with SDS-PAGE assay. The protein content was assayed by Lowry's method. The antibody activity of HAb18 F (ab')2 against HCC in the conjugate was identified by indirect immunocytochemical ABC method, and the activity of SEA in the conjugate to activate peripheral blood mononuclear cells (PBMC) was identified with MTT assay.RESULTS The lgG mAb HAb18 was extracted,and purified successfully. Immunocytochemical staining demonstrated that it reacted with most of HHCC cells of human HCC cell line. There were two peaks in the process of purification of the prepared HAb18 F(ab)2-SEA conjugate. SDS-PAGE assay demonstrated that the molecular mass of the first peak was about 130 ku, and the second peak was the mixture of about 45 ku and a little 100 ku proteins. The immunocytochemical staining was similar in HAb18 F (ab ')2-SEAconjugate and HAb18 F (ab ')2, i.e., thecytoplasm and/or cell membranes of most HHCC cells were positively stained. The MTT assay showed that the optical absorbance (A) value at 490 nm of HAb18 F (ab')2-SEA conjugate was 0.182 ± 0.012, that of negative control was 0.033± 0.009, and there was significant difference between them ( P < 0.05).CONCLUSION SPDP is a good proteinconjugating reagent and can be used in preparing protein conjugate. The conjugate of mAb HAb18F(ab')2 fragment and SEA protein was preparedsuccessfully in present study and can be used in the experimental study of HCC targeting therapy with the conjugate of SAg and anti-HCC mAbs or their fragments. | Lian Jun Yang Yan Fang Sui Zhi Nan Chen Department of Pathology, Fourth Military Medical University. Xi’an 710032, Shaanxi Province, China | 2001 | World Journal of Gastroenterology2001，7，2： | 20 |
| 9 | Virulence and potential pathogenicity of coccoid Helicobacter pylori induced by antibiotics显示文摘AIM To explore the virulence and the potential pathogenicity of coccoid Helicobacter pylori (H. pylori) transformed from spiral form by exposure to antibiotic.METHODS Three strains of H. pylori, isolated from gastric biopsy specimens of confirmed peptic ulcer, were converted from spiral into coccoid from by exposure to metronidazole.Both spiral and coccoid form of H. pylori were tested for the urease activity, the adherence to Hep-2 cells and the vacuolating cytotoxicity to Hela cells, and the differences of the protein were analysed by SDS-PAGE and Western blot,The mutation of the genes including ureA, ureB,hpaA; vacA and cagA, related with virulence,was detected by means of PCR and PCR-SSCP.RESULTS In the coccoid H. pylori, the urease activity, the adherence to Hep-2 cells and the vacuolating cytotoxicity to Hela cells alldecreased. In strain F44, the rate and index of adherence reduced from 70.0% ± 5.3% to 33% ±5.1% and from 2.6 ±0.4 to 0.96 ±0.3 (P<0.01),respectively. The invasion of coccoid H. pylori into Hep-2 cell could be seen under electronmicroscope. SDS-PAGE showed that the content of the protein with the molecular weight over Mr74 000 decreased, and the hybriditional signal in band Mr 125 000 weakened, while the band Mr 110000 and Mr63000 strengthened in coccoid H. pylori as shown in Western blot. The results of PCR were all positive, and PCR-SSCP indicated that there may exist the point mutation in gene hpaA or vacA.CONCLUSION The virulence and the proteins with molecular weight over Mr74 000 in coccoid H. pylori decrease, but no deletion exists in amplification fragments from ureA, ureB, hpaA,vacA and cagA genes, suggesting that coccoid H. pylori may have potential pathogenicity. | Fei Fei She1 Dong Hui Su1 Jian Yin Lin2 Lin Ying Zhou3 1Department of Microbiology, Fujian Medical University. Fuzhou 350004, Fujian Province, China2Department of Molecular Medicine, Fujian Medical University, Fuzhou 350004, Fujian Province, China 3Laboratory of Electron Microscope, Fujian Medical University, Fuzhou 350004. Fujian Province. ChinaFei Fei She. graduated from Fujian Medical University as a postgraduate in 1991, now associate professor of microbiology and immunology, specialized in molecular biology of pathogen, having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 10 | Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules显示文摘AIM To study the role of cholecystokinin octapeptide ( CCK-8), β-endorphin ( β-EP), and gastrin in an anorexic infantile rat model and no subsequent regulation of nose peptides by the Yunpi complex prescription ErBao Granule.METHODS We fed infantile rats with special prepared forage. A liquid extract of ErBao Granule was administered to the rats daily for 3weeks, CCK-8, β-EP, and gastrin concentrations in hypothalamus, gastric antrum, and plasma of the rats were measured by radioimmunoassay,and were compared with controls.RESULTS Treatment of rats with ErBao Granule inhibited CCK-8 secretion and increased β-EP and gastrin secretion. CCK-8 concentration in hypothalamus and plasma of model control group increased significantly and correlated negatively with food intake of models.respectively. β-EP concentration in gastric antrum and plasma of model control group decreased significantly and showed a positive correlation with food intake of models,respectively. Hypothalamus concentration of β-EP was similar in models and controls. Gastrin concentration in gastric antrum of models was lower than in the blank control group, and correlated positively to food intake of models.Finally, CCK-8 concentrations in plasma of rats showed a positive correlation with plasma β-EP(r- 0.68, P<0.05).CONCLUSION The increased plasma and hypothalamus concentration of CCK-8,decreased gastric antrum and plasma level of β-EP. and decreased gastric antrum concentration of gastrin are associated significantly with the anorexia of infantile anorexic rat models produced by special forage. ErBao Granule can reverse these changes, which may be the major mechanisms of ErBao Granule simulating feeding. | Yong Ping Du1 Yue Ping Zhang2 Shou Chuan Wang3 Jian Shi1 Shao Hua Wu1,1.Department of Traditional Chinese Medicine. Xijing Hospital, theFourth Military Medical University. Xi an 7101132, Shaanxi Province,China 2.Department of Pediatrics. Xijing Hospital, the Fourth Military MedicalUniversity. Xi’an 710032. Shaanxi Province. China 3.Department of Pediatrics. Nanjing University of Traditional ChineseMedicine, Nanjing71011?l, Jiangsu Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 14 |
| 11 | 上海市9所医院前瞻性胃癌前病变5年随访研究显示文摘对上海市9所医院的2000例胃癌前变化进行胃镜随访研究。随访时间:第一部分从1986年1月~1990年3月;第二部分从1986年1月~1993年6月。随访组每6~12个月定期复查胃镜,对照组不进行主动胃镜检查,以积分法观察癌前变化。结果:第一部分随访组胃癌发生率为1.87%(17/909),其中早期胃癌占70.6%(12/17);对照组胃癌发生率为1.25%(9/721),其中早期胃癌占11.1%(1/9)。随访组病理积分从4.25降至2.95。第二部分仅发现1例早期胃癌(1/261)。本研究提示,加强对胃癌高危人群的胃镜随访是早期发现胃癌的有效方法。 | Wu Yuxin, Jiang Shihu, Yuan Yaozong. Dept.of Medicine,Ruijin Hospital,Shanghai Second Medical University. | 1995 | 中华消化杂志1995，15，5： | 14 |
| 12 | Bifurcations of Rough Heteroclinic Loops with Three Saddle Points | JIN Yin Lai ZHU De Ming Department of Mathematics. Linyi Teachers University. Shandong 276005. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 13 |
| 13 | New Families in the Stable Homotopy of Spheres Revisited | LIN Jin Kun Department of Mathematics. Nankai University. Tianjin 300071. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 12 |
| 14 | Functional Limit Theorems for C-R Increments of k-Dimensional Brownian Motion in Holder Norm | Qicai Wei School fo Economics, Zhejiang University. Hangzhou 310028. P. R. China | 2000 | Acta Mathematica Sinica,English Series2000，16，4： | 9 |
| 15 | Z-Graded Lie Superalgebras with Depth One over Fields of Prime Characteristic | Yong Zheng ZHANG Department of Mathematics. Northeast Normal University. Changchun 130024. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，4： | 9 |
| 16 | 生物反馈治疗高血压临床疗效剖析显示文摘对89例Ⅰ/Ⅱ期高血压病人经一年的生物反馈治疗,发现疗效受多种生物心理社会因素的影响,其中收缩压稍低、高神经质(情绪不稳定)、愤怒分值和焦虑分值较高,以及社会支持程度较高的病人其治疗效果较好。 | Zhang Sufang et al, Depart-ment of Medical Psychology, Beijing Medical University. Beijing 100083 | 1995 | 中国心理卫生杂志1995，9，4： | 8 |
| 17 | Nash Inequalities for Markov Processes in Dimension One | MAO Yong Hua Department of Mathematics. Beijing Normal University. Beijing 100875. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 8 |
| 18 | Decision Support System Based on Set Pair Analysis and Its Application显示文摘The paper has made a comparison among some decision models of G-DSS.Based on Set Pair Analysis,it integrates the advantages and shortcomings of decision models of G-DSS and puts forward SP-DSS.Furthermore,the principle of SP-DSS to make decision as well as its application to diagnose sick systems is expounded,and the program flow chart of SP-DSS is presented. | Zhou Zenan(School of Computer and Information Technology,Beijing Jiaotong University. Beijing 100044 China) | 2007 | 工程科学(英文版)2007，5，3： | 7 |
| 19 | Rapid detection of sepsis complicating acute necrotizing pancreatitis using polymerase chain reaction显示文摘INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis and the therapeutic measuses taken by the clinicians ,the patients can pass through the critical carry stages ,and then the septic complication caused by rtanslocated bacteria, mostly gram-negative microbes from the intestines ensues[1]. | Wei Zhong Zhang1 Tian Quan Han2 Yao Qing Tang2 Sheng Dao Zhang2 1Department of Surgery. Huangyan First Hospital, Huangyan 318020, Zhejiang Province. China 2Department of Surgery. Ruijin Hospital. Shanghai Second Medical University. Shanghai 200025. ChinaDr. Wei Zhong Zhang, graduated from Shanghai Second MedicalUniversity receiving master degree of surgery in 1999 he is devoted to basic and clinical investigation on severe acute pancreatitis and has one paper published. | 2001 | World Journal of Gastroenterology2001，7，2： | 7 |
| 20 | Novel Ruthenium Catalyst (K-Ru/C_(60/70)) for Ammonia Synthesis显示文摘A novel ammonia-synthesis catalyst. potassium-promoted ruthenium supported on fullerene (K-Ru/C60/70 ). was prepared and evaluated, It was found that K-Ru/C60/70 was the most active catalyst for ammonia synthesis at atmospheric pressure and 623 K compared with other support materials such as silica, activated carbon. zeolite, λ-Al2O3 and rare earth metal oxide. | Guang WEI Li Hua WANG Yi Ji LIN Jun YI Hong Bo CHEN Dai Wei LIAO (Department of Chemistry, State Key Lab of Physical Chemistry on Solid Surfaces.Institute of Physical Chemistry, Xiamen University. Xiamen 361003) | 1999 | Chinese Chemical Letters1999，10，5： | 7 |
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