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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | Potash-rich volcanic rocks and lamprophyres in western Shandong Province:^(40)Ar-^(39)Ar dating and source tracing显示文摘Highly precise 40Ar-39Ar dating results demon-strate that the ages of potash-rich volcanic rocks in western Shandong Province are 114.7-124.3 Ma, and that of the lamprophyres is 119.6 Ma. The potash-rich volcanic rocks have relatively high (87Sr/86Sr)i ratios ( 0.708715-0.711418) and distinctly negative εNd values ( -11.47--17.54), and are enriched in radiogenic lead (206Pb/204Pb=17.341-17.622, 207Pb/204Pb=15.525-15.538, 208Pb/204Pb=37.563-37.684). Similarly, the lamprophyres also have quite low εNd values (-11.57 - -19.64). Based on the fact that the Sr, Nd and Pb isotopic compositions of potash-rich volcanic rocks are very consistent with that of the clinopyroxene separates, and by integrating comprehensive analyses of their tectonic settings, and extensive comparisons of the Sr, Nd isotopic composi-tions with that of the related simultaneous rocks, it is con-cluded that the potash-rich volcanic rocks and lamprophyres in western Shandong Province were most possibly derived from the partial melting | QIU Jiansheng, XU Xisheng & LO Ching-HuaState Key Laboratory of Mineral Deposit Research of Nanjing University, Nanjing 210093, China Department of Earth Sciences, Nanjing University, Nanjing 210093, China Department of Geology, Taiwan Unive | 2002 | Chinese Science Bulletin2002，47，2： | 39 |
| 3 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 4 | ASTUDY OF VALENCE OF YTTRIUM IN Y_2O_3 Mo CATHODE显示文摘The valenceofelementyttrium of Y2 O3 Mocathode materialhasbeenstudied by usingther mal weight analysis, X ray diffraction analysis, Scanning electron microscopy and X rayphotoelectronspectrum . It hasbeen provedthatyttrium oxidecan bereduced by molybdenum carbide. Thereaction between powdered Y2 O3 and Mo2 Ccan happen at 1173 , and Y2 O3may bereduced to metallicyttrium . Afterthepowder mixtureof Y2 O3 and Mo2 Cwasheat treated at1873 K, Yttrium existsin two kinds of chemicalstate- yttrium of zero valence and yttrium ofthreevalences. | J.S.Wang1,2) ,M.L.Zhou2) ,J.X.Zhang2) ,Z.R.Nie2) T.Y.Zuo2) and G.J.Zhang2) 1) State Key Laboratory of Materials Chemistry and Applications,Peking University ,Beijing 100871 ,China2) Schoolof Materials Science and Engineering ,Beijing Polytechnic Univers | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，4： | 16 |
| 5 | Ultrasound detection of abdominal lymphadenomegaly in subjects with hepatitis C virus infection and persistently normal transaminases:a predictive index of liver histology severity显示文摘UltrasounddetectionofabdominallymphadenomegalyinsubjectswithhepatitisCvirusinfectionandpersistentlynormaltransaminases:apredi... | Maurizio Soresi, Antonio Carroccio, Giulio Bonfissuto, Vincenzo Agate 1, Carmela Magliarisi, Federico Aragona 1, Massimo Levrero 2, Alberto Notarbartolo and Giuseppe Montalto Cattedra di Medicina Interna, 1Istituto di Anatomia Patologica, Univ | 1998 | World Journal of Gastroenterology1998，4，3： | 15 |
| 6 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 7 | Analysis of genetic effects and correlations for nutrient quality traits of indica rice in different environments | SHI Chunhai and ZHU Jun , Agronomy Dept YANG Xiaoe, XUE Jianming , and YU Yonggui, Dept of Soil Sci and Agri Chem, Zhejiang Agri Univ, Hangzhou 310029, China | 1997 | Chinese Rice Research Newsletter1997，5，1： | 9 |
| 8 | REFINED CONNECTIVITY PROPERTIES OF ABELIAN CAYLEY GRAPHS显示文摘Restricted edge connectivity of a graph G is defined to be the minimum size |U| of a set U of edges such that G-U is disconnected and G-U contains no trivial component K1. The high order edge connectivity Ni, i1, is the number of edge outsets of size i. TO determine all Ni, i 1, for a general graph is NP-hard. In this paper, the authors evaluated the restricted edge connectivity and the high order edge connectivity Ni, 1 i -1, for any connected Abelian Cayley graphs explicitly. | LI QIAOLIANG (Department of Applied Mathematics, Shanghai Jiaotong University, Shanghai 200030, ChinaPresend in Department of Mathematics, Hunan Normal University, Changsha 410082, China.)LI QIAO (Department of Applied Mathematics, Shanghai Jiaotong Univ | 1998 | Chinese Annals of Mathematics,Series B1998，19，4： | 7 |
| 9 | K-ATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured Astrocytes显示文摘Increasing evidence, including from our laboratory, has revealed that opening of ATP sensitive potassium channels(K-ATP channels) plays the neuronal protective roles both in vivo and in vitro. Thus K-ATP channel openers(KCOs) have been proposed as potential neuroprotectants. Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats. Since glutamate transporters(GluTs) of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes, the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes. The results showed that nonselective KCO pinacidil, selective mitochondrial KCO diazoxide, novel, and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake, except for the sarcolemmal KCO P1075. Moreover pinacidil, diazoxide, and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+). These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate. Furthermore, either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species (ROS) and phosphorylation of protein kinases C(PKC). These findings are the first to demonstrate that activation of K-ATP channel, especially mitochondrial K-ATP channel, improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation. Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection. | Sun, X. L. Zeng, X. N. Zhou, F. Dai, C. P. Ding, J. H. Hu, G. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Neuropharmacol Lab,Nanjing 210029,Jiangsu,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 7 |
| 10 | Influence of different inoculation methods on the evaluation of the resistance to rice sheath blight(Rhizoctonia solani Kuhn)显示文摘To establish a standard system for genetic studies on sheath blight resistance. a field test was conducted at the experimental farm of Yangzhou University to compare several procedures for inoculating rice plants with R. | PAN Xuebiao CHEN Zongxiang XU Jingyou TONG Yunhui WANG Zibin PAN Xingyuan Dept of Agro of Agri Coll,Yangzhou Univ,Yangzhou 225009,China | 1998 | Chinese Rice Research Newsletter1998，6，2： | 6 |
| 11 | Effect of specimen thickness on Mode Ⅱ fracture toughness of rock显示文摘Anti symmetric four point bending specimens with different thickness, without and with guiding grooves, were used to conduct Mode Ⅱ fracture test and study the effect of specimen thickness on Mode Ⅱ fracture toughness of rock. Numerical calculations show that the occurrence of Mode Ⅱ fracture in the specimens without guiding grooves (when the inner and outer loading points are moved close to the notch plane) and with guiding grooves is attributed to a favorable stress condition created for Mode Ⅱ fracture, i.e. tensile stress at the notch tip is depressed to be lower than the tensile strength or to be compressive stress, and the ratio of shear stress to tensile stress at notch tip is very high. The measured value of Mode Ⅱ fracture toughness K ⅡC decreases with the increase of the specimen thickness or the net thickness of specimen. This is because a thick specimen promotes a plane strain state and thus results in a relatively small fracture toughness. | RAO Qiu hua 1,SUN Zong qi 1,WANG Gui yao 2,XU Ji cheng 3,ZHANG Jing yi 3 (1.College of Resources, Environment and Civil Engineering, Central South University, Changsha 410083, China 2.River and Sea Department, Changsha Communications Univer | 2001 | Journal of Central South University of Technology2001，8，2： | 5 |
| 12 | Analysis of genotype differences of rice response to low Zn^(2+) activity and some morphological characteristics显示文摘Zinc deficiency is one of the most widespread micro-nutritional disorder for rice. To solve the problem, screening Zn-efficient cuivivars is an available method and understanding genotype difference of Zn efficiency and their morphological and physiological characteristics is important. | WANG Renmin, Dept of Agro YANG Xiao’e and YANG Yuai, Dept of Agri Chemistry, ZheJiang Agri Univ, Hangzhou 310029, China | 1998 | Chinese Rice Research Newsletter1998，6，3： | 5 |
| 13 | The insecticide resistance in stripped stem borer,Chilo suppressalis(Walker)显示文摘The stripped stem borer (SSB), Chilo suppressalis (Walker) is one of the major insect pests of rice in China. Chemical control has been a common practice in SSB management since 1950s. Insecticides used included BHC before 1983;organophosphorus insecticides (methyl-parathion, trichophon, methamidophos, and monocrotophos), and chlordimeform in mid-1970s-1980s; Shachongshuang (dimehypo) and Shachongdan (monousltap) since early 1980s. In recent years, SSB population and its damage to rice increased rapidly and failures on control has been reported. To find out the cause of failure and to put forward the suitable control methods, we studied the resistance of SSB to major insecticides used in China. | CAO Mingzhang SHEN Jinliang LIU Xiaoyu Li Mei Dept of Pesticide Sci,College of Plant Protection,Nanjing Agri Univ,Nanjing 210095,China | 2001 | Chinese Rice Research Newsletter2001，9，1： | 5 |
| 14 | Algorithms for k-fault tolerant power assignments in wireless sensor networks显示文摘This paper addresses fault-tolerant many-to-many routing power assignments in heterogeneous wire-less sensor networks.We introduce the k-fault tolerant power assignments problem with the objective of assigning each sensor node transmission power such that(1) any pairwise sensor node is k-vertex connected and(2) the to-tal power consumption is minimized.We propose three solutions for this problem:two centralized algorithms,a greedy algorithm and an O(√n/ε)-approximation algorithm,and an h-hop distributed and localized algorithm.Related theorems and proofs are presented to prove the correctness of our approaches.Furthermore,simulation and experiment results are presented to verify the efficiency of our approaches. | LIU Li 1,2,LI Lian 1,3 & HU Bin 1,4 1 School of Information Science and Engineering,Lanzhou University,Lanzhou 730000,China 2 LRI,Univ Paris-sud and CNRS,Orsay F-91405,France 3 School of Computer and Information,Hefei University of Technology,Hefei 230009,China 4 Department of Computing,Birmingham City University,Galton Building,Perry Barr,Birmingham B42 2SU,UK | 2010 | Science China(Information Sciences)2010，53，12： | 5 |
| 15 | Studies on the Mechanism of the Direct Synthesis of Styrene form Benzene and Ethylene显示文摘StudiesontheMechanismoftheDirectSynthesisofStyreneformBenzeneandEthyleneZHANGQiang,JINRi-guang(CollegeofMater,Sci,andTech,Bei... | ZHANG Qiang , JIN Ri-guang (College of Mater, Sci, and Tech, Beijing Univ, of Them, Beijing,100029) YANG Jun (Dept. of Phys, Chem, Shenyang Pharmaceutical Univ., Shenyang,110015) | 1997 | Chemical Research in Chinese Universities1997，13，3： | 5 |
| 16 | The Research of the Equation Model on the System-level Fault Diagnosis显示文摘In this paper we propose an equation model of system-level fault diagnoses, and construct corresponding theory and algorithms. People can turn any PMC model on ex-test into an equivalent equation (or a system of equations), and find all consistent fault patterns based on the equation model. We can also find all fault patterns, in which the fault node numbers are less than or equal to t without supposing t-diagnosable. It is not impossible for all graphic models. | Hengnong Xuan1, Dafang Zhang2, Yue Wu3, Minwei He4 (1,4: Dept. of Computer, Wuyi University, Jiangmen, Guangdong, 529020, China (2: Dept. of Computer, Hunan University, Changsha, 410082, China ) (3: Institute of Computer Science and Engineering, Univers | 2000 | 湖南大学学报(自然科学版)2000，27，S2： | 5 |
| 17 | Effect of Grinding Temperatures on the Surface Integrity of a Nickel-based Superalloy显示文摘An experimental study was carried out to investigat e the influence of temperatures on workpiece surface integrity in surface grinding of a cast nickel-based superalloy with alumina abrasive wheels. Temperatur e response at the wheel-workpiece interface was measured using a grindable foil /workpiece thermocouple. Specimens with different grinding temperatures were obt ained through changing grinding conditions including depth of cut, workpiece fee d speed, and coolant supply. Changes in surface roughness, residual stress, meta llographies, ground surface morphology, and micro hardness on the specimens were then analyzed. Bending fatigue tests were separately conducted at room temperat ure and 950oC in an effort to evaluate the influence of temperatures on the serv ice life of the ground specimens. A different burning color was found on the gro und workpiece surfaces when grinding temperatures are over a critical value. Alo ng with the emergence of burning color, roughness of the ground workpiece surfac e increased greatly compared with the surfaces without burning color, which was attributed to the plastically deformed coatings on the workpiece surface with el evated temperatures. Excepting the surface roughness, other items concerning the surface integrity of the ground workpiece were not affected by temperatures pro vided that grinding temperatures are not high enough to cause grinding cracks. B ased on the findings in this study, the grinding of the nickel-based superalloy can be divided into two stages in order to increase production efficiency, in which case the first stage is to reach an high material removal rate without concerning of the presence of burning color, whereas the second stage is to remo ve the plastically deformed coatings in order to decrease surface roughness. | YU Yi-qing 1, XU Xi-peng 1, XU Hong-jun 2 (1. College of Mechanical Engineering and Automation, Huaqiao Univers ity, Quanzhou 362011, China 2. Nanjing University of Aeronautics and Astronau tics, Nanjing 210016, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 5 |
| 18 | Nitrification-denitrification Loss and N2O Emission from Urea Applied to Crop-soil Systems in North China Plain显示文摘Nitrogen losses are not only important for agriculture but environment as well. Field experiments were set up in summer corn field at Fengqiu Agro-Ecological Experimental Station of CAS in North China Plain. The soil was in maize-chao soil. Nitrification-denitrification losses and N2O emission were determined by acetylene-inhibition soil-core incubation method in the soils applied urea. The results showed that urea was fast hydrolyzed and became to nitrate. The soil with non urea released 0.33kg N/ha N2O.However, the soil produced 2.91kg N/ha N2O, about 1.94% of the applied N, when the urea was spread on soil surface. N2O emission reduced to 2.50kg N/ha, about 1.67% of the applied N, when the urea was put in deep soil by digging a hole. The denitrification loss was 1.17kg N/ha in control soil. It increased to 3.00kg N/ha and 2.09kg N/ha, which were 2.00% and 1.39% of the used N, in the soils received urea on surface and sub-surface respectively. It was suggested that nitrification-denitrification was probably not a main way of fertilizer nitrogen loss in this region. | DING Hong, CAI Gui-xin, WANG Yue-si and CHEN De-li( Institute of Soil and Fertilizer , Fujian Academy of Agricultural Sciences , Fuzhou 350013 Institute of Soil Science, CAS, Nanjing 210008 LAPC , Institute of Atmospheric Physics, CAS, Beijing 100029 Institute of Food and Land Resources, Univ Melbourne , PV 3052 , Australia ) | 2002 | Agricultural Sciences in China2002，1，2： | 4 |
| 19 | A PARTITIONING PARALLEL PROCEDURE FOR NUMERICAL SIMULATION OF GAS FLOW IN A CYCLONE SEPARATOR显示文摘Based on the SIMPLE-C algori thm and the non-overlapping Domain Decomposition Method (DDM), in which the Dirichlet-N eumann alternative algorithm is employed, a partitioning parallel procedure was developed to numerically simulate fluid flow in complex 3-D domains. It can well remove the limitation of speed and capacity of personal computer on large-scale numerical simulation of complex 3-D domains. In this paper, the 3-D turbulent swirling gas flow in cyclone separator was simulated. In view of the physica l reality, the computational results are bascally reasonable. | Huang Rong-guo, Huan Bo-wen, Zhang Shu-ping (School of Power and Energy Engineering, Shanghai Jiaotong Univers ity, Shanghai 200240, China) | 2002 | Journal of Hydrodynamics2002，14，1： | 4 |
| 20 | Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose:A potential contribution to Alzheimer's disease processes显示文摘Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstrated that estrogen deprivation and oxidative stress act synergistically to accelerate the progress of Alzheimer's disease. Long-term D-galactose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contribution of astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under this animal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic protein immunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the water maze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactose for 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied with severe dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathological changes of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascular astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier permeability. These findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronal deficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's disease and other neurodegenerative diseases. | Hua, X. D. Lei, M. Ding, H. Han, Q. Y. Hu, G. Xiao, M. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurodegenerat,Nanjing 210029,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 4 |
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