|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | Bone marrow osteogenic stem cells:in vitro cultivation and transplantation in diffusion chambers显示文摘 | Chailakhyan PK Gerasimov UV | 1987 | Cell Tissue Kinet1987，20，： | 1 |
| 3 | Interest of cystatin C in screening diabetic patients for early impairment of renal function显示文摘 | Perlemoine C Beauvieux MC Rigalleau UV | 2003 | Metabolism2003，52，10： | 1 |
| 4 | Bone marrow os- teogenic stem cells: in vitro cultivation and transplantation in diffu- sion chambers显示文摘 | Friedenstein A J Chailakhyan RK Gerasimov UV | 1987 | Cell Tissue Kinet1987，20，3： | 1 |
| 5 | Cloning and characterization of a mammalian proton-coupled metalion transporter显示文摘 | Gunshin H Mackenzie B Berger UV | 1997 | Nature1997，388，： | 1 |
| 6 | Bone marrow Osteogenic Stem Cell s:in vitro cultivation and transplantation in diffusion chambers显示文摘 | Friedenstein AJ Chailakhyan RK Gezsimov UV | 1987 | Cell Tissu e Kinet1987，20，： | 1 |
| 7 | High prevalence of low dietary calcium, high phytate consumption, and vitamin D de- ficiency in healthy south Indians 显示文摘 | Harinarayan CV Ramalakshmi T Prasad UV | 2007 | Am J Clin Nutr2007，85，： | 1 |
| 8 | Cloning and characterization of a mammalian proton-coupled metal-ion transporter显示文摘 | Gunshin H Mackenzie B Berger UV | 1997 | Nature1997，388，6641： | 1 |
| 9 | Bone marrow osteogenic stem cells:in vitro cultivation and transplantation in diffusion chambers显示文摘 | FriedensteinAJ Chailakhyan RK Gerasimov UV | 1987 | Cell Tissue Kinet1987，20，3： | 1 |
| 10 | Bone marrow osteogenic stem cells:in Vitro cultivation and transplantation in diffusion chambers显示文摘 | Friedenstein AJ Chailakhyan RK Gerasimov UV | 1987 | Cell Tissue Kinet1987，20，3： | 1 |
| 11 | Chemiluminescence detection for · OH produced by human neutrophils during the respiratory burst显示文摘 | Wyman MP Tscharner UV Deranlean DA | 1987 | Anal Biochem1987，165，： | 1 |
| 12 | Neurodegenera- tion and aging: role of the second genome显示文摘 | Graeber MB Grasbon-Frodl E Eitzen UV | 1998 | J Neurosci Res1998，52，： | 1 |
| 13 | The postorandial atate and risk of cardiovascular disease显示文摘 | Muni UV Mehling C | 1993 | Asia Pacific J Clin Nutr1993，2，： | 1 |
| 14 | Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers 显示文摘 | Chailakhyan RK Gerasimov UV | 1987 | Cell Tissue Kinet (England)1987，20，3： | 1 |
| 15 | Swiss Caucasion population data for 13 STR loci using AmpFISTR profiler plus and cofiler PCR amplification kits显示文摘 | Gehrig C Hochmeister M Borer UV | 1999 | Forensic Sci1999，44，5： | 1 |
| 16 | Colon carcinoma cells as different mechanisms to escape CD 95-mediated apoptosis显示文摘 | starter J Kittstein W | 1998 | Cancer Res1998，58，： | 1 |
| 17 | Modeling Statistical Dependence of Markov Chains via Copula Models显示文摘 | Abegaz F Naik-Nimbalkar UV | 2008 | Journal of Statistical Planning and Inference2008，138，： | 1 |
| 18 | Murineserum cytokines throughout the estrous cycle pregnan-cy and post-partum period 显示文摘 | Orsi NM Gopichandran N Ekbote UV | 2006 | Animal Reproduction2006，96，： | 1 |
| 19 | Pregnancyafter transfer of embryos which were generated from in-vitro matured oocytes 显示文摘 | Jarondi KA Hollanders JMG Sieck UV | 1997 | Hum Reprod1997，12，4： | 1 |
| 20 | Bone marrow osteogenic stem cells:in vitro cultivation and transplantation in diffusion chambers显示文摘 | Friedenstein AJ Chailakhyan RK Gerasimov UV | 1987 | Cell Tissue Kinet1987，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员