|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms. | Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，11： | 5 |
| 3 | Genome - wide association study shows BCL11A associated with persistent fetal hemoglobin and Amelioration of the phenotype of beta -thalassemia 显示文摘 | Uda M Galanello R Sanna S | 2008 | Proc Natl Acad Sci U S A2008，105，5： | 1 |
| 4 | Combined endovascular treatment for bothintracranial aneurysm and symptomatic vasospasm 显示文摘 | Murayama Y Song JK Uda K | 2003 | Am J Neuroradiol2003，24，1： | 1 |
| 5 | Conversion of the rosin acid fraction of crude tall oil into fuels and chemicals 显示文摘 | ROBERT Coll SIDDHARTH Udas WILLIAM A Jacob | 2001 | Energy & Fuels2001，15，5： | 1 |
| 6 | A monoclonal antibody against COOH-terminal peptide of human liver manganese superoxide dismutase显示文摘 | Noji S Uda T | 1989 | J Biol Chem1989，264，： | 1 |
| 7 | Negligible immunogenicity of ter- minally differentiated cells derived from induced pluripotent or embryonic stem cells显示文摘 | Araki R Uda M Hoki Y | 2013 | Nature2013，494，7435： | 1 |
| 8 | Pharmacologic activities of aged garlic extract in comparison with other garlic preparations显示文摘 | KASUGA S UDA N KYO E | 2001 | J Nutr2001，131，3： | 1 |
| 9 | Early detection of lung cancer with laser-induced fluorescence endoscopy and spect rofluorometry显示文摘 | Kusunoki Y Imamura F Uda H | 2000 | Chest2000，118，6： | 1 |
| 10 | Growth of a 3 langasite crystal with clear faceting 显示文摘 | UDA S BUZANOV O | 2000 | J Cryst Growth2000，211，： | 1 |
| 11 | Endovascular treatment of basilar artery trunk aneurysms with Guglielmi detachable coils: clinical experience with 41 aneurysms in 39 patients 显示文摘 | Uda K Murayama Y Gobin YP | 2001 | J Neurosurg2001，95，4： | 1 |
| 12 | The electronic state of supported Rh catalysts and the selectivity for the hydrogenation of carbon monoxide 显示文摘 | Kawai M Uda M Ichikawa M | 1985 | J Phys Chem1985，89，： | 1 |
| 13 | Development of the quantitative PCR method for candidatus Accumulibacter phosphatis and its application to activated sludge显示文摘 | Toshikazu Fukushima Naoki Uda Motoharu Onuki | 2007 | Journal of Water and Environment Technology2007，5，1： | 1 |
| 14 | Combining magnifying prismatic lenswith wide-angle viewing system toenhance view of peripheral retina during vitreous surgery显示文摘 | Ohtsuki M Inoue M Uda S | 2012 | Retina2012，32，9： | 1 |
| 15 | Study of congruent-melting composition of langasite and its effects on crystal quality 显示文摘 | WANG S HARADA J UDA S | 2000 | J Cryst Growth2000，219，： | 1 |
| 16 | High Concentration Tritium Gas Measurement with Small Volume Ionization Chambers for Fusion Fuel Gas Monitors 显示文摘 | Tatsuhiko UDA Kenji OKUNO Yuji MATSUDA | 1991 | nuclear science and technology1991，28，5： | 1 |
| 17 | IL-6 serum levels and productionis related to an altered immune response in polycystic ovary syndromegirls with insulin resistance 显示文摘 | Fulghesu AM Sanna F Uda S | 2011 | Mediators Inflamm2011，2011，38： | 1 |
| 18 | A Study on a Controller to Suppress Periodic Speed Variation显示文摘 | Kosaka M Uda H Bamba E | 2003 | Journal of Low Frequency Noise Vibration and Active Control2003，22，1： | 1 |
| 19 | The eastward subtropical countercurrent in the western North Pacific Ocean显示文摘 | UDA M HASUNUMA K | 1969 | Journal of Oceanography So- ciety of Japan1969，25，4： | 1 |
| 20 | Genetic diversity of Francisella tularensis subspecies holarctica strains isolated in Japan 显示文摘 | Fujita O Uda A Hotta A | 2008 | Mierobiol Immunol2008，52，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员