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| 1 | Esophagectomy for locally advanced esophageal cancer, followed by chemoradiotherapy and adjuvant chemotherapy显示文摘AIM: To compare the efficacy and toxicity of a three-step combination therapy with post-operative radiation alone for locally advanced esophageal cancer.METHODS: Patients with T3-4 and N0-1 esophageal carcinoma from a number of institutions were non-randomly,prospectively enrolled in the study. All patients underwent single-stage curative en bloc esophagectomy. The patients were then assigned into one of two treatment groups based on treatment consisting of either post-operative concurrent chemoradiotherapy (CCRT) with weekly cisplatin 30 mg/m2 followed by systemic adjuvant chemotherapy (four monthly cycles of cisplatin 20 mg/m2 and 5-fiuorouracil 1 000 mg/m2 for five consecutive days),or, post-operative radiation alone. The radiotherapy dose was 55-60 Gy for all patients. Primary end-point of this study was to assess the per-protocol patients' improvement of overall survival benefit. Secondary end-point was designed to evaluate both the per-protocol and intent-to-treat patients' outcome of survival.RESULTS: A total of 60 patients (n = 30 per group) were enrolled in this study. The two groups were generally comparable for demographic characteristics and hematological and non-hematological toxicities. The CCRT with weekly cisplatin was well tolerated, with significantly better overall survival (30.9 mo vs 20.7 mo; 95% CI,27.5-36.4 vs15.2-26.1) and 3-year survival (70.0% vs 33.7%; P = 0.003). Low histological grade of tumor (P<0.001) was associated with favorable survival in these locally advanced patients.CONCLUSION: For locally advanced esophageal cancer,the combination of esophagectomy, post-operative CCRT with weekly cisplatin and systemic adjuvant chemotherapy is well tolerated and effective. A large-scale, prospective randomized trial of this regimen is in progress. | Hung-Chang Liu Shih-Kai Hung Cham-Jer Huang Chung-Chu Chen Ming-Jen Chen Chun-Chao Chang Cheng-Jeng Tai Chi-Yuan Tzen Li-Hua Lu Yu-Jen Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 25 |
| 2 | Magnesium lithospermate B possesses inhibitory activity on Na^+,K^+-ATPase and neuroprotective effects against ischemic stroke显示文摘瞄准:如果镁 lithospermate B (MLB ) 从 Danshen 提取了,检验,鼠尾草植物 miltiorrhiza 的弄干的根,当为经由一样的分子的机制的这繁体中文植物的 cardiactherapeutic 效果负责的一个活跃部件触发了 bycardiac glycosides,可以行动,例如 ouabain 和异羟基洋地黄毒苷。而且,如果,我们想要测试 MLB 对 ischemic 的 provideneuroprotection 可以是为心脏的 glycosides 观察了摸。方法:在 MLB 和 ouabain 之间的类似 inthe 化学药品结构和分子的配置被分析。Na+ 上的 MLB 和 ouabain 的 Theinhibition 力量,一个商业产品的 K+-ATPase 活动,也, asin 从老鼠大脑和心纸巾净化了膜部分,被检验,对 ischemic 击的 MLB 的 compared.Neuroprotective 效果也用一个外皮的基于 brainslice 的试金模型被评估。结果:商业 Na+ 上的剂量依赖者抑制,为 ouabain 的到那的 K+-ATPaseequivalent 为 MLB 被观察近似由重量的半剂量。ouabain 和 MLB 的 Thisrelative 力量也在 Na+ 上为他们的抑制被观察,从老鼠纸巾净化的 K+-ATPase activityof 血浆膜,尽管这 2 个禁止者有点在这些粗略的摘录展出了 lowercompetence。在 ischemic 沙鼠大脑,与 MLB significantlyreduced 处理以后梗塞尺寸,由 2,3,5-triphenyltetrazolium 氯化物染色设想了, byapproximately 55% 什么时候与控制组相比。结论:这些结果显然 suggestthat Danshen 的心脏的治疗学的效果应该部分至少被归因于 Na+ ,由 MLB 的 K+-ATPase,和那 MLB 的 effectiveinhibition 在 gerbilssubjected 提供 anti-ischemic neuroprotection 给焦点的局部缺血和灌注。 | Jason TC TZEN Tzyy-rong JINN Yi-ching CHEN Feng-yin LI Fu-chou CHENG Li-shian SHI Hank KH SHE Balance CM CHEN Vic HSIEH Mu-lin TU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 25 |
| 3 | Analysis of CD117-negative gastrointestinal stromal tumors显示文摘AIM: To identify the gastrointestinal stromal tumors(GISTs) that are negative for CD117 expression by immunohistochemistry and to characterize their malignant potential.METHODS: A total of 108 primary mesenchymal tumors of the gastrointestinal tract were screened to select CD117-negative tumors, from which KIT(exons 9, 11, 13, and 17)and PDGFRA (exons 10, 12, 14, and 18) were sequenced to identify GISTs. Tumor recurrence and distant metastasis were used as the criteria of malignancy.RESULTS: The result showed that approximately 25%(29/108) of the gastrointestinal mesenchymal tumors were negative for CD117 and approximately 6% (7/108)of the tumors were CD117-negative GISTs. All these CD117-negative tumors had a mutated KITand a wildtype PDGFRA. All CD117-negative GISTs with mutations at codons 557/558 of KIThad mitotic counts >10/50 high power field, and 75% (3/4) of them showed multiple recurrence or distant metastasis.CONCLUSION: CD1 17-negative KITmutated GISTs account for approximately 6% of the gastrointestinal mesenchymal tumors. Tumor recurrence or distant metastasis correlates to both theKITmutations at codons 557/558 and the mitotic counts, but not to the tumor size. | Chin-Yuan Tzen Bey-Liing Mau | 2005 | World Journal of Gastroenterology2005，11，7： | 14 |
| 4 | Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids显示文摘瞄准: 决定 Niuchangchih (Antrodia camphorata ) 的活跃成分为它的反煽动性的效果和相关分子的机制负责。 | Yi-ching CHEN Ya-lin LIU Feng-yin LI Chi-I CHANG Sheng-yang WANG Kuo-yang LEE Shun-lai LI Yi-peng CHEN Tzyy-rong JINN Jason TC TZEN | 2011 | Acta Pharmacologica Sinica2011，32，7： | 11 |
| 5 | Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na^+/K^+- ATPase显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Wei-hung YANG Tzyy-rong JINN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，6： | 10 |
| 6 | Effect of sugar positions in ginsenosides and their inhibitory potency on Na^+/K^+-ATPase activity显示文摘 | Ronald JY CHEN Tse-yu CHUNG Feng-yin LI Nan-hei LIN Jason TC TZEN | 2009 | Acta Pharmacologica Sinica2009，30，1： | 10 |
| 7 | Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors显示文摘心脏的 glycosides 的积极 inotropic 效果在人的心肌层在膜界限 Na+/K+-ATPase 上躺在他们的可逆抑制。包含类似于心脏的 glycosides 的核心结构的像类固醇的混合物在通常使用支持血循环的许多中国药被发现。他们中的一些被表明是 Na+/K+-ATPase 禁止者并且这样为他们经由象心脏的 glycosides 的一样的分子的机制的治疗学的效果通常认为地负责。在另一方面, danshen 的镁 lithospermate B 也被建议由有效地禁止 Na+/K+-ATPase 施加它的心脏的治疗学的效果。理论建模建议氢契约的数字和在在 Na+/K+-ATPase 的有约束力的衣袋附近的各种各样的药和残余的有效成分之间的恐水病的相互作用的力量为这些活跃成分的禁止的力量是关键的。人参皂甙,在人参和 sanqi 的活跃成分,当糖一半仅仅被纳入他们的像类固醇的结构的 C-3 位置时,实质地禁止 Na+/K+-ATPase,等价于在心脏的 glycosides 的糖位置。然而,当糖一半被连接到 C-6 或类固醇原子核的 C-20 位置时,他们的禁止的力量被废除;大概,这些糖附件为人参皂甙的入口导致位的阻碍者进 Na+/K+-ATPase 的有约束力的衣袋。心脏的 glycosides,几像类固醇的混合物,和对 ischemic 击的镁 lithospermate B 的 Neuroprotective 效果是因此在一个外皮的大脑观察到基于片的试金模型,和累积数据支持那在大脑的 Na+/K+-ATPase 的有效禁止者能是为 ischemic 的治疗的潜在的药中风。 | Ronald JY CHEN Tzyy-rong JINN Yi-ching CHEN Tse-yu CHUNG Wei-hung YANG Jason TC TZEN | 2011 | Acta Pharmacologica Sinica2011，32，2： | 8 |
| 8 | Quantitative analysis of plasma HBV DNA for early evaluation of the response to transcatheter arterial embolization for HBV-related hepatocellular carcinoma显示文摘AIM: To assesse changes in plasma HBV DNA after TAE in HBV-related HCC and correlate the levels with the pattern of lipiodol accumulation on CT.METHODS: Between April and June 2001, 14 patients with HBV-associated HCC who underwent TAE for inoperable or recurrent tumor were studied. Levels of plasma HBV DNA were measured by real-time quantitative PCR daily for five consecutive days after TAE. More than twofold elevation of circulating HBV DNA was considered as a definite elevation. Abdominal CT was performed 1-2 mo after TAE for the measurement of lipiodol retention.RESULTS: Circulating HBV DNA in 10 out of 13 patients was elevated after TAE, except for one patient whose plasma HBV DNA was undetectable before and after TAE.In group Ⅰ patients (n = 6), the HBV DNA elevation persisted for more than 2 d, while in group Ⅱ (n = 7), the HBV DNA elevation only appeared for 1 d or did not reach a definite elevation. There were no significant differences in age or tumor size between the two groups. Patients in group Ⅰ had significantly better lipiodol retention (79.31±28.79%)on subsequent abdominal CT than group Ⅱ (18.43± 10.61%)(P = 0.02).CONCLUSION: Patients with durable HBV DNA elevation for more than 2 d correlated with good lipiodol retention measured 1 mo later, while others associated with poor lipiodol retention. Thus, circulating HBV DNA may be an early indicator of the success or failure of TAE. | Ying-Wen Su Yu-Wen Huang Sheng-Hsuan Chen Chin-Yuan Tzen | 2005 | World Journal of Gastroenterology2005，11，39： | 4 |
| 9 | Magnesium lithospermate B extracted from Salvia miltiorrhiza elevats intracellular Ca2+ level in SHSY5Y cells显示文摘 | Yi-ching CHEN Tzyy-rong JINN Tse-yu CHUNG Feng-yin LI Ruey-jane FAN Jason TC TZEN | 2010 | Acta Pharmacologica Sinica2010，31，8： | 4 |
| 10 | Differential diagnosis of Parkinson's disease and vascular parkinsonism by 99mTc-TRODAT-1显示文摘 | Tzen KY Lu CS Yen TC | 2001 | J Nucl Med2001，42，3： | 2 |
| 11 | A simple and effective method to prepare immobilized enzymes using artificial oil bodies显示文摘 | Chiang, C. J. Chen, H. C. Kuo, H. F. Chao, Y. P. Tzen, J. T. C. | 2007 | 中国生物学文摘2007，21，2： | 2 |
| 12 | Characteristics of well-differentiated thyroid cancer associated with multinodular goiter 显示文摘 | Cheng SP Liu CL Tzen CY | 2008 | Langenbecks Arch Surg2008，393，5： | 1 |
| 13 | Differential diagnosis of Parkinson's disease and vascular Parkinsonism by ^99mTc-TRODAT-1 显示文摘 | Tzen K Y Lu C S Yen T C | 2001 | Journal of Nuclear Medicine2001，42，3： | 1 |
| 14 | Spectrum and prognostica- tion of KIT and PDGFRA mutation in gastro intestinal stromal tumors 显示文摘 | Tzen CY Wang MN Mau BL | 2008 | Eur J Surg Oncol2008，34，5： | 1 |
| 15 | Surgical treatment of phyllodes tumors of the breast :ret roapective review of 172 cases 显示文摘 | Chen WH Cheng SP Tzen CY | 2005 | J Surg Oncol2005，91，3： | 1 |
| 16 | Whole-body 18F-FDG PET in recurrent or metastatic nasopharyngeal carcinoma显示文摘 | Yen RF Hong RL Tzen KY | 2005 | J Nucl Med2005，46，5： | 1 |
| 17 | Identification and comparison of phenolic compounds in the preparation of oolong tea manufactured by semifermentation and drying processes显示文摘 | DOU J LEE V S Y TZEN J T C | | 0，，18： | 1 |
| 18 | Surgical treament of phyllodes tumors of the breast: retrospective review of 172 cases 显示文摘 | Chert wn Cheng SP Tzen CY | 2005 | J Surg Oncol2005，91，3： | 1 |
| 19 | Novel Cinobufagin Oxime Ether Derivatives as Potential Na+/K+-ATPase Inhibitors: Synthesis, Biological Screening and Molecular Docking显示文摘 | LIANG Guangping CHUNG Tseyu GUO Jinhua ZHANG Rongrong XU Wei TZEN Jason T.C JIANG Renwang | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 20 | Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases显示文摘 | Chen WH Cheng SP Tzen CY | 2005 | J Surg Oncol2005，91，3： | 1 |
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