|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 2 | Can platelet count/spleen diameter ratio be used for cirrhotic children to predict esophageal varices?显示文摘AIM To determine the laboratory and radiologic parameters, including the platelet count(PC)-to-spleen diameter(SD) ratio as a non-invasive marker that may predict the presence of esophageal varices(EV) in children with cirrhosis.METHODS Eighty-nine patients with cirrhosis, but without a history of variceal bleeding were prospectively included. The children were grouped into 6-12 and 12-18 years of age groups. These groups were also divided into 2 subgroups(presence and absence of EV). All of the patients underwent a complete biochemical and radiologic evaluation. The PC(n/mm^3)-to-SD(mm) ratio was calculated for each patient. RESULTS Sixty-nine of 98(70.4%) patients had EV. The presence of ascites in all age groups was significantly associatedwith the presence of EV. There were no differences in serum albumin levels, PC, SD and the PC-to-SD ratio between the presence and absence of EV groups in both age groups(P > 0.05). CONCLUSION Laboratory and radiologic parameters, including the PC-to-SD ratio as a non-invasive marker(except for the presence of ascites), was inappropriate for detecting EV in children with cirrhosis. | Oya Balci Sezer Deniz Celik Nihal Tutar Figen Ozcay | 2016 | World Journal of Hepatology2016，8，33： | 4 |
| 3 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 4 | Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease显示文摘 | Seyhan EC Ozgul MA Tutar N | 2013 | COPD2013，10，4： | 1 |
| 5 | Large eddy simulation of a smooth circular cylinder oscillating normal to a uniform flow 显示文摘 | Tutar M Holdo A E | 2000 | Journal of Fluids Engineering2000，122，： | 1 |
| 6 | Increase in soluble E-selectin level after PTCA and stent implantation : a potential marker of restenosls显示文摘 | Kilickap M Tutar E Aydintug O | 2004 | lnt J Cardiol2004，93，1： | 1 |
| 7 | Heat shock proteins;an overview显示文摘 | TUTAR L TUTAR Y | 2010 | Curr Pharm Biotechnol2010，11，2： | 1 |
| 8 | The effects of L-carnitine treat- ment on left ventricular function and erythrocyte superoxide dis- mutase activity in patients with ischemic cardiomyopathy显示文摘 | Gtirlek A Tutar E Akqil E | 2000 | EurJ Heart Fail2000，2，2： | 1 |
| 9 | Computational modeling of airflow patterns and heat transfer prediction through products in a vented box during cooling显示文摘 | Tutar M Erdogdu F Toka B | 2009 | International Journal of Refrigeration2009，32，2： | 1 |
| 10 | Autonomic nervous system functions in children with breath-holding spells and effects of iron deficiency 显示文摘 | Kolkiran A Tutar E Atalay S | 2005 | Acta Paediatr2005，94，9： | 1 |
| 11 | Diagnostic tool is in the preoperative e- valuation of children with anomalous pulmonary venous connections 显示文摘 | Ucar T Fitoz S Tutar E | 2008 | Int J Cardiovasc Imaging2008，24，2： | 1 |
| 12 | Incident cases of heart failure in a community cohort: importance and outcomes of patients with preserved systolic function显示文摘 | Maria Ansari Mark Alexander Ali Tutar Barry M Massie | 2003 | American Heart Journal2003，，1： | 1 |
| 13 | Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease显示文摘 | Tutar N Metan G Ko AN | 2013 | Multidiscip Respir Med2013，8，1： | 1 |
| 14 | Therapeutic Targeting of microRNAs in Cancer: Future Perspectives 显示文摘 | Tutar L Tutar E zgiir A | 2015 | Drug Dev Res2015，76，7： | 1 |
| 15 | The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy显示文摘 | Gurlek A Tutar E Akcil E | 2000 | Eur J Heart Fail2000，2，2： | 1 |
| 16 | Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease显示文摘 | Seyhan EQOzguI MA Tutar N | 2013 | COPD2013，10，4： | 1 |
| 17 | Large eddy simulation of wind flow around parallel buildings with varying configurations显示文摘 | Tutar M Oguz G | 2002 | Fluid Dynamics Research2002，31，12： | 1 |
| 18 | Large eddy simulation of wind flow around parallel buildings with varying configurations显示文摘 | TUTAR M and OGUZ G | 2002 | Fluid Dynamics Research2002，31，12： | 1 |
| 19 | Invasive pulmonary as- pergillosis in patients with chronic obstructive pulmonary disease显示文摘 | Tutar N Metan G Ko AN | 2013 | Multidiscip Respir Med2013，8，1： | 1 |
| 20 | Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease显示文摘 | Tutar N Metan G Koc A | 2013 | Multidiscip Respir Med2013，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员