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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Evolution of the Internet AS-level topology:From nodes and edges to components显示文摘Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology might elucidate disciplines governing the dynamic process of complex systems. It may also contribute to a more intelligent communication network framework based on its autonomous behavior. In this paper, the Internet Autonomous Systems(ASes) topology from 1998 to 2013 was studied by deconstructing and analysing topological entities on three different scales(i.e., nodes,edges and 3 network components: single-edge component M1, binary component M2 and triangle component M3). The results indicate that: a) 95% of the Internet edges are internal edges(as opposed to external and boundary edges); b) the Internet network consists mainly of internal components, particularly M2 internal components; c) in most cases, a node initially connects with multiple nodes to form an M2 component to take part in the network; d) the Internet network evolves to lower entropy. Furthermore, we find that, as a complex system, the evolution of the Internet exhibits a behavioral series,which is similar to the biological phenomena concerned with the study on metabolism and replication. To the best of our knowledge, this is the first study of the evolution of the Internet network through analysis of dynamic features of its nodes,edges and components, and therefore our study represents an innovative approach to the subject. | 刘晓 王进法 景薇 Menno de Jong Jeroen S Tummers 赵海 | 2018 | Chinese Physics B2018，27，12： | 2 |
| 3 | Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicatethat epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns显示文摘 | Mark Tummers Irma Thesleff | | 0，，02： | 1 |
| 4 | Root or crown:a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species显示文摘 | Mark Tummers Irma Thesleff | 2003 | Development2003，30，： | 1 |
| 5 | Root or Crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species显示文摘 | Tummers M Thesleff I | 2003 | Development2003，130，6： | 1 |
| 6 | Organization, work and work reactions: a study of the relationship between organizational aspects of nursing and nurses' work characteristics and work reactions显示文摘 | Tummers GE Landeweerd JA van Merode GG | 2002 | Scand J Caring Sci2002，16，1： | 1 |
| 7 | Expresion of bone morphogenetic proteins and Msx genes during root formation 显示文摘 | Yamashiro T Tummers M Theslef | 2003 | J Dent Res2003，82，3： | 1 |
| 8 | Activation of the Notch signaling pathway in response to pulp capping of rat molars 显示文摘 | Lovschall H Tummers M Thesleff I | 2005 | Eur J Oral Sci2005，113，4： | 1 |
| 9 | Leadership and meaningful work in the public sector显示文摘 | TUMMERS L G KNIES E | 2013 | Public Administration Review2013，73，6： | 1 |
| 10 | Clinical sig-nificance of isolated intraperitoneal fluid on computed tomography inpediatric blunt abdominal trauma显示文摘 | Jose G Christiano Michael Tummers | | 0，，06： | 1 |
| 11 | Intraopera- tire guidance in parathyroid surgery using near-infrared flu- orescence imaging and low-dose Methylene Blue显示文摘 | Tummers QR Schepers A Hamming JF et a/ | 2015 | Surgery2015，158，5： | 1 |
| 12 | Aeromonas cav-iae infection mimicking inflammatory bowel disease in a child显示文摘 | Van Der Gaag EJ Roelofsen E Tummers RF | 2005 | Ned Tijdschr Geneeskd2005，149，13： | 1 |
| 13 | Stem cells and tissue engineering:prospects for regenerating tissues in dental practice 显示文摘 | Thesleff I Tummers M | 2003 | Med Princ Pract2003，12，1： | 1 |
| 14 | Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs 显示文摘 | Michon F Tummers M Kyyrfinen M | 2010 | Dev Biol2010，340，2： | 1 |
| 15 | Quantitative Methods in Public Administration:Their Use and Development Through Time 显示文摘 | Groeneveld S Tummers L Bronkhorst B | 2015 | International Public Management Journal2015，18，1： | 1 |
| 16 | Stem Cells and Tissue Engineering:Prospects for regenerating tissues in dental practice 显示文摘 | Thesleff I Tummers M | 2003 | Med Princ Pract2003，12，1： | 1 |
| 17 | Ig- nition kernel formation and lift off behavior of jet in-hot co-flow flames显示文摘 | OLDENHOF E TUMMERS M J VEEN E H | 2010 | Combustion and Flame2010，157，6： | 1 |
| 18 | Real-time near-infrared fluorescence guided surgery in gynecologic oncology: A review of the current state of the art显示文摘 | Handgraaf HM Verbeek FR Tummers QG | 2014 | Gyneeol Oneol2014，135，3： | 1 |
| 19 | Activation of the Notchsignaling pathway in response to pulp capping of rat molars显示文摘 | LФvschall H Tummers M Thesleff I | 2005 | Eur J Oral Sci2005，113，4： | 1 |
| 20 | Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment 显示文摘 | Dijkgraaf EM Heusinkveld M Tummers B | 2013 | Cancer Res2013，73，8： | 1 |
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