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| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 3 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 4 | Effect of Free Radical Scavenger on Space Charge Distribution in Polyethylene during Electrical Aging显示文摘 | Yin Y Xiao D M Tu D M | 2002 | Jpn J Appl Phys2002，41，6： | 2 |
| 5 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 6 | Phycobilin : cystein-84 biliprotein lyase,a near universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins 显示文摘 | Zhao K H Su P Tu J M | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 7 | A fern that hyperaccumulates arsenic显示文摘 | Ma L Q Kenneth M K Tu C | 2001 | Nature2001，409，6820： | 1 |
| 8 | Video object tracking using adaptive Kalman filter显示文摘 | WENG S K KUO C M TU S K | 2006 | Journal of Visual Communication and Image Representation2006，17，6： | 1 |
| 9 | Molecular mechanisms of the LPS-induced non-apoptotic ER Stress-CHOP pathway 显示文摘 | Blattner S M Tu Y Tisherman R | 2010 | J Biochem2010，147，4： | 1 |
| 10 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，5148： | 1 |
| 11 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，： | 1 |
| 12 | Normalization of retinal vascular permeability in experimental diabetes with genistein显示文摘 | Nakajima M Cooney MJ Tu AH | 2001 | Invest Ophthalmol Vis Sci2001，42，9： | 1 |
| 13 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，： | 1 |
| 14 | Physics and materials challenges for lead-free solders 显示文摘 | Tu K N Gusak A M Li M | 2003 | Journal of Applied Physics2003，93，3： | 1 |
| 15 | Locking compression plate and cerclage band for type B1 periprosthetic femoral fractures preliminary results at average 30-month follow-up 显示文摘 | Xue H Tu Y Cai M | 2011 | J Arthroplasty2011，26，3： | 1 |
| 16 | Active carbon-ceramic sphere as sup- port of ruthenium catalysts for catalytic wet air oxidation (CWAO) of resin effluent 显示文摘 | Liu W M Hu Y Q Tu S T | 2010 | J Hazard Mater2010，179，： | 1 |
| 17 | Improvement of HPLC separation of acetic acid and levulinic acid in the profiling of biomass hydrolysate显示文摘 | Xie R Tu M B Wu Y | 2011 | Bioresource Technology2011，102，： | 1 |
| 18 | A fem that hyperaccumulates arsenic显示文摘 | Ma L Q Komar K M Tu C Zhang W H Cai Y Kennelley E D | 2001 | Nature2001，409，： | 1 |
| 19 | Treatment of viable cesarean scar ectopic pregnancy with suction curettage显示文摘 | Arslan M Pata O Dilek TU | 2005 | Int J Gynecol Obstet2005，89，2： | 1 |
| 20 | Assessment of replication of research evidence from animals to humans in studies on peri - im- plantitis therapy 显示文摘 | Jr CMF Schmitter M Tu YK | 2009 | Journal of Dentistry2009，37，10： | 1 |
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