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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Reversible and resistant components of PCB adsorption-desorption: Isotherms 显示文摘 | Horzempa L M | 1982 | Environ Sci Technol1982，16，9： | 1 |
| 3 | Decreased transcription,expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus显示文摘 | Rivas L Zabaleta M Toro F | 2009 | Autoimmunity2009，42，4： | 1 |
| 4 | Proliferation activety and steroid hormone receptor status in male breast carcinoma显示文摘 | Munoz D E Toro M M Maffini M V | 1998 | J Steroid Biochem Mol Boil1998，67，4： | 1 |
| 5 | Heritahility esti- mates of larval and spat shell height in the Chilean blue mussel (Mytilus chilensis Hupe 1854) produced under controlled laborato ry conditions 显示文摘 | Toro J E Alcapan A C Vergara A M | 2004 | Aquae Res2004，35，： | 1 |
| 6 | A pneumatic glove and immersive virtual reality environment for hand rehabilitative tra- ining after stroke 显示文摘 | Connelly L Jia Y Toro ML et M | 2010 | IEEE Trans Neural Syst Rehabil Eng2010，18，5： | 1 |
| 7 | pMdTl,asmall ColEl-like plasmid mobilizing a new variant of the aac(6’)-Ib-cr gene in Salmonella enterica serovar Typhimurium显示文摘 | de Toro M Rodriguez I Rojo-Bezares B | 2013 | J Antimicrob Chemother2013，，： | 1 |
| 8 | Effects of Urbanization on Climate of Istanbul and Ankara 显示文摘 | Karaca M Tayan M Toros H | 1995 | Atmospheric Environment1995，29，23： | 1 |
| 9 | Toxicity of cadmium in sediments: the role of acid volatile sulfide 显示文摘 | Di Toro D M Mahony J D Hansen D J | 1990 | Environmental Toxicology and Chemistry1990，9，12： | 1 |
| 10 | Tide-dominated estuarine facies in the Hollin and Napo Formations, Sacha field,Orlente basin, Ecuador显示文摘 | Shanmugam G Poffenberger M Toro Alava J | 2000 | AAPG2000，84，5： | 1 |
| 11 | Restoration of the contact surface in the HLL Riemann solver显示文摘 | TORO E F SPRUCE M SPEARES W | 1994 | Shock Waves1994，4，1： | 1 |
| 12 | Toxicity of cadmium in sediments: the role of acid volatile sulfide 显示文摘 | DI TORO D M MAHONY J D HANSEN D J | 1990 | Environmental Toxicology and Chemistry1990，9，12： | 1 |
| 13 | Long- term adherence to first-line highly active antiretroviral therapy in a hospital-based cohort: predictors and impact on virologic response and relapse显示文摘 | MANZOLI L PARRUTI G TORO P M | 2006 | AIDS Patient Care STDS2006，20，1： | 1 |
| 14 | Restoration of the contact surface in the HLL-Riemann solver显示文摘 | Toro E F Spruce M Speares W | 1994 | Shock Waves1994，4，： | 1 |
| 15 | Digestive enzymes in juvenile green abalone,Haliotis fulgens, fed natural food显示文摘 | Garcia-Carrefio F L Navarrete del Toro M A Serviere-Zaragoza E | 2003 | Comp Biochem Physiol2003，134，： | 1 |
| 16 | Genetic diversity and se-lection regulates evolution of infectious bronchitis virus显示文摘 | Toro H Santen V L ackwood M W | 2012 | A-vian Dis2012，56，3： | 1 |
| 17 | Practical implementation of optimal management strategies in conservation programmes:A mate selection method显示文摘 | Fernandez J Toro M A Caballero A | 2001 | Animal Biodiversity and Conservation2001，24，2： | 1 |
| 18 | A Dynamic Model of Phytoplankton Population In the sacramento San Joaquin Delta显示文摘 | Di toro D M O'Connor D J Thomann T V | 1971 | Advances in Chemistry American Chemical Society1971，106，： | 1 |
| 19 | Tide dominated estuarine facies in the Hollin and Napo ('T'and'U') Formation (Cretaceous), Sacha field, Oriente basin, Ecuador 显示文摘 | Shanmugam G Poffenberger M Toro Alava J | 2000 | AAPG Bulletin2000，84，5： | 1 |
| 20 | Obsessive-- compulsive disorder in childhood and adolescende: a clinical study显示文摘 | TORO J CERVERA M OSEJO E | 1992 | J Child Psychol Psychiatr1992，33，6： | 1 |
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