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| 1 | Neoadjuvant-intensified treatment for rectal cancer:Time to change?显示文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control. | Daniela Musio Francesca De Felice Nadia Bulzonetti Roberta Guarnaccia Rossella Caiazzo Caterina Bangrazi Nicola Raffetto Vincenzo Tombolini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 2 | Neoadjuvant chemoradiotherapy for locally advanced rectal cancer:The debate continues显示文摘Rectal carcinoma represents the 30% of all colorectal cancers, with about 40000 new cases/years. In the past two decades, the management of rectal cancer has made important progress, highlighting the main role of a multimodality strategy approach, combining surgery, radiation therapy and chemotherapy. Nowadays, surgery remains the primary treatment and neoadjuvant chemoradiotherapy, based on fluoropyrimidine(5-FU) continuous infusion, is considered the standard in locally advanced rectal carcinoma. The aim is to reduce the incidence of local recurrence and to perform a conservative surgery. To improve these purposes different drugs combination have been tested in the neo-adjuvant setting. At American Society of Clinical Oncology 2014 an important abstract was presented focusing on the role of adding oxaliplatin to concomitant treatment, in patients with locally advanced rectal carcinoma. Rodel et al reported on the CAO/ARO/AIO-04 randomized phase Ⅲ trial that compared standard treatment with 5-FU and radiation therapy, to oxaliplatin plus 5-FU inassociation with radiation therapy. The addition of oxaliplatin to the neo-adjuvant treatment has been shown to improve disease-free survival from 71.2% to 75.9%(P = 0.03). This editorial was planned to clarify the optimal treatment in patients with locally advanced rectal cancer, considering the results from CAO/ARO/AIO-04 study. | Francesca De Felice Daniela Musio Luciano Izzo Vincenzo Tombolini | 2014 | World Journal of Gastrointestinal Oncology2014，6，12： | 5 |
| 3 | An unusual case of fatty liver in a patient with desmoid tumor显示文摘A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis. | Francesca De Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini | 2012 | World Journal of Gastroenterology2012，18，24： | 2 |
| 4 | Interaction between gfp-tagged Pseudomonas tolaasii P12 and Pleurotus eryngii 显示文摘 | Russo A Filippi C Tombolini R | 2003 | Microbiol Res2003，158，6： | 1 |
| 5 | Radiontherapy alone in elderly patients with medically inoperable stage ]IIA and IIB non- small cell lung cancer显示文摘 | Tombolini V Bonanni A Donato V | 2000 | Anticancer Res2000，20，60： | 1 |
| 6 | In rive Study of Trichoderma-pathogen-plant Interactions Using Constitutive and Inducible Green Fluorcscent Protein Reporter Systems显示文摘 | LU Z TOMBOLINI R WOO S | 2004 | Applied and Environmental Microbiology2004，70，5： | 1 |
| 7 | colonization pattern of the biocontrol strain Pseudomonas chlororaphis MA 342 on barley seeds visualized by using green fluorescent protein显示文摘 | Tombolini R Gaag D J Van Der Gerhardson B | 1999 | Applied and Environmental Microbiology1999，65，8： | 1 |
| 8 | Plant colonization by pink-pigmented facultative methylotrophic bacteria (PPFMs) 显示文摘 | Omer Z S Tombolini R Gerhardson B | 2004 | FEMS Microbiology Ecology2004，47，3： | 1 |
| 9 | Interaction between gfp- tagged Pseudomonas tolaasii P12 and Pleurotus eryngii显示文摘 | Russo A Filippi C Tombolini R | 2003 | Microbiological Research2003，158，3： | 1 |
| 10 | Simultaneous monitoring of cell number and metabolic activity of specific bacterial populations with a dual gfp - luxAB marker system 显示文摘 | Unge A Tombolini R Molbak L | 1999 | Applied and Environmental Microbiology1999，65，2： | 1 |
| 11 | In vivo study of Trichodermapathogen-plant interactions using constitutive and inducible green fluorcscent protein reporter systems显示文摘 | Lu Z Tombolini R Woo S | 2004 | Applied and Environmental Microbiology2004，70，5： | 1 |
| 12 | Monitoring of GFPtagged bacterial cells122显示文摘 | Tombolini R and Jansson J K | 1998 | Met Molecul Biol1998，102，： | 1 |
| 13 | Radiotherapy alone in elderly patients with medically inoperable stage ⅢA and Ⅱ-ⅠB non-small cell lung cancer显示文摘 | Tombolini V Bonanni A Donato V | 2000 | Antican Res2000，20，6： | 1 |
| 14 | In vivo study of Trichoderma-pathogen-plant interactions using constitutive and inducible green fluoresent protein reporter systems显示文摘 | LU Z X TOMBOLINI R WOO S | 2004 | Applied and En- vironmental Microbiology2004，70，5： | 1 |
| 15 | Fatal accidental ingestion of carbon tetrachloride: a postmortem distribution study 显示文摘 | Tombolini A Cingolani M | 1996 | J Forensic Sci1996，41，1： | 1 |
| 16 | Radiotherapy alone in elderly patients with medically inoperable stage Ⅲ A and ⅢB non-small cell lung cancer显示文摘 | Tombolini V Bonanni A Donato V | 2000 | Anticancer Res2000，20，6： | 1 |
| 17 | Simultaneous monitoring of cell number and metabolic activity of specific bacterial populations with a dual luxAB marker system显示文摘 | UNGE A TOMBOLINI R | 1999 | Applied and Environmental Microbiology1999，2，： | 1 |
| 18 | Radiotherapy alone in elderly patients with medically inoperable stage Ⅲ A and Ⅲ B non-small cell lung cancer显示文摘 | Tombolini V Bonanni A Donato V | 2000 | Anticancer Res2000，20，6： | 1 |
| 19 | In vivo study of Trichoderma-pathogen-plant interactions, using constitutive and inducible green fluorescent protein reporter systems显示文摘 | Lu Z Tombolini R Woo S | 2004 | Applied and Environmental Microbiology2004，70，： | 1 |
| 20 | Lithotripsy in the treament of urinary lithiasis显示文摘 | Tombolini P Ruoppolo M Bellorofonte C | 2000 | J Nephrol2000，，： | 1 |
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