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| 1 | Severe cutaneous adverse drug reactions: a review on epidemiology, etiology, clinical manifestation and pathogenesis显示文摘目的将在严重的皮肤的不利的药反应(SCADR ) 的传染病学,病原学,临床的表明,和 pathophysiology 考察当前的进步。数据来源数据被使用 Blackwell 协同作用, PubMed,在主要中国杂志出版的原来的文章和相关医药课本材料获得。在整个文学的学习选择和日期抽取考察 49 篇文章被选择。然而,结果 SCADR 盒子是稀罕的含意是与重要 mortatity 率威胁的生活。传染病学研究从不同区域,性,年龄,赛跑和并发的病显示出各种各样的发生。为 SCADR 的每种类型有典型症状,但是这不那么总是是。与导致 SCADR 联系的药是 anticonvulsants,抗菌素, NSAID 和治疗风湿药剂药。在一些国家,特别在亚洲,传统的药是 offen SCADR 的原因。基因多型性和病毒的感染是 SCADR 的倾向因素。有某些基因等位基因和内在的疾病的病人对 SCADR 脆弱。SCADR 的准确致病不是明确的。尽管如此,最近的学习证明反应代谢物和免疫学的过程在 SCADR 有一个重要角色。不同 SCADR 反应被不同内在的因素归因的结论例如象外来的因素一样的基因多型性,性,年龄和赛跑,例如内在的疾病。不同区域和犯人药也在 SCADR 的各种各样的类型起一个作用。 | Tomy Martin LI Hui | 2008 | Chinese Medical Journal2008，，8： | 18 |
| 2 | 超音速火焰喷涂碳化物粒径不同的WC-10Co4Cr涂层在粗细磨粒下的磨损性能显示文摘改进的ASTM G65橡胶轮测试方法可采用220nm二氧化钛颗粒和368μm的砂粒分别在潮湿和干燥条件下使用。在由碳化物粒径不同(传统和亚微米)的两种粉末所制备的WC-CoCr涂层上开展试验,研究碳化物大小和磨损介质特性对涂层磨损性能的影响。采用扫描电镜对同一位置磨损前后的低倍和高倍形貌进行观察,并分析了涂层的磨损机理。结果表明:磨损机理取决于碳化物和磨粒的相对大小。在样品上进行磨损定量分析,通过调整碳化物尺寸可改善磨损性能,测试涂层的一些力学性能用于对比。 | Arash Ghabchi Tommi Varis Erja Turunen Tomi Suhonen S-P Hannula 谢旭霞 | 2010 | 热喷涂技术2010，，4： | 15 |
| 3 | Advantages of white LED lamps and new detector technology in photometry显示文摘Light emitting diode(LED)lighting is becoming more and more popular,as incandescent lamps are being phased out globally.LEDs have several advantages over incandescent lamps,including energy efficiency,robustness,long lifetime,and good temporal stability.The three latter features make LEDs attractive candidates as new photometric standards.Because the spectra of white LEDs are limited to the visible wavelength range,a novel method for the realization of photometric units based on the predictable quantum efficient detector(PQED)can be utilized.The method eliminates the need of photometric filters that are traditionally used in photometry,and instead relies on carrying out the photometric weighting numerically based on the measured relative spectrum of the source.The PQED-based realization simplifies the traceability chain of photometric measurements significantly as compared with the traditional filter-based method.The measured illuminance values of a white LED deviate by only 0.03%when determined by the new and the traditional methods.The new PQED method has significantly lower expanded uncertainty of 0.26%(k=52)as compared with that of the traditional filter-based method of 0.42%(k=52).Furthermore,when filtered photometers that measure LED lighting are calibrated using LED lamps as calibration sources instead of incandescent lamps,a significant decrease in the uncertainty related to the spectral mismatch correction can be obtained.The maximum spectral mismatch errors of LED measurements decreased on average by a factor of 3 when switching from an incandescent lamp to an LED calibration source. | Tomi Pulli Timo Donsberg Tuomas Poikonen Farshid Manoocheri Petri Karha Erkki Ikonen | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 4 | 重症药疹85例临床分析显示文摘目的探讨重症药疹的临床特点及防治措施。方法对本科2002年8月-2013年11月诊治的重症药疹患者的临床资料进行回顾性分析。结果排名前三位的致敏药物分别为抗生素、抗癫痫药和解热镇痛药,最常见用药原因为感染。中成药引起的药疹内脏损害相对较轻。85例患者中,治愈61例,好转23例,1例死于肺部感染及呼吸衰竭。结论重症药疹是皮肤科危重病种,早期予以糖皮质激素联合免疫球蛋白效果较好,同时应加强对症及支持治疗。 | 申卉 Tomy Martin 李惠 | 2015 | 中国皮肤性病学杂志2015，29，4： | 8 |
| 5 | Clustering Structure Analysis in Time-Series Data With Density-Based Clusterability Measure显示文摘Clustering is used to gain an intuition of the struc tures in the data.Most of the current clustering algorithms pro duce a clustering structure even on data that do not possess such structure.In these cases,the algorithms force a structure in the data instead of discovering one.To avoid false structures in the relations of data,a novel clusterability assessment method called density-based clusterability measure is proposed in this paper.I measures the prominence of clustering structure in the data to evaluate whether a cluster analysis could produce a meaningfu insight to the relationships in the data.This is especially useful in time-series data since visualizing the structure in time-series data is hard.The performance of the clusterability measure is evalu ated against several synthetic data sets and time-series data sets which illustrate that the density-based clusterability measure can successfully indicate clustering structure of time-series data. | Juho Jokinen Tomi Raty Timo Lintonen | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 6 |
| 6 | THE USE OF PLANE WAVES TO APPROXIMATE WAVE PROPAGATION IN ANISOTROPIC MEDIA显示文摘在这篇论文,我们在各向同性的媒介扩大麦克斯韦的方程的标准极端弱变化明确的表达(UWVF ) 到各向异性的媒介的盒子。我们证实内在的理论框架带在上到各向异性的媒介(然而,错误估计是还没可得到的) 并且完全描述新计划。我们然后考虑 TM 模式散布,显示出这怎么与一个各向异性的系数在二种尺寸导致一个 Helmholtz 方程并且表明怎么提出为它的 UWVF。在一种特殊情况中,集中能被证明。我们然后显示出建议的一些数字结果 UWVF 能成功地在各向异性的媒介模仿波浪繁殖。 | Tomi Huttunen Peter Monk | 2007 | Journal of Computational Mathematics2007，25，3： | 5 |
| 7 | 采用高浓臭氧漂白 生产高强度浆料 降低废水排放显示文摘位于斯洛伐克的Mondi Business Paper SCP纸厂,为提高制浆生产能力和浆料质量,并降低对环境的影响,对整个制浆生产线进行改造并增加OxyTrac氧脱木素和ZeTrac臭氧漂白。本文介绍了改造前后的工艺流程、改造的效果与特点、生产线优化等。整个制浆生产线的改造由美卓负责,美卓提供了主要设备以及进行工程设计。 | Borivoj Tomis | 2007 | 中华纸业2007，28，9： | 4 |
| 8 | 嗜酸性粒细胞增多综合征1例显示文摘1病历摘要
患者男,63岁。因全身红斑、丘疹伴瘙痒5年,加重1个月,于2007年1月10日入院。患者5年前无明显诱因腹部出现红斑及米粒大丘疹,伴剧烈瘙痒,影响睡眠。患者曾自服中药(具体不详),病情可好转。丘疹逐渐蔓延至胸部、臀部、四肢、颈部及头部,无季节性变化。入院1个月瘙痒加重。余无异常。家族中无类似疾病患者。 | Tomy Martin 李惠 陈爱军 | 2008 | 临床皮肤科杂志2008，37，3： | 4 |
| 9 | Local corticosterone production and angiotensin-Ⅰconverting enzyme shedding in a mouse model of intestinal inflammation显示文摘AIM: To investigate local corticosterone production and angiotensin-Ⅰ converting enzyme(ACE) protein expression and their interaction in healthy and inflamed intestine.METHODS: Acute intestinal inflammation was induced to six weeks old male Balb/c mice by administration of either 3% or 5% dextran sodium sulfate(DSS) in drinking water for 7 d(n = 12 in each group). Healthy controls(n = 12) were given tap water. Corticosterone production and ACE protein shedding were measured from ex vivo incubates of the small and large intestine using EIA and ELISA, respectively. Morphological changes of the intestinal wall were assessed in hematoxylin-eosin stained tissue preparations of jejunum and distal colon. Effects of angiotensin Ⅱ, captopril and metyrapone on corticosterone production was assessed by incubating pieces of small intestine of healthy mice in the presence of 0.1, 1 or 10 μmol/L angiotensin Ⅱ, 1, 10 or 100 μmol/L captopril or 1, 10 or 100 μmol/L metyrapone solutions and measuring corticosterone released to the incubation buffer after 90 min(n = 5 in each group).RESULTS: Both concentrations of DSS induced inflammation and morphological changes in large intestines but not in small intestines. Changes were observed as distortions of the crypt structure, mucosal erosion, immune cell infiltration to the mucosa and submucosal edema. Ex vivo corticosterone production(2.9 ± 1.0 ng/mL vs 2.0 ± 0.8 ng/mL, P = 0.034) and ACE shedding(269.2 ± 97.1 ng/m L vs 175.7 ± 52.2 ng/mL, P = 0.016) were increased in small intestines in 3% DSS group compared to the controls. In large intestine, corticosterone production was increased compared to the controls in both 3% DSS(229 ± 81 pg/mL vs 158 ± 30 pg/mL, P = 0.017) and 5% DSS groups(366 ± 163 pg/mL vs 158 ± 30 pg/mL, P = 0.002). Large intestine ACE shedding was increased in 5% DSS group(41.5 ± 9.0 ng/mL vs 20.9 ± 5.2 ng/mL, P = 0.034). Angiotensin Ⅱ treatment augmented corticosterone production in small intestine at concentration of 10 μmol/L(0.97 ± 0.21 ng/mg protein vs 0.40 ± 0.09 ng/mg protein, P = 0.036).CONCLUSION: Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin Ⅱ stimulates corticosterone formation in healthy intestine. | Hanne Salmenkari Tomi Issakainen Heikki Vapaatalo Riitta Korpela | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 10 | Vehicle-to-grid power fundamentals: Calculating capacity and net revenue显示文摘 | Willett Kempton Jasna Tomi? | 2005 | Journal of Power Sources2005，，1： | 2 |
| 11 | Using fleets of electric-drive vehicles for grid support显示文摘 | Jasna Tomi? Willett Kempton | 2007 | Journal of Power Sources2007，，2： | 2 |
| 12 | 扁桃斑鸠菊及非洲印楝叶的提取物对链脲佐菌素致糖尿病大鼠肝脏形态学及肝毒性标志物的影响(英文)显示文摘目的:研究扁桃斑鸠菊及非洲印楝叶的提取物对链脲佐菌素致糖尿病大鼠肝脏形态学、肝脏氧化性应激标志物及部分肝脏酶类的影响。方法:大鼠腹腔注射链脲佐菌素致糖尿病。不同治疗组大鼠分别口服扁桃斑鸠菊及非洲印楝叶的提取物(500mg/kg)或二甲双胍(150mg/kg),疗程8周,每周测量大鼠的血糖水平及体质量变化。8周后麻醉处死大鼠。取肝组织制成切片,希夫染色法染色,并测量肝匀浆中丙二醛和谷胱甘肽过氧化物酶的含量;下腔静脉采血,分离血浆,检测血浆中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的活性。结果:二甲双胍及植物提取物均能显著改善糖尿病大鼠的血糖水平,且与糖尿病模型组相比,治疗组的体质量明显增加(P<0.05)。光学显微镜下,各组大鼠的肝脏形态学无明显差别。植物提取物治疗组大鼠的血浆丙氨酸氨基转移酶及天冬氨酸氨基转移酶的活性与正常对照组相比无明显变化(P>0.05),而丙二醛含量明显下降(P<0.05)。结论:扁桃斑鸠菊及非洲印楝叶的提取物对糖尿病大鼠有明显的降糖作用,而肝脏形态学及肝毒性标志物没有明显变化。 | Oluwole Busayo Akinola Gabriel Olaiya Omotoso Oluwafunmike Sharon Akinola Olufunke Olubusola Dosumu Esther Tomi Adewoye | 2011 | 中西医结合学报2011，9，12： | 2 |
| 13 | Self-Learning of Multivariate Time Series Using Perceptually Important Points显示文摘In machine learning,positive-unlabelled(PU)learning is a special case within semi-supervised learning.In positiveunlabelled learning,the training set contains some positive examples and a set of unlabelled examples from both the positive and negative classes.Positive-unlabelled learning has gained attention in many domains,especially in time-series data,in which the obtainment of labelled data is challenging.Examples which originate from the negative class are especially difficult to acquire.Self-learning is a semi-supervised method capable of PU learning in time-series data.In the self-learning approach,observations are individually added from the unlabelled data into the positive class until a stopping criterion is reached.The model is retrained after each addition with the existent labels.The main problem in self-learning is to know when to stop the learning.There are multiple,different stopping criteria in the literature,but they tend to be inaccurate or challenging to apply.This publication proposes a novel stopping criterion,which is called Peak evaluation using perceptually important points,to address this problem for time-series data.Peak evaluation using perceptually important points is exceptional,as it does not have tunable hyperparameters,which makes it easily applicable to an unsupervised setting.Simultaneously,it is flexible as it does not make any assumptions on the balance of the dataset between the positive and the negative class. | Timo Lintonen Tomi Raty | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 2 |
| 14 | Rotor vibration due to collision with annular guard during passage through critical speed 显示文摘 | Yanabe S Kaneko S Kanemitsu Y Tomi N Sugiyama K | 1998 | ASME Journal of Vibration and Acoustics1998，120，： | 1 |
| 15 | Developmental expression of key steroidogenie enzymes in the brain of protandrous black porgy fisb, Acanthopagrus sehlegeli 显示文摘 | Tomy S Wu G C Huang H R | 2007 | Neuroendoerinol2007，9，8： | 1 |
| 16 | Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines显示文摘 | Eija K Tomi R Vootele V | 2005 | Cell Mol Neurobiol2005，25，6： | 1 |
| 17 | Vehicle-to-grid power implementation: From stabilizing the grid to supporting large-scale renewable energy显示文摘 | Willett Kempton Jasna Tomi? | 2005 | Journal of Power Sources2005，，1： | 1 |
| 18 | Identification and quantitative determination of furanodiene, a heat-sensitive compound, in essential oil by ^13C-NMR显示文摘 | Baldovini N Tomi F Casanova J | 2001 | Phytochem Anal2001，12，： | 1 |
| 19 | Scientific barriers to developing vaccines against avian influenza viruses 显示文摘 | Kanta S Tomy J | 2007 | Nature Reviews2007，7，： | 1 |
| 20 | Dietary accumulation and quantitative structure activity relationships for depuration and bio- transformation of short, medium and long carbon chain polychlori- nated alkenes by juvenile rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | Fish A T Tomy G T Cymbalisty C D | 2000 | Environ Toxicol Chem2000，19，： | 1 |
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