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| 1 | Association of a genetic variant in AKT1 gene with features of the metabolic syndrome显示文摘Metabolic syndrome(MetS)is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 diabetes.There is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and obesity.We aimed to investigate the association between MetS and its components with the genetic polymorphism in AKT1,rs1130233(T>C).Total of 618 participants,recruited from Mashhad stroke and heart atherosclerosis disorder cohort(MASHAD study).Patients with MetS were defined by using international diabetes federation(IDF)criteria(n Z 326)and those without MetS(n Z 261)were recruited.Anthropometric and biochemical parameters were measured in all subjects.Genetic analysis for the rs1130233 polymorphism was performed,using the ABI-StepOne instruments with SDS version-2.0 software.Individuals with MetS had a significantly higher levels of BMI,waistcircumference,total cholesterol,triglyceride,high sensitivity-c reactive protein(hs-CRP)and blood-pressure,and lower concentrations of high density lipoprotein(HDL-C),compared to non-MetS individuals(P<0.05).The association between the rs1130233 and MetS was not significant.Subjects with a CC or CT genotypes had a significantly higher serum hs-CRP-level(OR:1.5;95%CI(1.05e2.1),P Z 0.02).Additionally,subjects who carried the TC genotype had a higher BMI compared to the CC genotype(p value Z 0.045).Our findings demonstrated that AKT1,rs1130233(T>C)polymorphism was associated with major components of MetS such as hs-CRP,and BMI,indicating further investigation in a multi-center setting to explore its value as an emerging biomarker of risk stratification marker. | Fateme Sadat Eshaghi Hamideh Ghazizadeh Sakine Kazami-Nooreini Ameneh Timar Habibollah Esmaeily Mehrane Mehramiz Amir Avan Majid Ghayour-Mobarhan | 2019 | Genes & Diseases2019，6，3： | 6 |
| 2 | Identification and clinical significance of circulating end othelial progenitor ceils in human non-small cell lung caneer Prospective identification of tumorigenic breast cancer ceils 显示文摘 | Dome B Timar J Dobos J | 2006 | Cancer Res2006，66，14： | 1 |
| 3 | Genomics of lung cancer may change diagnosis, prognosis and therapy 显示文摘 | Kopper L Timar J | 2005 | Pathol Oncol Res2005，11，1： | 1 |
| 4 | Dose-dependent effect of folie acid on the prevention of orofaeial clefts显示文摘 | Czeizel AE Timar L Sarkozi A | 1999 | Pediatrics1999，104，6： | 1 |
| 5 | The cost-effectiveness of ulipristal acetate tablets in treating patients with moderate to severe symtoms of uterine fibroids显示文摘 | Nagy B Timar G Jozwiak-Hagymasy J | 2014 | Eur J Obstet Gynecol Reprod Biol2014，，175： | 1 |
| 6 | Improving the corn processing 显示文摘 | RUSKA L TIMAR A | 2010 | Natural Resources and Sustainable Development2010，，2010： | 1 |
| 7 | Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone显示文摘 | Somberg JC Timar S Bailin SJ | 2004 | Am J Cardiol2004，93，5： | 1 |
| 8 | Association of microvessel density with infiltrating cells in human cutaneous malignant melanoma显示文摘 | Kiss J Timar J Somlai B | 2007 | Pathol Oncol Res2007，13，1： | 1 |
| 9 | A real-time multitarget tracking system with robust multichannel CNN-UM algorithms显示文摘 | Timar G Rekeezky C | 2005 | IEEE Trans Circuits and Systems2005，52，7： | 1 |
| 10 | Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone显示文摘 | Somberg JC Timar S Bailin SJ | 2004 | Am J Cardiol2004，93，5： | 1 |
| 11 | Modulation of heparan sulfate/chondroitin sulfate ratio by glycosaminooglycan biosynthesis inhibitors affects liver metabolic pootential of tumor cells 显示文摘 | Timar J Diczhazi C Bartha I | 1995 | Int J Cancer1995，62，6： | 1 |
| 12 | Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer显示文摘 | Dome B Timar J Dobos J | 2006 | Cancer Res2006，66，14： | 1 |
| 13 | Invasive growth and topoisomerase-switch induced by tumorous extracellular matrix in osteosarcoma cell culture显示文摘 | Harisi R Dudas J Timar F | 2005 | Cell Biol Int2005，29，11： | 1 |
| 14 | TH1/TH2 imbalance,measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease显示文摘 | Szodoray P Timar O Veres K | 2006 | Scand J Immunol2006，64，3： | 1 |
| 15 | Lack of a new aqueous formulation of intravenous amiodarone显示文摘 | Somberg JC Timar S Bailin SJ | 2004 | Am J Cardiol2004，3，5： | 1 |
| 16 | Biological resistance of chemically modified aspen composites 显示文摘 | TIMAR M C PITMAN A MIHAI M D | 1999 | International Biodeterioration and Biodegradation1999，43，： | 1 |
| 17 | Changes of calcium distribution in ovules of Torenia fournieri during pollination and fertilization显示文摘 | KRISTOF Z TIMAR O IMRE K | 1999 | Protoplasma1999，208，14： | 1 |
| 18 | Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CIM/CD8 ratio and tumor microenvironment: a multicenter phase Ⅱ clinical trial显示文摘 | TIMAR J LADANYI A FORSTER-HORVATH C | 2005 | J Clin Oncol2005，23，15： | 1 |
| 19 | Compounding bromobutyl for heat -resistance显示文摘 | Timar J Edwards W S | 1979 | Rubber Chemistry & Technology1979，52，2： | 1 |
| 20 | The impact of diabetic neu- ropathy on balance and on the risk of fails in patients with type 2 diabetes mellitus : a cross-sectional study 显示文摘 | TIMAR B TIMAR R GAITA L | 2016 | PLoS One2016，11，01： | 1 |
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