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| 1 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 2 | Surgery induced in sulin resistance in human patients 显示文摘 | Thorell A Brooks Murry D | 1999 | Am J physiol1999，276，4： | 1 |
| 3 | Insulin resistance:a marker of surgical stress显示文摘 | Thorell A Nygren J Ljungqvist O | 1999 | Curr Opin Clin Nutr Metab Care1999，2，1： | 1 |
| 4 | Insulin resistance and elective surgery 显示文摘 | Ljungqvist O Nygren J Thorell A | 2000 | Surgery2000，128，5： | 1 |
| 5 | Insulin resistance and elective surgery 显示文摘 | Ljungqvist O Nygren J Thorell A | 2000 | Surgery2000，128，5： | 1 |
| 6 | Modulation of post-operative insulin resistance by pre-operative carbohydrate loading显示文摘 | Ljungqvist O Nygren J Thorell A | 2002 | Pro Nutr Soc2002，61，3： | 1 |
| 7 | Randomized clinical trial of the effects of oral preoperative carbohydrates on postoperative nausea and vomiting after laparoscopic cholecystectomy 显示文摘 | Hause! J Nygren J Thorell A | 2005 | Br J Surg2005，92，4： | 1 |
| 8 | Context-specific alpha- to- beta-cell reprogramming by forced Pdxl expression 显示文摘 | Yang YP Thorel F Boyer DF | 2011 | Genes Dev2011，25，16： | 1 |
| 9 | Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3days after surgery显示文摘 | Soop M Nvgren J Thorell A | 2004 | Clin Nutr2004，23，4： | 1 |
| 10 | Lichtenstein, Prolene Hernia System, and UltraPro Hernia System for primary inguinal hernia repair: one-year outcome of a prospective randomized controlled trial显示文摘 | Magnusson J Nygren J Thorell A | 2012 | Hernia2012，16，3： | 1 |
| 11 | Insulin resistance after abdominal surgery显示文摘 | Thorell A Efendic S Gutniak M | 1994 | Br J Surg1994，81，1： | 1 |
| 12 | Insulin resistance and elective surgery显示文摘 | Ljungqvist O Nygren J Thorell A | 2000 | Surgery2000，128，5： | 1 |
| 13 | Lateral cyclicloading of sand-installed pi!es显示文摘 | ROSQUOET F THOREL L GARNIER J | 2007 | Soils and foundations2007，47，82： | 1 |
| 14 | Effects of 3 days of ' postoperative' low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects 显示文摘 | Svanfeldt M Thorell A Brismar K | 2003 | Clin Nutr2003，22，： | 1 |
| 15 | New developments facilitating nutritional intake after gastrointestinal surgery显示文摘 | Nygren J Thorell A Ljungqvist O | 2003 | Curt Opin Clin Nutr Metab Care2003，6，5： | 1 |
| 16 | The Community Parent Education Program (COPE) : treatment effects in a clinical and a communitybased sample显示文摘 | Thorell LB | 2009 | Clin Child Psychol Psychiatry2009，14，3： | 1 |
| 17 | Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss显示文摘 | Thorel F Nepote V Avril I | 2010 | Nature2010，464，7292： | 1 |
| 18 | The effect of diverting stoma on postoperative morbidity after low anterior resection for rectal cancer in patients treated within an ERAS program显示文摘 | Anderin K Gustafsson UO Thorell A | 2015 | Eur J Surg Oncol2015，41，： | 1 |
| 19 | Insulin resistance: a marker of surgical stress显示文摘 | Thorell A Nygren J Ljungqvist O | 1999 | Curr Opin Clin Nutr Metab Care1999，2，1： | 1 |
| 20 | Preoperative oral carbohydrate nutrition:an update显示文摘 | NYGREN J THORELL A LJUNGQVIST O | 2001 | Curr Opin Clin Nutr Metab Care2001，4，4： | 1 |
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