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| 1 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 2 | Long- ABO-incompatible liver transplantation显示文摘 | Varela-Fascinetto G Treacy SJ term results in pediatric Lillehei CW | 1999 | Transplant Proc1999，31，12： | 1 |
| 3 | VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer显示文摘 | Terme M Pernot S Marcheteau E | 2013 | Cancer Res2013，73，2： | 1 |
| 4 | Prevention of cardiovasculsr events and death with pravastatinary head disease and abroad range of initial cholestol levels显示文摘 | The long term Intervention with Pravastatin in Ischemic Disease(LIPID)study Group | 1998 | N Eng1 J Med1998，339，19： | 1 |
| 5 | Definition and classification of power system stability 显示文摘 | IEEE/CIGILE joint task force on stability terms and definition | 2004 | IEEE Trans on Power Systems2004，19，2： | 1 |
| 6 | Deduced protein sequence of bone small proteoglycanⅠ(biglycan) shows homology with proteoglycanⅡ(decorin) and several nonconnective tissue proteins in a variety of species显示文摘 | Fisher L W Term ine J D Young M F | 1989 | J Biol Chem1989，264，8： | 1 |
| 7 | Prevention of Cardiovascular events and death with Pravastain in patients with coronary heart disease and a broad range of initial cholesterol levels显示文摘 | The long term Intervetion with Pravastain in Ischemic Disease(LIPID)Study group | 1998 | N Engl J Med1998，339，9： | 1 |
| 8 | The long protective rust layer formed on weathering steel by atmospheric corrosion during a quarter of a century 显示文摘 | Jing Gui Deuine T term growth of the M | 1994 | Corros Sci1994，34，4： | 1 |
| 9 | Proposed terms and definitions for flexible AC transmission systems (FACTS)显示文摘 | FACTS Terms & Definitions Task Force of the FACTS Working Group of the DC and FACTS Subcommittee | 1997 | IEEE Trans on Power Delivery1997，12，4： | 1 |
| 10 | Tumor-infiltrating regulatory T eells: phenotype, role, meehanism of expansion in situ and clinical siguifieance 显示文摘 | Tanehot C Terme M Pere H | 2013 | Cancer Miereenviron2013，6，2： | 1 |
| 11 | Definition and classification of power system stability显示文摘 | IEEE/CIGRE joint task force on stability terms and definitions | 2004 | IEEE Transactions on Power System2004，19，2： | 1 |
| 12 | Definition and classification of power system stability显示文摘 | IEEE/CIGRE joint task force on stability terms and definitions | 2004 | IEEE Trans on Power Systems2004，19，2： | 1 |
| 13 | Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels显示文摘 | The Long- Term Intervention With Pravastatin In Ischaemic Disease (Lipid) Study Group | 1998 | N Engl J Med1998，339，： | 1 |
| 14 | Definition and classification of power system stability显示文摘 | IEEE/CIGRE Joint Task Force on Stability Terms and Definitions | 2004 | IEEE Transactions On Power Systems2004，19，2： | 1 |
| 15 | Definition and classification of power systemstability 显示文摘 | IEEE/CIGRE Joint Task Force on Stability Terms andDefinitions | 2004 | IEEE Trans on Power Systems2004，19，2： | 1 |
| 16 | CD4+ CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner 显示文摘 | Ghiringhelli F Menard C Terme M | 2005 | J Exp Med2005，202，： | 1 |
| 17 | Infective outcome 显示文摘 | Netzer R O endocarditis : Altwegg S C determinants Zollinger E of long term | 2002 | Heart2002，88，1： | 1 |
| 18 | Natural killer cell-directed therapies:movingfrom unexpected results to successful strategies显示文摘 | TERME M ULLRICH E DELAHAYE N F | 2008 | Nat Immunol2008，9，5： | 1 |
| 19 | CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner显示文摘 | Ghiringhelli F M6nard C Terme M | 2005 | J Exp Med2005，202，： | 1 |
| 20 | The Academy of Prosthodontics 显示文摘 | | 1994 | J Prosthet Dent1994，71，1： | 1 |
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