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| 1 | Brain activity of anandamide:a rewarding bliss?显示文摘Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors.These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol,the psychoactive ingredient in Cannabis sativa.Several studies demonstrate that anandamide exerts an overall modulatory effect on the brain reward circuitry.Several reports suggest its involvement in the addiction-producing actions of other abused drugs,and it can also act as a behavioral reinforcer in animal models of drug abuse.Importantly,all these effects of anandamide appear to be potentiated by pharmacological inhibition of its metabolic degradation.Enhanced brain levels of anandamide after treatment with inhibitors of fatty acid amide hydrolase,the main enzyme responsible for its degradation,seem to affect the rewarding and reinforcing actions of many drugs of abuse.In this review,we will provide an overview from a preclinical perspective of the current state of knowledge regarding the behavioral pharmacology of anandamide,with a particular emphasis on its motivational/reinforcing properties.We will also discuss how modulation of anandamide levels through inhibition of enzymatic metabolic pathways could provide a basis for developing new pharmaco-therapeutic tools for the treatment of substance use disorders. | Maria Scherma Paolo Masia Valentina Satta Walter Fratta Paola Fadda Gianluigi Tanda | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 2 | Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy显示文摘 | Sasaki T Jyo Y Tanda N | | 0，，： | 2 |
| 3 | Effects of nicotine on the nucleus aecnmbens and imilarity to those of addictive drugs 显示文摘 | PONTIERI FE TANDA G ORZI F | 1996 | Nature1996，382，6588： | 1 |
| 4 | Histological analysis on adhesive molecules of renal intravascular large B cell lymphoma CHOP chemotherapy and rituximab显示文摘 | Hatta T Tanda S | 2006 | Clin Nephrol2006，65，3： | 1 |
| 5 | Impulse function and drag in seramjet inlet models显示文摘 | TANDA T TANI K | 1996 | Journal of Propulsion and Power1996，12，6： | 1 |
| 6 | Fluctuations in tumor blood flow under normotension and the effect of angiotensin Ⅱ-induced hypertension显示文摘 | Hori k SuzukiM Tanda S | 1991 | Jpn J Cancer Res1991，82，11： | 1 |
| 7 | Muhiuser detection in impulsive channels 显示文摘 | POOR H V TANDA M | 1999 | Annales DES Telecommunications-annals of Telecommunications1999，54，8： | 1 |
| 8 | Expression of apoptotic signal-ing proteins in leukoplakia and oral lichen planus: Quantitative and to- pographical studies 显示文摘 | Tanda N Mori S Saito K | 2000 | J Oral Pathol Med2000，29，8： | 1 |
| 9 | Intravenous cocaine, morphine, and amphetamine prderentially increase extracellular dopamine in the 'shell' as compared with the 'core' of the rat nucleus accumbens显示文摘 | Pontieri FE Tanda G Di Chiara G | 1995 | Proc Natl Acad Sci USA1995，92，12： | 1 |
| 10 | Fluctuations in tumor blood flow under normotension and the effect of angiotensin Ⅱ-induced hypertension显示文摘 | Hori K Suzuki M Tanda S | 1991 | JpnJ Cancer Res1991，82，11： | 1 |
| 11 | On the second-order cyclostationarity properties of longcode DS-SS signals显示文摘 | FUSCO T IZZO L NAPOLITANO A TANDA M | | 0，，10： | 1 |
| 12 | Comparison of theeffectiveness and tolerability of intravenous or oralglucocorticoids associtated with orbital radiotherapy in themanagement of severe Graves' ophthalmopathy: results of aprospective single-blind, randomized study 显示文摘 | Marcacci C Bartalena L Tanda M | 2001 | J ClinEndocrinol Metab2001，86，8： | 1 |
| 13 | Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced acctmabal dopamine release 显示文摘 | Munzar P Tanda G Justinova Z | 2004 | Neuropsychopharmacology2004，29，： | 1 |
| 14 | Impulse function and drag in scramjet inlet models 显示文摘 | Tanda T Tani K | 1996 | Journal of Propulsion and Power1996，12，6： | 1 |
| 15 | Fatal hyperpyrexia after withdrawal of levodopa显示文摘 | Sechi GP Tanda F Mutani R | 1984 | Neurology1984，34，2： | 1 |
| 16 | Isolated ACTH deficiency in a late onset case of hypogonadism (LOH) not diagnosed by examination in an internal medicine clinic 显示文摘 | Sato Y Tanda H Kato S | 2008 | Hinyokika Kiyo2008，54，： | 1 |
| 17 | Prevalence and natural history of Graves′ orbitopathy in the XXI century显示文摘 | Piantanida E Tanda ML Lai A | 2013 | J Endocrinol Invest2013，36，6： | 1 |
| 18 | An update on medical management of Graves'ophthalmopathy显示文摘 | Bartalena L Marcocci C Tanda ML | 2005 | J Endocrinol Invest2005，28，5： | 1 |
| 19 | Fatal hyperpyrexia after withdra-wal of levodopa显示文摘 | Sechi GP Tanda F Mutani R | 1984 | Neurology1984，34，2： | 1 |
| 20 | Cigarette smoking and the thyroid显示文摘 | BARTALENA L BOGAZZI F TANDA M L | 1995 | Eur J Endocrinol1995，133，5： | 1 |
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