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| 1 | Meckel's diverticulum masked by a long period of intermittent recurrent subocclusive episodes显示文摘Meckel's diverticulum(MD) is the most frequent congenital abnormality of the small bowel and it is often diff icult to diagnose.It is usually asymptomatic but approximately 4% are symptomatic with complications such as bleeding,intestinal obstruction,and inflammation.The authors report a case of a 7-year-old boy with a one-year history of recurrent periumbilical colicky pain with associated alimentary vomiting,symptoms erroneously related to a cyclic vomiting syndrome but not to MD.The clinical features and the differential diagnostic methods employed for diagnosis of MD are discussed. | Daniela Codrich Andrea Taddio Jurgen Schleef Alessandro Ventura Federico Marchetti | 2009 | World Journal of Gastroenterology2009，15，22： | 3 |
| 2 | Crohn's disease and Takayasu's arteritis: An uncommon association显示文摘Takayasu’s arteritis(TA)and Crohn’s disease(CD)are two rare autoimmune disorders;however some reports describe the presence of both diseases in the same patient.This finding has suggested the possibility that both diseases could share some common etiologic origin.We describe a case of a 13-year-old male affected by CD characterized by fever,diarrhea,weight loss,abdominal pain and elevation of inflammatory markers.Clinical and histological features from colonic specimens were consistent with CD.Treatment with steroids and azathioprine was started,however disease flared every time steroids were tapered.One year later,while still on treatment,he came back to our attention for dyspnea at rest and at night,tiredness and weakness.At physical examination a diastolic heart murmur was found as well as a left carotid artery bruit.A transthoracic echocardiography showed mild aortic valve insufficiency,left ventricular hypertrophy and a dilated ascending aorta with same findings at the aortic arch.A computed tomography scan showed abdominal aortathickening,dilated thoracic aorta and the presence of a thoracic aortic aneurysm.TA associated with CD was diagnosed and medical treatment with cyclophosphamide,steroids and aminosalicylic acid was started,with good clinical response at 6 mo follow-up.We discuss the presence of possible common causes for the two diseases and the importance of differential diagnosis in those patients characterized for intractable disease. | Andrea Taddio Massimo Maschio Stefano Martelossi Egidio Barbi Alessandro Ventura | 2013 | World Journal of Gastroenterology2013，19，35： | 3 |
| 3 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 4 | Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center显示文摘AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.METHODS Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, which was effective in 6. Symptoms resolution occurred in 2 patients with UPF at last follow-up. Classification according to the PRINTOEurofever score did not correlate with treatment response and prognosis. CONCLUSION UPF is not a rare diagnosis among patients with periodic fever. Clinical presentation place UPF half way on a clinical spectrum between PFAPA and HPF. The PRINTOEurofever score is not useful to predict clinical outcome and treatment response in these patients. | Silvia De Pauli Sara Lega Serena Pastore Domenico Leonardo Grasso Anna Monica Rosaria Bianco Giovanni Maria Severini Alberto Tommasini Andrea Taddio | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 2 |
| 5 | Neonatal pain response to beel stick vs venepuncture for routine blood sampling显示文摘 | Shah VS Taddio A Bennett S | 1997 | Arch Dis Child Fetal Neonatal Ed1997，77，： | 2 |
| 6 | Conditioning and hyperalgesia in newborns exposed to repeated heel lances 显示文摘 | Taddio A Shah V Gilbert-MaeLeod C | 2002 | JAMA2002，288，7： | 1 |
| 7 | Prevalence of de-pression during pregnancy:systematic review显示文摘 | BENNETT H A EINARSON A TADDIO A | 2004 | Obstet Gynecol2004，103，4： | 1 |
| 8 | Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children:a randomized controlled trial显示文摘 | Taddio A Soin H K Schuh S | 2005 | CMA J2005，172，13： | 1 |
| 9 | Steady improvement of prothrombin levels after cyclophosphamide therapy in pe- diatric lupus anticoaculant hypoprothrombinemia syndrome (LAHPS) 显示文摘 | Taddio A Brescia AC Lepore L | 2007 | Clin Rheumatol2007，26，12： | 1 |
| 10 | Effect of neonatal circumcision on pain response during subsequent routine vaccination显示文摘 | Taddio A Katz J Ilersich AL | 1997 | Lancet1997，349，： | 1 |
| 11 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) o-earn, is it safe and efficacious in preterm infants? 显示文摘 | Stevens B Johnston C Taddio A | 1999 | J Dev Behav Pedialr1999，20，4： | 1 |
| 12 | Prevention of flare recurrences in childhood-refrac- tory chronic uveit is:an open-label comparative study of adali- mumab versus infliximab 显示文摘 | Simonini G Taddio A Cattalini M Caputo R De Libero C Nav- iglio S | 2011 | Arthritis CareRes ( Hoboken )2011，63，4： | 1 |
| 13 | Prevalence of de- pression during pregnancy:systematic review显示文摘 | Bennett HA Einarson A Taddio A | 2004 | Obstet Gy- necol2004，103，4： | 1 |
| 14 | Safety of benzodiazepines in newborns显示文摘 | Ng E Klinger G Taddio A | 2002 | Ann Pharmacother2002，36，： | 1 |
| 15 | Reducing the pain of childhood vaccination:an evidence-based clinical practice guideline显示文摘 | Taddio A Appleton M Bortolussi R | 2010 | CMAJ2010，，18： | 1 |
| 16 | Reliability and validity of ob- server tatings of pain using the visual analog scale(VAS)in infants undergoing immunizatoin injections 显示文摘 | Taddio A O'Brien L Ipp M | 2009 | Pain2009，147，13： | 1 |
| 17 | A critical re- view of the topical local anesthetic amethocaine (Ametop) for pediatric pain显示文摘 | O'Brien L Taddio A Lyszkiewiez DA | 2005 | Paediatr Drugs2005，7，1： | 1 |
| 18 | Excretion of fluoxetine andits metabolite, norfluoxetine, in human breast milk显示文摘 | Taddio A Ito S Koren G | 1996 | J Clin Pharmacol1996，36，1： | 1 |
| 19 | Conditioning and hyperalgesia in newborns exposed to repeated heel lanc- es显示文摘 | Taddio A Shah V Gilbert-MacLeod C | 2002 | JAMA2002，288，7： | 1 |
| 20 | Acute febrile cholestatic jaundice in children: keep in mind Kawasaki disease 显示文摘 | Taddio A Pellegrin MC Centenari C | 2012 | J Pediatr Gastroenterol Nutr2012，55，4： | 1 |
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