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	题名	作者	年代	出处	被引量
1	Alzheimer’s in a dish-induced pluripotent stem cell-based disease modeling显示文摘Background:Since the discovery of the induced pluripotent stem cell(iPSC)technique more than a decade ago,extensive progress has been made to develop clinically relevant cell culture systems.Alzheimer’s disease(AD)is the most common neurodegenerative disease,accounting for approximately two thirds of all cases of dementia.The massively increasing number of affected individuals explains the major interest of research in this disease as well as the strong need for better understanding of disease mechanisms.Main body:IPSC-derived neural cells have been widely used to recapitulating key aspects of AD.In this Review we highlight the progress made in studying AD pathophysiology and address the currently available techniques,such as specific differentiation techniques for AD-relevant cell types as well as 2D and 3D cultures.Finally,we critically discuss the key challenges and future directions of this field and how some of the major limitations of the iPSC technique may be overcome.Conclusion:Stem cell-based disease models have the potential to induce a paradigm shift in biomedical research.In particular,the combination of the iPSC technology with recent advances in gene editing or 3D cell cultures represents a breakthrough for in vitro disease modeling and provides a platform for a better understanding of disease mechanisms in human cells and the discovery of novel therapeutics.	Sherida de Leeuw Christian Tackenberg	2019	Translational Neurodegeneration2019，8，1：	1
2	Immunosuppressive treatment of ocular myasthenia gravis显示文摘	Tackenberg B Hemmer B Oertel WH	2001	Bio Drugs2001，15，36：	1
3	NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss显示文摘	Tackenberg C Grinschgl S Trutzel A	2013	Cell Death Dis2013，4，4：	1
4	Clonal expansions of CD4 + B helper T cells in autoimmune myasthenia gravis显示文摘	Tackenberg B Kruth J Bartholomaeus JE	2007	Eur J Immunol2007，37，3：	1
5	The association of multiple personality and temporalimbic epilepsy 显示文摘	Ahern GL Herring AM Tackenberg J	1993	Arch Neurol1993，50，10：	1
6	Impaired inhibitory Fcgamma receptor ]IB expression on B cells in chronic inflammatory demyelinating polyneuropathy显示文摘	Tackenberg B Jelcic I Baerenwaldt A	2009	Proc Natl Acad Sci USA2009，106，12：	1
7	Encapsulation of liquids using a counter twin screw extruder显示文摘	Tackenberg M W Krauss R Marmann A	2015	European Journal of Pharmaceutics and Biopharmaceutics2015，，89：	1
8	Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy显示文摘	Tackenberg B Jelcic I Baerenwaldt A	2009	Proc Natl Acad Sci USA2009，106，12：	1
9	Solid state of processed carbohydrate matrices from maltodextrin and sucrose显示文摘	Tackenberg M W Thommes M Schuchmann H P	2014	Journal of Food Engineering2014，，129：	1
10	Back or neck - pain - related disability of nursing staff in hospitals, nursing homes and home care in seven countries:results from the European NEXT - Study 显示文摘	Simon M Tackenberg P Nienhaus A	2008	Int J Nurs Studies2008，19，45：	1
11	Modeling long-distance dispersal of plant dias- poras by wind 显示文摘	Tackenberg O 2003	2003	Ecological Monographs2003，73，2：	1
12	Clonalexpansions of CD4+ B helper T cells in autoimmune myastheniagravis显示文摘	Tackenberg B Kruth J Johanna E B	2007	Eur J Immunol2007，37，3：	1
13	Dendelion seed dis- persal: the horizontal wind dispersal does not matter for long-dis- tance dispersal-it is updraft! 显示文摘	Tackenberg O Poschlod P Kahmen S 2003	2003	Plant Biology2003，5，：	1
14	CNS involvement in hereditary neuropathy with pressure palsies (HNPP)显示文摘	Tackenberg B Moller JC Rindock H etal	2006	Neurology2006，67，12：	1
15	Effort-reward imbalance among nurses in stable countries and in countries intransition显示文摘	HASSEL HORN H M TACKENBERG P PETER R	2004	Int J Occup Environ Health2004，10，4：	1
16	Effort- reward imbalance among nurses in stable count ties and in count ries in t ransition显示文摘	HASSEL HORN H M TACKENBERG P PETER R	2004	Int J Occup Environ Health2004，10，4：	1
17	Effort-reward imbalance among nurses in stable countries and in countries in transition显示文摘	HASSELHORN H M TACKENBERG P PETER R	2004	Int J Occup Environ Health2004，10，4：	1
18	Back or neck-pain-related disability of nursing staff in hospitals,nursing homes and homecare in seven countries-results from the? European NEXT-Study显示文摘	Simon M Tackenberg P Nienhaus A	2008	Internation- al Journal of Nursing Studies2008，，45：	1
19	CNS involvement in hereditary neuropathy with pressure palsies(HNPP) 显示文摘	Tackenberg B Moiler JC Rindock H	2006	Neurology2006，67，12：	1
20	Immuno- suppressive treatment of ocular myasthenia gravis 显示文摘	Tackenberg B Hemmer B Oertl WH	2001	Bio Drugs2001，15，6：	1

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