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| 1 | Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties显示文摘This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond,two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V.negundo. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex species.The compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed. | Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan | 2018 | Journal of Integrative Medicine2018，16，3： | 6 |
| 2 | Diabetic muscle infarction in end-stage renal disease: A scoping review on epidemiology, diagnosis and treatment显示文摘Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease(ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (Pub Med/MEDLINE, CINAHL, SCOPUS and and EMBASE) searches were conducted for ('diabetic muscle infarction' or 'diabetic myonecrosis') and('chronic kidney disease' or 'renal impairment' or 'dialysis' or 'renal replacement therapy' or 'kidney transplant ') from January 1980 to June 2017. Relevant cases from reviewed bibliographies in reports retrieved were also included. Data were extracted in a standardized form. A total of 24 publications with 41 patients who have ESRD were included. The mean age at the time of presentation with DMI was 44.2 years. Type 2 diabetes was present in 53.7% of patients while type 1 in 41.5%. In this cohort, 60.1% were receiving hemodialysis, 21% on peritoneal dialysis and 12.2% had kidney transplantation. The proximal lower limb musculature was the most commonly affected site. Muscle pain and swelling were the most frequent manifestation on presentation. Magnetic resonance imaging (MRI) provided the most specific findings for DMI. Laboratory investigation findings are usually non-specific. Non-surgical therapy is usually used in the management of DMI. Short-term prognosis of DMI is good but recurrence occurred in 43.9%. DMI is an uncommon complication in patients with diabetes mellitus, including those affected by ESRD. In comparison with unselected patients with DMI, the characteristics and outcomes of those with ESRD are generally similar. DMI may also occur inkidney transplant recipients, including pancreas-kidney transplantation. MRI is the most useful diagnostic investigation. Non-surgical treatment involving analgesia, optimization of glycemic control and initial bed rest can help to improve recovery rate. However, recurrence of DMI is relatively frequent. | Tuck Yean Yong Kareeann Sok Fun Khow | 2018 | World Journal of Nephrology2018，7，2： | 4 |
| 3 | Phenolic constituents from the root bark of Morus alba with emphasis on morusin and its anti-cancer properties显示文摘The root bark of Morus alba L. or white mulberry is widely used as traditional medicine in China, Japan and Korea. Major classes and types of phenolic compounds isolated from the root bark are flavonoids(kuwanons, morusin, cyclomorusin and sanggenons), benzofurans(moracins and mulberrofurans), and stilbenoids(mulberrosides). Some of the flavonoids and benzofurans are products of Diel-Alder type adducts. Other classes of compounds include triterpenes, phenolic acids and coumarins. Morusin, a prenylated flavonoid, was first isolated from the root bark of M. alba, and later from the leaf, stem bark and twig of the plant. The potent anti-cancer properties of morusin have attracted much attention with research on-going and new findings being published. The compound inhibits angiogenesis, tumour progression and tumour migration, and triggers apoptosis, cell cycle arrest and autophagy in colorectal, cervical, prostate, breast, hepatoma, pancreatic, glioblastoma, gastric, ovarian and lung cancer cell lines. The anti-cancer activities of morusin are executed via various molecular targets and signalling pathways. It is anticipated that on-going in vitro studies will progress gradually to in vivo studies using animal models before efforts towards drug development can be initiated for clinical trials. | Eric Wei Chiang Chan Siu Kuin Wong Tomomi Inoue Hung Tuck Chan | 2019 | Journal of Chinese Pharmaceutical Sciences2019，28，2： | 3 |
| 4 | Alpinia zerumbet, a ginger plant with a multitude of medicinal properties: An update on its research findings显示文摘In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herbal teas. Rhizomes are consumed as spices, and stem fibers are made into paper, fabrics, and handicrafts. In Brazil, tea from A. zerumbet leaves is believed to have hypotensive, diuretic, and anti-ulcerogenic properties. This species possesses many medicinal properties due to its chemical constituents, including flavonoids, phenolic acids, phenylpropanoids, kava pyrones, sterols, and terpenoids. Extracts of A. zerumbet display antioxidant, antimicrobial, insecticidal, anthelmintic, tyrosinase and melanogenesis inhibitory, anti-atherogenic, anti-aging, anti-glycation, integrase and neuraminidase inhibitory, lifespan prolongation, hair growth promotion, anticancer, antidepressant, anxiolytic, anti-obesity, analgesic, anti-inflammatory, hypolipidemic, anti-ulcerogenic, anti-platelet, osteoblastic, osteogenic, thrombolytic, and cardiac arrhythmogenic activities. Essential oils of A. zerumbet leaves have antimicrobial, larvicidal, antinociceptive, hypotensive, vasorelaxant, myorelaxant, antispasmodic, antidepressant, anxiolytic, anti-neuraminidase, anti-atherogenic, anti-aging, anti-melanogenic, anti-tyrosinase, cytoprotective, cardiodepressive, antipsychotic, analgesic, anti-inflammatory, and tissue healing activities. Clinical trials conducted in Brazil showed that extracts of A. zerumbet have hypotensive and diuretic effects whereas topical application of the essential oil has positive therapeutic effects on patients with fibromyalgia. Spanning two continents of Asia and South America, A. zerumbet is truly a multi-purpose ginger plant with promising medicinal properties. | Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，11： | 2 |
| 5 | A systematic review and meta-analysis of gastric cancer treatment in patients with positive peritoneal cytology显示文摘 | Carlos Suhady Cabalag Steven Tuck Foo Chan Yui Kaneko Cuong Phu Duong | 2015 | Gastric Cancer2015，，1： | 2 |
| 6 | Social neurological and cognitive disorders in alcoholics显示文摘 | Tuck RR Jackson M | 1991 | Med J Aust1991，155，： | 2 |
| 7 | Osteopontin overexpression in breast cancer:knowledge gained and possible implications for clinical management显示文摘 | TUCK AB CHAMBERS AF ALLAN AL | 2007 | J Cell Biochem2007，102，4： | 1 |
| 8 | CAVA: Hiding L2 Misses with Checkpoint Assisted Value Prediction显示文摘 | Ceze L Strauss K Tuck J | 2004 | Computer Architecture Letters2004，，： | 1 |
| 9 | The Effect of Aldosterone on Glucose Metablism显示文摘 | Corry DB Tuck ML | 2003 | Curr Hypertens Rep2003，5，2： | 1 |
| 10 | Osteopontin over expression in breast cancer:knowledge gained and possible implications for clinical management显示文摘 | Tuck AB Chambers AF Allan AL | 2007 | J Cell Biochem2007，102，4： | 1 |
| 11 | Apo(a)-isoform size,nutritional status and inflammatory markers in chronic renal failure显示文摘 | Stenvinkel P Heimburger O Tuck CH | 1998 | Kidney Int1998，53，5： | 1 |
| 12 | The effect of aldosterone on glucose metabolism显示文摘 | Corry DB Tuck ML | 2003 | Current Hypertension Reports2003，5，2： | 1 |
| 13 | Ship motions and sea loads 显示文摘 | Salvesen N Tuck E O Faltisnsen O | 1970 | Trans SNAME1970，78，： | 1 |
| 14 | The role of osteopontin in breast cancer: clinical and experimental studies 显示文摘 | Tuck AB Chambers AF | 2001 | Mammary Gland Biol Neoplasia2001，6，4： | 1 |
| 15 | Epidermal Keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatorv dermatoses显示文摘 | Tuck DT Sampson HA | 1989 | J Invest Dermatol1989，92，5： | 1 |
| 16 | Serial plasma osteopon-tin levels have prognostic value in metastatic breast cancer显示文摘 | Bramwell VH Doig GS Tuck AB | 2006 | Clin Cancer Res2006，12，11： | 1 |
| 17 | 1311-tositumomab therapy as initial treatment for follicular lymphoma显示文摘 | Kaminski MS Tuck M Estes J | 2005 | N Engl J Med2005，352，5： | 1 |
| 18 | Osteopontin - induced mi- gration of human mammary epithelial cells involves activa - tion of EGF receptor and multiple signal transduction pathways 显示文摘 | Tuck A B Hota c Wilson S M | 2006 | On- cogene2006，22，8： | 1 |
| 19 | Obesity associated hypertension, hypothesized link between etiology and selection of therapy 显示文摘 | Reisin E Tuck ML | 1999 | Blood Press Monit1999，，： | 1 |
| 20 | Characterization of the human p53 gene promoter显示文摘 | CRAWFORD L | 1989 | Mol Cell Biol1989，9，5： | 1 |
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