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| 1 | NKX6-1是胰腺及十二指肠神经内分泌肿瘤新的免疫组化标志物显示文摘Tseng I C, Yeh MM, YangCY, etal. NKX6-1 isanovelim- munohistochemical marker for pancreatic and duodenal neuroen- docrine tumors. Am J Surg Pathol, 2015,39(6) :850 -7.胃肠道神经内分泌肿瘤分为高分化神经内分泌肿瘤(WDNETs)及低分化神经内分泌癌(PDNECs),前者通常进行手术切除和(或)分子靶向治疗,而PDNECs通常采用化疗。NKX6-1是一种同源框转录因子,参与胰岛内分泌功能的发生和调节。 | Tseng I C Yeh M M Yang C Y 胡舜 余英豪 | 2015 | 临床与实验病理学杂志2015，31，8： | 5 |
| 2 | Dopaminergic effects on in vitro osteogenesis显示文摘Multiple growth factors(e.g., BMP2, TGF-b1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine(PDA) and dopamine(DA) monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA's role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression(ALP, BSP, OC, OSX, RUNX2, and Collagen1a2) with or without receptor antagonists(SCH233390 and GR103691). Two-way ANOVA was used for statistical analysis. All five DA receptors(D1, D2, D3, D4, and D5) m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days(P, 0.05). Osteogenic mineralization was significantly greater in the DA-treated group than control group(P, 0.05). Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair. | Dong Joon Lee Henry C Tseng Sing Wai Wong Zhengyan Wang Meng Deng Ching-Chang Ko | 2015 | Bone Research2015，3，3： | 3 |
| 3 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 4 | Degradation of 2 - chlorophenol via a hydrogenotrophic biofihn under different reductive conditions显示文摘 | CHANG C C TSENG S K CHANG C C | 2004 | Chemosphere2004，56，： | 1 |
| 5 | Effect of phosphorus dopant on photoluminescence and field-emission characteristics of MgZnO nanowires显示文摘 | Lee C Y Tseng T Y Li S Y | 2006 | J Appl Phys2006，99，24： | 1 |
| 6 | Effect of Ozone and Permanganate on Algae Coagulation Removal-Pilot and Bench Scale Tests 显示文摘 | Chen J J Yeh H H Tseng C | 2009 | Chemosphere2009，74，6： | 1 |
| 7 | Production of polysaccharides from Ganoderma lucidum (CCRC 36041) under limitations of nutrients 显示文摘 | HSIEH C TSENG M H LIU C J | 2006 | Enzyme Microbial Technol2006，38，12： | 1 |
| 8 | Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients显示文摘 | TSENG P L TAI M H HUANG C C | 2008 | J Surg Oncol2008，98，5： | 1 |
| 9 | A scrambling method for fingerprint positioning based on temporal diversity and spatial dependency 显示文摘 | Kuo S P Tseng Y C | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，5： | 1 |
| 10 | Eigenfilter approach for the design of variable fractional delay FIR and all-pass filters显示文摘 | Tseng C C | 2002 | IEEE Proc Vis Image Signal Process2002，149，5： | 1 |
| 11 | Study in IC Chip Failure during Pick-up Process by Using Experimental and Finite Element Methods 显示文摘 | T H Cheng C C Du C H Tseng | 2006 | Journal of Materials Processing Technology2006，172，： | 1 |
| 12 | Method for large-scale isolation and purification of R-phycoerythrin from red alga Polysiphonia urceolata Grev显示文摘 | NIU J F WANG G C TSENG C K | 2006 | Protein Expression and Purification2006，49，： | 1 |
| 13 | H∞ decentralized fuzzy model reference tracking control design for nonlinear interconnected systems显示文摘 | Tseng C S Chen B S | 2001 | IEEE Transactions on Fuzzy Systems2001，9，6： | 1 |
| 14 | Modeling of the wear mechanism during chemical mechanical polishing of tungsten显示文摘 | LIU C DAI B Tseng W | 1996 | Wear of the Electrochemical Society1996，143，2： | 1 |
| 15 | Fuzzy Tracking Control Design for Nonlinear Dynamic Systems via T - S fuzzy Model 显示文摘 | Tseng C S Chen B S Uang H | 2001 | IEEE Transactions on Fuzzy Systems2001，9，3： | 1 |
| 16 | Experimental antitumor agents from Solanum indicum L 显示文摘 | Chiang H C Tseng T H Wang C J | 1991 | Anticancer Res1991，11，5： | 1 |
| 17 | low-dose intraoperative mitomycin cas chemoadjuvent for pteryium surgery 显示文摘 | Cheng H C Tseng S H Kao P L | 2001 | Cornea2001，20，1： | 1 |
| 18 | Wettability and superhydrophilic TiO2 film formed by chemical vaopor deposition显示文摘 | Kuo C S Tseng Y H Li Y Y | 2006 | Chemistry Letters2006，，4： | 1 |
| 19 | Quadratic-interval bass model for new product sales diffusion显示文摘 | Tseng F M Hu Y C | 2009 | Expert Systems with Applications2009，36，： | 1 |
| 20 | Diabetes and risk of esopha geal and gastric adenocarcinomas 显示文摘 | Jiang X J Bernstein L Tseng C C | 2012 | Int J Cancer2012，131，6： | 1 |
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