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| 1 | Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells显示文摘在现在的学习,我们在 Jurkat T 白血病房间调查了在 proteasome 禁止者 carfilzomib (CFZ ) 和 histone deacetylaseinhibitor vorinostat 之间的相互作用。到 CFZ 与的最低限度地致命的集中的细胞的 Coexposure 很, vorinostat 的 lowconcentration 导致了 synergistic antiproliferative 效果并且在 Jurkat T-leukemiacells 提高了 apoptosis ,与严厉地增加的反应的氧种( ROS )伴随了,在 mitochondrial membranepotential ( MMP )的惹人注目的减少,细胞色素 c 的增加的版本, caspase-9 和-3,和 PARP.The 的劈开的提高的激活联合了 Jurkat 细胞的处理与 ROS 预先对待而且, NAC 也在 apoptotic 房间导致了显著减小,显示为由联合处理的 increasedROS 产生的一个关键角色。另外,联合了逮捕的处理在 G 2-M 的房间周期阶段。这些结果暗示 CFZ 在 Jurkat T 白血病房间与 vorinostat synergistically 交往了,哪个有 vorinostat 的 carfilzomib 的联合可以在对待 T 房间代表新奇策略的 raisedthe 可能性白血病。 | Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 2 | Probiotic Medilac-S^(█) for the induction of clinical remission in a Chinese population with ulcerative colitis: A systematic review and meta-analysis显示文摘AIM To assess the effects of probiotic Medilac-S~ as adjunctive therapy for the induction of remission of ulcerative colitis(UC) in a Chinese population through a systematic review and meta-analysis. METHODS A systematic literature search was conducted to find randomized, controlled trials in a Chinese population with at least two study arms-a control arm which receives a conventional, oral aminosalicylate drug, and a treatment arm, which administers the same conventional drug in conjunction with the probiotic Medilac-S~ per os. Both English and Chinese databases were searched, including Pub Med, EMBASE, Google Scholar, Chinese National Knowledge Infrastructure, Wanfang Data, and VIP Search, and study data was extracted onto standardized abstraction sheets. Meta-analyses were conducted for primary and secondary outcomes of interest using a fixed or random effects model. The primary outcome was the induction of clinical remission and the secondary outcomes included changes in Sutherland index, endoscopic and histological scores, proportion of reported clinical symptoms and adverse events(AEs). For outcomes with sufficient data, the type of conventional drug therapy was also assessed to determine if the effects of combination therapy with Medilac-S~ was influenced by drug type. All tests were conducted using a type Ⅰ error rate of 0.05 and all confidence intervals(CI) were based on a 95% confidence level. Review protocol was uploaded to PROSPERO(CRD42018085658 upon completion).RESULTS Fifty-three clinical trials with a total of 3984 participants were identified and included in the review. Medilac-S~ adjunctive therapy significantly improved induction of clinical remission(RR = 1.21; 95%CI: 1.18-1.24; P < 0.0001) with the estimated likelihood of effective treatment, on average, 21% higher for those consuming the probiotic. Sutherland index scores showed the control mean was on average 3.10(CI: 2.41-3.78; P = 0.0428) units greater than the treatment mean, thereby demonstrating significant improvement in participants taking the probiotic. Similarly, a significant difference was seen between the overall reduction of endoscopic and histological scores of control and treatment arm participants, with score decreases in the control groups 0.71(CI: 0.3537-1.0742) and 1.1(CI: 0.9189-1.2300) units smaller than treatment group score decreases. The proportion of participants reporting clinical symptoms,(abdominal pain, tenesmus, blood and mucous in stool, and diarrhea) was significantly reduced after combination therapy with Medilac-S~(P < 0.0001) and estimated to be on average 44%(RR = 0.44, CI: 0.32-0.59), 53%(RR = 0.53, CI: 0.38-74), 40%(RR = 0.40, CI: 0.28-0.58) and 47%(RR = 0.47 CI: 0.36-0.42) respectively, of the proportion of individuals reporting the aforementioned symptoms after conventional therapy alone. The risk of AEs was also significantly reduced with adjunctive Medilac-S~ therapy. The proportion of individuals in the treatment groups reporting AEs was an estimated 72% of the proportion of individuals in the control groups reporting AEs(RR = 0.72, CI: 0.55-0.94, P = 0.0175). Upon comparing effect means for different drug types in conjunction with Medilac-S~, evidence of significant variability(P < 0.0001) was observed, and sulfasalazine was found to be the most effective drug in both primary and secondary outcomes. CONCLUSION Evidence suggests Medilac-S~ adjunctive therapy should be considered standard care for UC in a Chinese population because it aids in the induction of clinical remission, improves symptoms of the gastrointestinal tract and reduces risk of AEs. | Ghania Sohail Xiaoyu Xu Mary C Christman Thomas A Tompkins | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 3 | 鸽舍显示文摘项目名称:Dovecote Studio项目设计:Haworth Tompkins项目地点:英国,Suffolk,Snape业主:Aldeburgh Music摄影:Philip Vile在伦敦东北部100公里处,有一个小镇,名叫奥尔德堡。是作曲家本杰明·布里顿的家乡,更是他那著名的歌剧《彼得·格林》故事背景所在地。 | Frank Haworth Tompkins | 2011 | 建筑知识2011，31，2： | 2 |
| 4 | 显示文摘 | Zorn M E Tompkins D T Zeltner W A | 1999 | Appl Cata B1999，23，： | 2 |
| 5 | Artificial skin in massive burns-rcsults to ten years显示文摘 | Sheridan RL Hegarty M Tompkins RG | 1994 | Eur J Plast Surg1994，17，： | 1 |
| 6 | OF cats,humans,and bartonella显示文摘 | Tompkins LS | 1997 | N Eng1 J Med1997，337，24： | 1 |
| 7 | Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigra neurons显示文摘 | Tompkins MM Basgall A Offen D | 1997 | Am J Pathol1997，150，1： | 1 |
| 8 | Support of the metabolic response to burn injury 显示文摘 | Hemdon DN Tompkins RG | 2004 | Lancet2004，363，9424： | 1 |
| 9 | Titanium nitride oxidation chemistry: An X-ray photoelectron spectroscopy study 显示文摘 | Saha N C Tompkins H G | 1992 | Journal of Applied Physics1992，72，7： | 1 |
| 10 | Variability of EGRET Gamma-ray sources 显示文摘 | Nolan P L Tompkins W F Grenier I A | 2003 | Astrophys J2003，597，1： | 1 |
| 11 | Interactions between government and in- dustry food safety activities 显示文摘 | Tompkin R B | 2001 | Food Control2001，12，： | 1 |
| 12 | Anderson Photoeatalytic oxidation of acetone vapor on TiO2/ZrO2 thin films显示文摘 | Zorn Michael E Tompkins Dean T Zeltner Walter A | 1999 | Applied Cat ''dysis B: Environmental1999，23，1： | 1 |
| 13 | Oxygen uptake rates in cultured hepatocytes显示文摘 | Rotem A Toner M Tompkins RG | 1992 | Biotechnol Bioeng1992，40，： | 1 |
| 14 | Characteristics of application software maintenance显示文摘 | LIENTZ B P SWANSON E B TOMPKINS G E | 1978 | Communications of the ACM1978，21，6： | 1 |
| 15 | Spatial aggrega tion and temporal migration of free-living stages of the parasitic nematode Trichostrongylus tenuis 显示文摘 | Saunders L M Tompkins D M Hudson P J | 2000 | Functional Ecology2000，14，： | 1 |
| 16 | of cats,humans,and bartonella显示文摘 | Tompkins L S | 1997 | N Engl J Med1997，337，： | 1 |
| 17 | Identification in the self-managing organization: Characteristics of target and tenure显示文摘 | Barker J R Tompkins P K | 1994 | Human Communication Research1994，21，： | 1 |
| 18 | Volunteerism and special event management: A case study of Whistler' s Men' s World Cup of Skiing 显示文摘 | Williams P W Dossa K A Tompkins L | 1996 | Festival Management & Event Tourism1996，3，2： | 1 |
| 19 | Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon6a,b,c region, have specific effects on tooth germ development in culture 显示文摘 | Tompkins K Veis A | 2002 | Connect Tissue Res2002，43，23： | 1 |
| 20 | Titanium nitride oxidation chemistry:An x-ray photoelectron spectroscopy study 显示文摘 | SAHA N C TOMPKINS H G | 1992 | J Apply Phys1992，72，： | 1 |
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