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| 1 | 胶质瘤的基因治疗(英文)显示文摘Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy.Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths.To date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials.The most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal models.In this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM. | Tobias A Ahmed A Moon KS Lesniak MS. | 2013 | 中华神经外科疾病研究杂志2013，12，4： | 16 |
| 2 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 3 | Current medical management of endocrine-related male infertility显示文摘男因素贡献全面不孕的 50%-60% ,但是是完全负责的在仅仅 20% 夫妇。尽管很男的因素不孕从反常精液分析被查明,如果样品归还正常,另外的男因素能特别是贡献的。男不孕能由于可能可逆或不可逆的可看作是相同的神经质或解剖的病原学。这张手稿将包括多种维生素,雌激素受体调节的人(clomiphene ) ,雌激素变换 blockers (anastrozole ) ,和荷尔蒙代替为男不孕和实验治疗为荷尔蒙评估加亮存在指南和我们的建议。 | Joshua D Ring Aye A Lwin Tobias S Kohler | 2016 | Asian Journal of Andrology2016，18，3： | 12 |
| 4 | Patients with chronic obstructive pulmonary disease are at increased risk of death associated with urban particle air pollution: a case-crossover analysis 显示文摘 | Sunyer J Schwartz J Tobias A | 2000 | Am J Epidemiol2000，151，： | 2 |
| 5 | CD14,a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein显示文摘 | Wright S D Ramos R A Tobias P S | 1990 | Science1990，249，4975： | 2 |
| 6 | Dexmedetomidine: applications for the pediatric patient with congenital heart disease 显示文摘 | TOBIAS J D GUPTA P NAGUIB A | 2011 | PediatrCardiol2011，32，8： | 1 |
| 7 | Inactivation of human kidney cells by high-energy monoenergetic heavy-ion beams 显示文摘 | Blakely E A Tobias C A Yang T C H | 1979 | Radiation Research1979，80，1： | 1 |
| 8 | Probability hypothesis density-based multitarget tracking with bistatic range and doppler observations显示文摘 | Tobias M and Lanterman A D | 2005 | IET Radar Sonar and Navigation2005，152，3： | 1 |
| 9 | The APN's guide to ped- iatric constipation management显示文摘 | Mason D Tobias N Lutkenhoff M et a l | 2004 | The Nurse Practitioner2004，29，7： | 1 |
| 10 | The chatter of lathe tools under other cutting conditions显示文摘 | Tobias S A Fishwick W | 1958 | Transactions of the ASME1958，80，： | 1 |
| 11 | Procalcitonin and interleukin 6 for predicting blood culture positivity in sepsis显示文摘 | Naffaa M Makhoul BF Tobia A | 2014 | Am J Emerg Med2014，32，5： | 1 |
| 12 | Mechanisms of probiotic actions - A review显示文摘 | TOBIAS A OELSCHLAEGER | 2010 | International Journal of Medical Microbiology2010，，300： | 1 |
| 13 | The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wister rat显示文摘 | Tobia M H Zdanowicz M M Wingertzahn M A | 1998 | Mol Genet Metab1998，63，3： | 1 |
| 14 | Transmission of ActinobaciLlus pleuropneumoniae among weaned piglets on endemically infected farms显示文摘 | Tobias T J Bouma A Van Den Broek J | 2014 | Prev Vet Med2014，117，1： | 1 |
| 15 | Theory of regenerative machine tool chatter显示文摘 | Tobias S A Fishwick W | 1958 | The Engineer1958，205，： | 1 |
| 16 | Current status of silicon carbide based high-temperature gas sensors 显示文摘 | Spetz A L Tobias P Baranzahi A | 1999 | IEEE Trans Elec Dev1999，46，3： | 1 |
| 17 | Patients with chronic obstructive pulmonary disease are at increased risk of death associa- ted with urban particle air poUution:a case-crossover analysis显示文摘 | Sunyer J Schwartz J Tobias A | 2000 | Am J Epidemiol2000，151，： | 1 |
| 18 | Assessing the influence of a single study in the meta-analysis estimate显示文摘 | Tobias A | 1999 | Stata Tech Bull1999，8，47： | 1 |
| 19 | Theory of Regenerative Machine Tool Chatter显示文摘 | Tobias S A Fishwick W | 1958 | Engineering London1958，，205： | 1 |
| 20 | Techniques for birth-particle placement in the probability hypothesis density particle filter applied to passive radar显示文摘 | Tobias M and Lanterman A D | 2008 | IET Radar Sonar and Navigation2008，2，5： | 1 |
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