|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 3 | NCI sponsored international working group 显示文摘 | Cheson BD Homing S J Coiffier B : Report of an internation- al workshop to standardized response criteria for non-Hodgkin' s lymphomas | 1999 | J Clin Oncol1999，17，4： | 1 |
| 4 | A common RNA motif in the 3'end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus显示文摘 | Jonassen CM Jonassen TO Grinde B | 1998 | J Gen Virol1998，79，4： | 1 |
| 5 | Unusual consequences of'in- complete' laparoscopic cholecystectomy 显示文摘 | Szijat'to A Levay B Kupcsulik P | 2014 | Eur J Gastroenterol Hepatol2014，26，3： | 1 |
| 6 | A clinical trial comparing primary angioplesty with tissue plasminogen activator for acute myocardial infarction显示文摘 | The global use d strategies to open occluded coronary arteries in acute coronary syndromes( GUSTO Ⅱ b) angioplasty substudy invetigators | 1997 | N Engl J Med1997，336，： | 1 |
| 7 | A microplasticity analysis of micro-cutting force variation in ultra-precision diamond turning 显示文摘 | LEE W B CHEUNG C F TO S | 2002 | Journal of Manufacturing Science and Engineering2002，124，： | 1 |
| 8 | Insights from the Randomized Aldactone E- valuation Study (RALES) 显示文摘 | Zannad F Alia F Dousset B et ah Limitation of excessive extracellular ma- trix turnover may contribute to survival benefit of spironolactone therapy in pa- tients with congestive heart failure | 2000 | Circulation2000，102，： | 1 |
| 9 | Intraarticular lesions in primary frozen shoulder after manipulation under general anesthesia显示文摘 | Loew M Heichel TO Lehner B | 2005 | J Shoulder Elbow Surg2005，14，1： | 1 |
| 10 | Use of EBSD to Study Stress Induced Microstructural Changes in Zn-Al Based Alloy显示文摘 | Zhu Y H Lee W B to S | 2003 | Materials Science and Engineering2003，348，： | 1 |
| 11 | A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction显示文摘 | The Global Use of Strategies to Open Occluded Coronary Ateries in Acute Coronary Syndromes GUSTO Ⅱb Angioplasty Substudy Investigators | 1997 | N Engl J Med1997，336，： | 1 |
| 12 | the hydrogenation of basis of a coke formation kinetics-investigations in an isothermal catalytic wall reactor显示文摘 | KLEMM E AMON B Deactivation kinetics in nitrobenzene to aniline on the REDLINGSHOFER H | 2001 | Chemical Engineering Science2001，56，4： | 1 |
| 13 | Survival of Brevibacterium linens (ATCC 9174) after spray drying, freeze drying, or freezing 显示文摘 | To B C S Etzel M | 1991 | Journal of Food Science1991，62，： | 1 |
| 14 | Numerical Simulation of Residual Stress and Birefringence in The Precision Injec- tion Molding of Plastic Microlens Arrays显示文摘 | Can Weng W B Lee S To | 2009 | International Communications in Heat and Mass Transfer2009，36，： | 1 |
| 15 | FKF1 conveys timing information for Constans stabilization in photoperiodic flowering显示文摘 | SONG Y H SMITH R W TO B J | 2012 | Science2012，336，6084： | 1 |
| 16 | Excision and transcutaneouslift in patients with neurofibromatosis of the fronto -temporo -orbital and auricular regions 显示文摘 | Acariturk TO Yigenoglu B Pekedis O | 2009 | J Craniofacial Surg2009，20，3： | 1 |
| 17 | Systematic review of antidepressants in the treatment of chronic low back pain 显示文摘 | Staiger TO Gaster B Sullivan MD | 2003 | Spine2003，28，： | 1 |
| 18 | Platelet aggregates- genitor cell proliferation and and foam cells is mediated by in vitro 显示文摘 | Stellos K Seizer P Bigalke induced human CD34 + pro different stromal Hemost iation to macrophages cell derived factor 1 B | 2010 | Semin Thromb2010，36，2： | 1 |
| 19 | Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma-a prospective study 显示文摘 | Ma B B Poon T C To K F | 2003 | Head Neck2003，25，10： | 1 |
| 20 | A Study of The Relevant Effects on The Maximum Residual Stress in The Precision Injec- tion Moulding of Microlens Arrays显示文摘 | C Weng W B Lee S To | 2010 | Journal of Micro- mechanics and Microengineering2010，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员